18期

最新文章

• Unveiling the glymphatic system's role in brain aging: A comprehensive biomarker and modifiable intervention target AI翻译
  作者：Fang, Yuanyuan; Luo, Wenxi; Huang, Hao; Ran, Lusen; He, Yuqin; Cheng, Chang; Yao, Yao; Hou, Yuxiang; Zheng, Haibo; Pan, Dengji; Xu, Shabei; Luo, Xiang; Qin, Tingting; Hao, Xingjie; Lu, Feng; Wang, Wei; Wang, Minghuan
  作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology
  摘要：The focus of this study is to investigate the role of diffusion tensor imaging along the perivascular space (DTI-ALPS) index in brain aging. To address this, we first examined the association of DTI-ALPS with aging hallmarks among 40,488 UK Biobank (UKB) participants. Next, we developed normative brain age models incorporating the DTI-ALPS index from 12,401 healthy UKB adults and validated in UKB-ADNI and UKB-TALENT datasets. Finally, we explored the relationship between brain age gap (BAG) wi...
• HIV-1 infection induces Vif-mediated SUMOylation of host RNA splicing factors important for proper viral RNA splicing AI翻译
  作者：Kelenis, Demetra P.; Johnson, Jeffrey R.; Sidoli, Simone; Emery, Ann; Swanstrom, Ronald; Hawkins, Luke J.; Mckie, Kaila; Pawar, Tegh; Goff, Stephen P.
  作者单位：Columbia University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Yeshiva University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Columbia University
  摘要：SUMOylation is a dynamically regulated post-translational modification involving covalent attachment of small ubiquitin-like modifiers (SUMOs) to lysine residues of target proteins. SUMOylation modulates multiple fundamental host cellular pathways, including pathways hijacked by HIV-1 to enable replication, but has not been explored by large-scale proteomics in the context of HIV-1 infection. Here, we performed a proteome-wide, mass spectrometry-based screen to identify proteins that are SUMOy...
• Parallel algorithms for phylogenetic inference under a structured coalescent approximation AI翻译
  作者：Shao, Yucai; Suchard, Marc A.; Rambaut, Andrew; Ji, Xiang; Lemey, Philippe; Vasylyeva, Tetyana I.; Baele, Guy
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of Edinburgh; Iowa State University; KU Leuven; University of California System; University of California Irvine
  摘要：Advances in molecular epidemiology and computational modeling have improved our ability to track pathogen evolution, but accurate reconstruction of spatiotemporal transmission remains essential for epidemic preparedness and response. Structured coalescent models offer a phylogeographic framework by restricting coalescence to lineages within the same deme. Although the Bayesian structured coalescent approximation (BASTA) provides a tractable approach, contemporary phylogeographic analyses invol...
• Exercise works-if mitochondria do AI翻译
  作者：Xu, Jianing
  作者单位：Regeneron
• Kinetochore proteins control microtubule dynamics in postmitotic neurons to regulate the formation of dendritic spines AI翻译
  作者：Zhao, Guoli; Sharma, Aditi; Tang, Jing; Aleman, Martina; Liang, Xing; Miner, Lauren; Qi, Jingqi; Xiang, Wangchu; Tian, Feng; Goldberg, Yves; He, Zhigang; Shen, Kang; Peris, Leticia; Schwarz, Thomas L.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; CEA; Communaute Universite Grenoble Alpes; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Grenoble Alpes (UGA); Stanford University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Stanford University; Stanford Medicine; Howard Hughes Medical Institute
  摘要：Kinetochore proteins, long studied for their role in cell division, are also required for the proper postmitotic development of hippocampal and cortical neurons. Proteins of the kinetochore complex were present in axons and dendrites of postmitotic iNeurons where they resided, at least in part, at microtubule plus ends. Conditional deletion of mouse Ndc80 or Dsn1 increased the number of dendritic spines. Loss of any of three kinetochore components (Ndc80, Dsn1, or Mis12) increased microtubule ...
• Live-cell 3D-SIM of Rift Valley fever virus NSs filaments reveals a polygon web architecture (vol 123, e2534404123, 2026) AI翻译
  作者：Dunlop, James I.; Thomason, Peter A.; Carlin, Leo M.; Davis, Benjamin G.; Carter, Stephen D.
