18期

最新文章

• Regulation of Tmem30b-mediated apical membrane homeostasis in auditory outer hair cells is critical for hearing AI翻译
  作者：Chang, Miao; Hong, Guodong; Gao, Shan; Cheng, Cheng; Yuan, Jia; Xiao, Yu; Qiao, Ruifeng; Ke, Jing; Wu, Xinhao; Zhang, Tiancheng; Guo, Siwei; Jiang, Runze; Liu, Ziyi; Zhou, Jing; Zhang, Xiaohan; Wu, Yunhao; Zhao, Xiaoxu; Li, Wen; Shen, Shuyuan; He, Zuhong; Bi, Xiuli; Chai, Renjie; Fu, Xiaolong
  作者单位：Beijing Institute of Technology; Shandong First Medical University & Shandong Academy of Medical Sciences; Southeast University - China; Shandong University of Traditional Chinese Medicine; Wuhan University; Southeast University - China
  摘要：Mechanotransduction within the cochlea depends on the precise architecture of hair bundles, yet our comprehension of the mechanisms that govern the formation and maintenance of the sound-receptive structure is still limited. Here, we identify Tmem30b, a phospholipid-flippase chaperone, as a critical regulator expressed in outer hair cells (OHCs). Although initially localized to the nuclear membrane at P5, Tmem30b translocates to and stabilizes within the stereocilia and the underlying cuticula...
• A few key species drive community thermophilization under experimental warming AI翻译
  作者：Dobson, Kara C.; Zhu, Kai; Song, Yiluan; Zhu, Jiali; Adler, Peter B.; Stemkovski, Michael; Montgomery, Rebecca; Stefanski, Artur; Worm, Kally; Reich, Peter B.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Utah System of Higher Education; Utah State University; Utah System of Higher Education; Utah State University; University of Minnesota System; University of Minnesota Twin Cities; University of Wisconsin System; University of Wisconsin Stevens Point
  摘要：Community thermophilization-the process by which communities are increasingly dominated by species from warmer biogeographic regions-is a widespread ecological response to warming. However, most studies on thermophilization use observational data, making it difficult to directly attribute warming as the driver of thermophilization. Furthermore, knowledge of specific species that are key drivers of thermophilization may be especially relevant to natural resource management and restoration pract...
• An auxin-induced transcriptional cascade CmBES1-CmSAUR66 orchestrates the ray floret development in Chrysanthemum morifolium AI翻译
  作者：Jia, Diwen; Zhang, Yuhang; Su, Jiangshuo; Wang, Jiaqi; Zhang, Weiming; Li, Song; Ma, Libang; Jiang, Jiafu; Chen, Sumei; Ding, Lian; Chen, Fadi
  作者单位：Nanjing Agricultural University
  摘要：Sympetaly (fused petals) is a key morphological innovation that has arisen multiple times during evolution. It occurs via one of two developmental pathways: late sympetaly (from initially separate petal primordia that later fuse) or early sympetaly (directly from a shared ring-like primordium). Nevertheless, the genetic basis of corolla tube formation in early-sympetalous lineages remains largely unknown. In Chrysanthemum morifolium, an early-sympetalous species, ray floret corolla tube format...
• Strong intrinsic multiferroism and magnetoelectric coupling in (1-x)BiFeO3-(x)BaTiO3 films AI翻译
  作者：Kim, Tae Yeon; Schimpf, Jesse; Paul, Atanu; Xu, Michael; Samanta, Atanu; Husain, Sajid; Meisenheimer, Peter; Harris, Isaac; Finkel, Peter; Mion, Thomas; Staruch, Margo; Ruffino, Anthony J.; Masiuk, Stefan; Wu, Liyan; Park, Tae Joon; Kang, Deokyoung; Klewe, Christoph; Stevenson, Paul; Ramesh, Ramamoorthy; Rappe, Andrew M.; LeBeau, James M.; Spanier, Jonathan E.; Grinberg, Ilya; Martin, Lane W.
  作者单位：Rice University; Rice University; University of California System; University of California Berkeley; Bar Ilan University; Massachusetts Institute of Technology (MIT); University of Pennsylvania; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; Drexel University; Drexel University; Korea University; Northeastern University; Rice University; Rice University
  摘要：The coexistence of ferroelectric and antiferromagnetic order in BiFeO3 makes it promising for next-generation magnetoelectric devices. But, single-phase multiferroics with robust room-temperature polarization and magnetization are rare. Here, enhanced, room-temperature ferroelectric polarization (approximate to 120 & micro;C cm-2), saturation magnetization (approximate to 40 emu cm-3), and strong magnetoelectric coupling (approximate to 400 mV cm-1 Oe-1) are observed in epitaxial (1-x)BiFeO3-(...
• Spontaneous Coulomb fissions of drops on lubricated surfaces AI翻译
  作者：Lin, Marcus; Zhang, Peng; Ratschow, Aaron D.; Li, Oscar; Arunachalam, Sankara; Daniel, Dan
  作者单位：King Abdullah University of Science & Technology; Okinawa Institute of Science & Technology Graduate University; Max Planck Society
  摘要：Charged water drops are more widespread than commonly acknowledged. For example, raindrops typically carry charges of order Q similar to 1 pC, while routine pipetting in the laboratory produces drops with Q similar to 50 pC. Here, we show that such modest charging can spontaneously generate periodic Coulomb fissions for evaporating water drops on lubricated surfaces, with more than 60 successive cycles observed over 30 min. Interestingly, the underlying instability can be quantitatively predic...
