18期

最新文章

• LRBA organizes distinct vesicular trafficking systems in distal nephron segments for water and sodium conservation AI翻译
  作者：Nagaoka, Kanako; Ando, Fumiaki; Fujiki, Tamami; Abolhassani, Hassan; Hara, Yu; Yanagawa, Hideki; Suzuki, Soichiro; Sakamaki, Yuriko; Oikawa, Daisuke; Kikuchi, Hiroaki; Mandai, Shintaro; Mori, Yutaro; Mori, Takayasu; Susa, Koichiro; Sohara, Eisei; Hoshino, Akihiro; Ito, Tsuyoshi; Arakawa, Yuki; Sasahara, Yoji; Yasuda, Shinsuke; Abe, Yoichiro; Yasui, Masato; Tokunaga, Fuminori; Kanegane, Hirokazu; Uchida, Shinichi
  作者单位：Institute of Science Tokyo; Tehran University of Medical Sciences; University of Bonn; Institute of Science Tokyo; Osaka Metropolitan University; Institute of Science Tokyo; Saitama Children's Medical Center; Tohoku University; Institute of Science Tokyo; Keio University
  摘要：Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) deficiency is a rare genetic disorder characterized by immune dysregulation. The immune checkpoint molecule cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) fails to perform proper membrane trafficking in the absence of LRBA. In addition to immune cells, LRBA localizes to intracellular vesicles in various epithelial cells; however, its physiological roles have not been accurately deciphered. It was observed in this study th...
• Expanding the repertoire for molluscan structural colors AI翻译
  作者：Williams, Suzanne T.; Ingram, Abigail L.
  作者单位：Natural History Museum London
• Broad neutralization of influenza B hemagglutinin antibodies via receptor mimicry and glycan engagement AI翻译
  作者：Huang, Kuan-Ying A.; Nguyen, Hong Thuy Vy; Chen, Yi-Yin; Wu, Kai-Jung; Hsu, Po-Hsien; Liu, Yo-Min; Lin, Tzou-Yien; Ma, Che
  作者单位：National Taiwan University; National Taiwan University Hospital; National Taiwan University; National Taiwan University Hospital; Academia Sinica - Taiwan; National Defense Medical University; Chang Gung University; Chang Gung Memorial Hospital; Chang Gung University
  摘要：Influenza B virus contributes to seasonal influenza epidemics and causes global morbidity and mortality. The two antigenically distinct lineages, Victoria and Yamagata, cocirculate within the population and are subject to ongoing antigenic drift. In this study, we report the isolation of cross-lineage neutralizing anti-influenza B hemagglutinin (HA) monoclonal antibodies, exhibiting hemagglutination-inhibition activities, from vaccinated adult donors. While some antibodies exhibit reduced acti...
• Solution-state nanoconfined aggregation and microstructure evolution in blends of conjugated polymers and elastomers AI翻译
  作者：Pena-Alcantara, Amnahir E.; Ghasemi, Masoud; Cheng, Christina; Chaney, Thomas P.; Coffey, Aidan H.; Ponte, Elisa; Ji, XiaoZhou; Michalek, Lukas; Wu, Yilei; Schrock, Max; Ngaruka, Gradie; Gala, Michal L.; Zhu, Chenhui; Toney, Michael F.; Salleo, Alberto; Gomez, Enrique D.; Bao, Zhenan
  作者单位：Stanford University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Colorado System; University of Colorado Boulder; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Stanford University; Stanford University; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
  摘要：Emerging wearable health monitoring technologies require conformable and stretchable devices. Polymer semiconductors composed of pi-conjugated polymer aggregates in an elastomeric matrix are remarkable in their ability to provide both high stretchability and enhanced charge transport. Understanding their film formation process is critical in improving charge transport, imparting added functionalities, and advancing large-scale production of high-performing polymer electronic devices. Here, usi...
