18期

最新文章

• Mitochondrial double-stranded RNA fuels pancreatic cancer growth via RIG-I/TLR3 inflammation AI翻译
  作者：Milcarek, Andrew T.; Yeon, Minjeong; Esposito, Camilla; Kulkarni, Prerna; Kossenkov, Andrew V.; Madzo, Jozef; Faustino, Anneliese M.; Tang, Hsin-Yao; Storaci, Alessandra M.; Palleschi, Alessandro; Locatelli, Marco; Vaira, Valentina; Iacocca, Mary V.; Ward, Andrea; Sabesan, Arvind; Petrelli, Nicholas J.; Perego, Michela; Altieri, Dario C.
  作者单位：The Wistar Institute; University of Naples Federico II; The Wistar Institute; The Wistar Institute; The Wistar Institute; University of Milan; Helen F. Graham Cancer Center & Research Institute; Helen F. Graham Cancer Center & Research Institute; Helen F. Graham Cancer Center & Research Institute; Chungbuk National University
  摘要：Mitochondria activate inflammation and innate immunity to protect against infections, but the role in cancer is unknown. Here, we report that patients with pancreatic ductal adenocarcinoma (PDAC) with reduced levels of the mitochondrial scaffold, Mic60, or inner mitochondrial membrane protein, exhibit increased inflammation, high NF kappa B activity and production of TNF alpha. This is mediated by double-stranded RNA (dsRNA) released from structurally defective, Mic60-low mitochondria, which e...
• Computational design of HLA class I superbinders for broad T cell immunogenicity AI翻译
  作者：Peer, Elinor; Cohen-Lavi, Liel; Sette, Alessandro; Sidney, John; Hertz, Tomer
  作者单位：Ben-Gurion University of the Negev; Ben-Gurion University of the Negev; La Jolla Institute for Immunology; Fred Hutchinson Cancer Center
  摘要：Human leukocyte antigen (HLA) class I molecules are highly polymorphic, restricting peptide binding to narrow sequence subsets. Designing peptides that bind multiple HLA supertypes-termed superbinders-offers a promising strategy for broad-spectrum T cell vaccines and immunotherapies. Here, we present superHLA, a computational framework that combines Markov Chain Monte Carlo optimization with state-of-the-art major histocompatibility complex binding predictors to design synthetic 9-mer peptides...
• Circadian-informed modeling predicts regional variation in obesity and stroke outcomes under different permanent US time policies (vol 122, e2508293122, 2025) AI翻译
  作者：Weed, Lara; Zeitzer, Jamie M.
• 撤稿声明: A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance AI翻译
  作者：[Anonymous]
• Deforestation-focused policies do not reduce degradation in the Brazilian Amazon AI翻译
  作者：Cammelli, Federico; Gibbs, Holly K.; Gollnow, Florian; Levy, Samuel A.; Stigler, Matthieu; Garrett, Rachael D.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Cambridge; University of Cambridge; University of Wisconsin System; University of Wisconsin Madison; Stockholm Environment Institute; University of Geneva
  摘要：Forest degradation causes large declines in carbon stocks, biodiversity, and ecosystem services, despite leaving some trees standing. Over the past two decades, numerous conservation policies to halt deforestation have been rolled out, but relatively little attention has been paid to tackling degradation. More information is needed to understand how deforestation and degradation are linked and how ongoing efforts to reduce deforestation are impacting degradation. With a focus on the case of th...
• Mitochondrial fusion heterogeneity drives bidirectional tumor phenotypic transition in combined hepatocellular-cholangiocarcinoma AI翻译
  作者：Chen, Lin; Wang, Dalin; Qin, Weidong; Wang, Gang; Wu, Dan; Li, Jiaying; Wang, Xingchen; Wang, Yinping; Sun, Xiacheng; Zhao, Jing; Guo, Shanshan; Ji, Lele; Tian, Jiming; Ding, Rui; Nie, Yongzhan; Xing, Jinliang; Huang, Qichao
  作者单位：Air Force Medical University; Air Force Medical University; Dezhou University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University; Air Force Medical University
  摘要：Dysregulation of mitochondrial dynamics modulates malignant cell fate; however, the substantial heterogeneity in mitochondrial dynamics among tumor cells within individual tumor nodules and the resultant functional consequences remain inadequately characterized. In this study, we induced mosaic impairment of mitochondrial fusion in mouse liver under tumorigenic conditions and unexpectedly identified the formation of combined hepatocellular-cholangiocarcinoma (cHC), a monoclonal tumor displayin...