• A millennium of cold-water coral habitat loss in the East Pacific during low ENSO variability in the mid- to late Holocene AI翻译
  作者：Stewart, Joseph A.; Robinson, Laura F.; Taylor, Michelle L.; Fornari, Daniel J.; Robert, Katleen; Banks, Stuart; Chen, Tianyu; Li, Tao; Kershaw, James; Hoy, Shannon; Liu, Qian; Gordon, Jessica D.; de Carvalho Ferreira, Maria Luiza; Samperiz, Ana; Shen, Yingchu; Sun, Yun-Ju; Wang, Maoyu
  作者单位：University of Bristol; University of York - UK; University of Essex; Woods Hole Oceanographic Institution; Memorial University Newfoundland; Nanjing University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; University of Chicago; State University System of Florida; Florida State University; Cardiff University; University of St Andrews
  摘要：The evolution of El Nino-Southern Oscillation (ENSO) under past and future climate change and its influence on marine ecosystems is highly debated. To examine links between tropical climate variability, high-latitude feedbacks, and deep-sea ecosystems, we have analyzed over 900 subfossil cold-water scleractinian corals from the Galapagos Archipelago. U-Th dating shows that these corals have inhabited the region for at least 117,000 y, thriving at depths down to similar to 1,000 m. However, we ...
• Pseudorabies virus triggers ferritinophagy-mediated ferroptosis and neuroinflammation in viral encephalitis AI翻译
  作者：Sun, Jiali; Huo, Caiyun; Li, Yuli; Li, Xinsen; Xu, Jiawei; Tian, Jijing; Xiao, Jin; Zhang, Rui; Han, Jun; Zhou, Lei; Hu, Yanxin; Yang, Hanchun
  作者单位：China Agricultural University
  摘要：Pseudorabies virus (PRV), a member of the Alphaherpesvirinae subfamily, primarily infects pigs and poses a significant threat to the swine industry. In recent years, emerging PRV variants have been reported to infect humans, predominantly causing encephalitis. Ferroptosis is a recently identified form of programmed cell death, characterized by iron-dependent lipid peroxidation. It has been implicated in the pathogenesis of various diseases, including neurodegenerative disorders and viral infec...
• Quantitative assessment of flow between cerebrospinal and interstitial fluid compartments in humans AI翻译
  作者：Wahlin, Anders; Behndig, Sofia; Eriksson De Ryst, Johan; Vigren Naslund, Viktor; Dahlgren Lindstrom, Daniel; Axelsson, Jan; Bjornfot, Cecilia; Bylund, Mikael; Garpebring, Anders; Holmlund, Petter; Lalou, Afroditi; Mogensen, Klara; Nilsson, Daniel P. G.; Qvarlander, Sara; Soderstrom, Pontus; Vikner, Tomas; Wiklund, Krister; Andersson, Magnus; Riklund, Katrine; Malm, Jan; Eklund, Anders
  作者单位：Umea University; Umea University; Umea University; Umea University; Umea University; Umea University; University of Wisconsin System; University of Wisconsin Madison; Umea University
  摘要：According to glymphatic system theory, cerebrospinal fluid (CSF) perfuses the brain's interstitial space to support waste clearance, but the magnitude of this flow and the outflow pathway of interstitial fluid (ISF) in humans remain uncertain. To achieve flow quantification, we applied a compartment-model approach applied in conjunction with serial quantitative MRI data acquired after intrathecal gadolinium administration. Using the method, we estimated CSF-to-ISF inflow to 45 +/- 20 mL/h, in ...
• Erythroferrone derived from osteoblasts regulates stress erythropoiesis AI翻译
  作者：Na-Phatthalung, Pinanong; van Caloen, Gabrielle; Planoutene, Marina; Tai, Emily; Gumerova, Anisa; Witztum, Ronit; Ingber, Eva; Kautz, Leon; Sultana, Farhath; Korkmaz, Funda; Levy, Maayan; Yuen, Tony; Zaidi, Mone; Ginzburg, Yelena Z.
  作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Institut National de la Sante et de la Recherche Medicale (Inserm); Communaute d'universites et etablissements de Toulouse (Comue)
  摘要：Erythroferrone (ERFE), secreted by erythroblasts, is regarded as a classical regulator of iron metabolism through its suppression of hepcidin. Thus, as a consequence of insufficient hepcidin suppression and reduced iron availability, global Erfe - / - mice exhibit delayed recovery after phlebotomy. We have shown previously that, apart from erythroblasts, ERFE is notably expressed in osteoblasts. To explore the effect specifically of osteoblast-derived ERFE during stress erythropoiesis, we firs...
• Resource availability structures microbial competition through genomic niche partitioning AI翻译
  作者：Santos-Junior, Celio Dias; Escobar, Maria Camila; Huber, Paula; Nino-Garcia, Juan Pablo; Cardona, Gladys Ines; Costa-Pereira, Raul; Sarmento, Hugo
  作者单位：Hubei Hongshan Laboratory; Huazhong Agricultural University; Universidade Federal de Sao Carlos; Universidad de Antioquia; National University of the Littoral; Universidade Estadual de Campinas
  摘要：Microbial competition for scarce resources shapes biodiversity patterns and ecosystem function across global biomes, yet quantifying this process from genomic data has remained elusive. Here, we introduce CaCo, a scalable metric that transforms metagenomic carbohydrate-active enzyme profiles into precise measures of niche overlap and competition potential (Resource Partitioning Score, RPS). Analyzing 14,691 high-quality metagenome-assembled genomes spanning Ocean, freshwater, soil, and human g...