• Homologous specialization of arcuate fasciculus ventrolateral frontal connectivity in marmosets and humans AI翻译
  作者：Wang, Yufan; Cheng, Luqi; Li, Deying; Lu, Yuheng; Hopkins, William D.; Sherwood, Chet C.; Xu, Ting; Liu, Cirong; Paxinos, George; Jiang, Tianzi; Chu, Congying; Fan, Lingzhong
  作者单位：Chinese Academy of Sciences; Institute of Automation, CAS; Chinese Academy of Sciences; Institute of Automation, CAS; Nanjing Institute of Geology & Paleontology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Guilin University of Electronic Technology; Tsinghua University; Tsinghua University; University of Texas System; UTMD Anderson Cancer Center; George Washington University; George Washington University; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Neuroscience Research Australia; University of New South Wales Sydney; University of Health & Rehabilitation Sciences; Shandong Medical & Pharmaceutical University
  摘要：The arcuate fasciculus (af) is a crucial dorsal pathway underpinning human language, yet its weak frontal connectivity in macaques-the standard primate model-creates an evolutionary puzzle. Here, we investigate the common marmoset, a distantly related platyrrhine with high vocal complexity, to test for convergent neural adaptations. By integrating retrograde and anterograde tracing with ultra-high-resolution diffusion MRI, we identified a robust af homolog in marmosets that is anatomically dis...
• An Ad5-vectored platform generating self-assembling VLPs elicits potent mucosal immunity against influenza A virus and SARS-CoV-2 AI翻译
  作者：Zhang, Yuan; Wang, Caiqian; Zheng, Yanhong; Chen, Feiyu; Feng, Yaya; Fang, Lingying; Wang, Zongmei; Zhou, Ming; Fu, Zhen F.; Zhao, Ling
  作者单位：Huazhong Agricultural University; Huazhong Agricultural University; Huazhong Agricultural University; University System of Georgia; University of Georgia; Hubei Hongshan Laboratory; Hubei Jiangxia Laboratory
  摘要：Integrating complementary vaccine modalities is essential for combating emerging pathogens. Although the recent mRNA-VLP hybrids enable spontaneous virus-like particles (VLPs) self-assembly, thereby enhancing immunogenicity, they fail to elicit robust pulmonary mucosal immunity against respiratory pathogens. Here, we developed Ad5-Envp-VLP, a chimeric adenoviral platform enabling spontaneous in vivo assembly of envelope protein-displaying VLPs using advanced technology that recruits ESCRT (end...
• Deep mining of the human antibody repertoire identifies frequent and genetically diverse CDRH3 topologies targetable by vaccination AI翻译
  作者：Habib, Rumi; Solieva, Shahlo O.; Lin, Zi Jie; Ghosh, Sukanya; Bayruns, Kelly; Singh, Maya; Agostino, Colby J.; Tursi, Nicholas J.; Sowers, Kirsten J.; Huang, Jinwei; Roark, Ryan S.; Purwar, Mansi; Park, Younghoon; Ayyanathan, Kasirajan; Li, Hui; Carey, John W.; Kim, Amber; Park, Joyce; McCanna, Madison E.; Skelly, Ashwin N.; Chokkalingam, Neethu; Kriete, Sinja; Shupin, Nicholas; Huynh, Alana; Walker, Susanne; Sadeesh, Roopak; Laenger, Niklas; Du, Jianqiu; Cui, Jiayan; Patel, Ami; Escolano, Amelia; Kwong, Peter D.; Shapiro, Lawrence; Bowman, Gregory R.; Hahn, Beatrice H.; Shaw, George M.; Weiner, David B.; Pallesen, Jesper; Kulp, Daniel W.
  作者单位：The Wistar Institute; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; Indiana University System; Indiana University Bloomington; University of Pennsylvania; Pennsylvania Medicine; Saint Joseph's University; Columbia University; Columbia University; Columbia University
  摘要：Germline targeting vaccination strategies against highly variable pathogens such as HIV aim to elicit broadly neutralizing antibodies (bnAbs) with particular immunogenetic or structural features. The V2 apex of the HIV Env protein is a promising target for a class of bnAbs that contain conserved structural motifs in the heavy chain complementarity determining region 3 (CDRH3). Here, we show that these structural motifs are targetable by vaccination by characterizing V2 apex axe-like CDRH3s in ...