• The evolution of trust under institutional moral hazard AI翻译
  作者：Chiba-Okabe, Hiroaki; Plotkin, Joshua B.
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
  摘要：We study the behavior of an institution that broadcasts reputational signals to facilitate trust in a population. Using an online marketplace as a motivating example, we develop a theoretical model in which buyers and sellers are matched on a platform to engage in transactions involving moral hazard: After receiving payment, sellers may either faithfully deliver goods or renege. Although buyers do not observe a seller's true strategy-good-faith or bad-faith-the platform broadcasts binary reput...
• A causal role for the posterior corpus callosum in bimanual coordination AI翻译
  作者：Kang, Jung Uk; Snyder, Lawrence H.; Mooshagian, Eric
  作者单位：Washington University (WUSTL); University of California System; University of California San Diego; University of Texas System; UTMD Anderson Cancer Center
  摘要：Interareal communication is crucial for coordinated brain function. Given the largely contralateral organization of the brain, bimanual coordination likely depends on interactions across the two cerebral hemispheres for motor planning and execution. The parietal reach region (PRR) is an early node in the sensorimotor transformation stream. Here, we examined the contributions of direct callosal connections between left and right PRR to bimanual coordination. Using manganese-enhanced MRI, we tra...
• Fra-2 controls the response to the KRAS inhibitor MRTX-1133 in pancreatic ductal adenocarcinoma AI翻译
  作者：Testa, Erika; Dezi, Clara; Lovat, Francesca; Piro, Geny; Carbone, Carmine; Capece, Marina; Nigita, Giovanni; Putro, Erisa; Renzi, Elisabetta Di; Simeone, Alessandra; Bonetti, Luca Reggiani; Cirombella, Roberto; Magistri, Paolo; Corbo, Vincenzo; Pasini, Davide; Belletti, Barbara; Baldassarre, Gustavo; Vecchione, Andrea; Croce, Carlo M.; Rampioni Vinciguerra, Gian Luca
  作者单位：Sapienza University Rome; University System of Ohio; Ohio State University; University System of Ohio; James Cancer Hospital & Solove Research Institute; Ohio State University; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Universita di Modena e Reggio Emilia; Universita di Modena e Reggio Emilia; University of Verona; IRCCS Aviano (CRO)
  摘要：KRAS mutations are a hallmark of pancreatic ductal adenocarcinoma (PDAC), driving tumor initiation and progression in the vast majority of cases, with KRASG12D being the most prevalent variant. Recent advances have led to the development of mutation-specific KRAS inhibitors (KRASi), yet their clinical impact is hindered by the rapid onset of drug resistance. In this study, we identify Fos-related antigen-2 (Fra-2), a stress-responsive transcription factor of the AP-1 family, as a key mediator ...
• Thermal SU(2) lattice gauge theory for intertwined orders and hole pockets in the cuprates AI翻译
  作者：Pandey, Harshit; Christos, Maine; Bonetti, Pietro M.; Shanker, Ravi; Sharma, Sayantan; Sachdev, Subir
  作者单位：Institute of Mathematical Sciences (IMSc) India; Homi Bhabha National Institute; Harvard University; California Institute of Technology; Max Planck Society; Simons Foundation; Flatiron Institute; Abdus Salam International Centre for Theoretical Physics (ICTP)
  摘要：The cuprate pseudogap phase displays Fermi arc spectral weight in photoemission and scanning tunneling microscopy, while recent magnetotransport observations yield evidence for the existence of hole pockets of fractional area p/8, where p is the doping density. We present a Monte Carlo study of a thermal SU(2) lattice gauge theory which can reconcile these observations. Our simulation includes the SU(2) gauge field U of a pi-flux spin liquid, and a SU(2) fundamental charge e Higgs boson B. The...