• High-rate quantum key distribution with compact state preparation and detection AI翻译
  作者：Fan-Yuan, Guan-Jie; Xie, Wei-Xin; He, De-Yong; Huang, Xiao-Juan; Wang, Shuang; Yin, Zhen-Qiang; Chen, Wei; Li, Qiong; Mao, Hao-Kun; Zhang, Guo-Wei; Wang, Yu-Long; Guo, Guang-Can; Han, Zheng-Fu
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; CAS Center for Excellence in Quantum Information & Quantum Physics; Chinese Academy of Sciences; University of Science & Technology of China, CAS; CAS Center for Excellence in Quantum Information & Quantum Physics; Hefei National Laboratory; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Harbin Institute of Technology
  摘要：Quantum key distribution (QKD) is a promising technology for information-theoretic secure communications. The practicality of QKD systems is critical for large-scale network deployment, requiring both high key generation rate and miniaturized modules for quantum-state preparation and detection. Here, we report a deployable QKD system that achieves secure key rates of 60.33 +/- 0.03 Mbps at 10 km and 3.08 +/- 0.20 Mbps at 100 km. The system integrates a dual-parallel Mach-Zehnder encoder to ach...
• Iron supply from the Oregon margin to the ocean dominated by hypoxia-dependent particles AI翻译
  作者：Floback, Alexis E.; Pham, Anh Le-Duy; Damien, Pierre; Odendahl, Catherine E.; Weiske, Jennifer; Thomas, Katherine E.; Gaffney, Justin; John, Seth G.; Bianchi, Daniele; Moffett, James W.
  作者单位：University of Southern California; University of Hawaii System; University of Hawaii Manoa; University of California System; University of California Los Angeles; University of Southern California; University System of Maryland; University of Maryland Center for Environmental Science
  摘要：Continental margins are sources of iron (Fe), a critical oceanic micronutrient limiting productivity over nearly a third of the ocean. Paradoxically, they are also sinks of Fe and other particle-reactive elements that are sequestered in margin sediments. When dissolved Fe is released from reducing sediments, most is retained on the shelf by oxidative scavenging (Fe trapping), severely constraining cross-shelf export of dissolved Fe. However, observations from the Oregon shelf in 2021 show that...
• Ab initio molecular dynamics prediction and experimental validation of the 14:4 rare-earth oxide-phosphate structure AI翻译
  作者：Hong, Qi-Jun; Ushakov, Sergey V.; Wang, Ligen; Burkmann, Konrad; Matteucci, Jared; Wu, Jun; Fitch, Andrew; Witharamage, Chathuranga S.; Xu, Hongwu; Opila, Elizabeth J.; Glaum, Robert; Navrotsky, Alexandra
  作者单位：Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; European Synchrotron Radiation Facility (ESRF); University of Virginia; University of Bonn
  摘要：Rare-earth oxide-phosphates (historically termed oxyphosphates) occupy the compositional space between RE2O3 and REPO4 and form during REPO4 melting and high-temperature degradation of REPO4-based environmental barrier coatings. For several reported stoichiometries, reliable structural models remain unavailable because these phases are low-symmetry, large-unit-cell compounds that seldom form crystals suitable for single-crystal X-ray diffraction. Here, we predict the crystal structure of the c...
• AR-targeted therapies sensitize prostate cancer to cuproptosis by transcriptionally activating FDX1 AI翻译
  作者：Li, Xuehui; Wang, Siliang; Wei, Yuang; Xie, Chuang; Chen, Yanhua; Wu, Fanchen; Zhou, Qianqian; Song, Xiaowen; Xu, Xinyi; Xu, Dongliang; Xu, Lingfan; Lin, Shan; Yuan, Fuwen
  作者单位：Shanghai University of Traditional Chinese Medicine; Shanghai University of Traditional Chinese Medicine; Shanghai University of Traditional Chinese Medicine; Anhui Medical University
  摘要：Androgen receptor (AR) signaling is central to prostate cancer progression, yet resistance to AR-targeted therapies remains a major clinical challenge. Understanding the molecular consequences of AR pathway inhibition is therefore essential for improving therapeutic outcomes. Here, we identify a previously unrecognized link between AR antagonism and cuproptosis, a copper-dependent form of regulated cell death. Using integrated genomic profiling, we find that AR-targeted agents transcriptionall...