• Gingipain proteases from the bacterium Porphyromonas gingivalis confer protection against airway viral infection AI翻译
  作者：Rodriguez Hernandez, Carlos J.; Cruz-Cruz, Alonso; Shrestha, Chandra L.; Terekhova, Marina; Chen, Phylip; Perpich, John; Potempa, Barbara; Carey, Katherine; Rohlfing, Michelle; Peeples, Mark E.; Grayson, Mitchell H.; Potempa, Jan; Artyomov, Maxim; Lamont, Richard J.; Bagaitkar, Juhi
  作者单位：University System of Ohio; Ohio State University; Nationwide Childrens Hospital; Washington University (WUSTL); University of Louisville; University System of Ohio; Ohio State University; Nationwide Childrens Hospital; Research Institute at Nationwide Children's Hospital; Center for Clinical & Translational Research; University System of Ohio; Ohio State University; Nationwide Childrens Hospital; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University
  摘要：Physical interactions with bacterial colonizers at mucosal barrier surfaces can have beneficial or detrimental effects on viral infectivity and transmission. The oropharyngeal mucosal surface is a major portal of entry for many pathogenic respiratory viruses, such as respiratory syncytial virus (RSV), and also harbors a rich and diverse microbiome. Whether oropharyngeal bacteria directly or indirectly influence host susceptibility to respiratory viruses remains unknown. Here, we show that Porp...
• Computational design of an ultrapotent deltacoronavirus miniprotein inhibitor AI翻译
  作者：Avery, Nathan G.; Yoshiyama, Courtney N.; Taylor, Ashley L.; Park, Young-Jun; Asarnow, Daniel; Perruzza, Lisa; Brown, Jack T.; Corti, Davide; Benigni, Fabio; Starr, Tyler N.; Veesler, David
  作者单位：University of Washington; University of Washington Seattle; Utah System of Higher Education; University of Utah; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
  摘要：Multiple spillovers of porcine deltacoronavirus (PDCoV) into humans in Haiti highlight its zoonotic potential and the need for targeted interventions. No approved vaccines or therapeutics are available for use in humans against any DCoVs. Here, we report the de novo design of PDCoV miniprotein inhibitors (aka minibinders, MBs) and show that one of them, MB11, binds with picomolar affinity to the PDCoV receptor-binding domain (RBD). MB11 potently inhibits PDCoV, outcompeting monoclonal antibodi...
• DARPins as pan-reactivators of temperature-sensitive p53 cancer mutants AI翻译
  作者：Munick, Philipp; Balourdas, Dimitrios-Ilias; Funk, Julianne S.; Yuksel, Busra; Mavridi, Danai; Heftel, Justin; Dreier, Birgit; Schaefer, Jonas V.; Schafer, Birgit; Knapp, Stefan; Telatar, Tumay; Akgul, Baki; Pluckthun, Andreas; Stiewe, Thorsten; Joerger, Andreas C.; Dotsch, Volker
  作者单位：Goethe University Frankfurt; Goethe University Frankfurt; Goethe University Frankfurt; Goethe University Frankfurt; Justus Liebig University Giessen; Philipps University Marburg; University of Zurich; University of Cologne; University of Cologne; Philipps University Marburg; Justus Liebig University Giessen
  摘要：The tumor suppressor p53 is the most frequently mutated protein in tumors and a target for drug development. More than 2000 cancer-associated p53 missense mutations have been reported, most of them located in the DNA-binding domain (DBD). Due to the low intrinsic thermostability of the latter, they often lead to unfolding at physiological temperature. Stabilizing the DBD with small molecules has been shown to be effective in reactivating the cavity-creating cancer mutant Y220C. Unfortunately, ...