18期

最新文章

• An inverse correlation between structural linguistic and human genetic diversity AI翻译
  作者：Graff, Anna; Ringen, Erik J.; Zakharko, Taras; Stoneking, Mark; Shimizu, Kentaro K.; Bickel, Balthasar; Barbieri, Chiara
  作者单位：University of Zurich; University of Zurich; University of Zurich; Max Planck Society; VetAgro Sup; Universite Lyon 1; Centre National de la Recherche Scientifique (CNRS); Yokohama City University; University of Cagliari
  摘要：Linguistic structures show uneven global distributions, but it remains unknown to what extent such distributions are driven by human population history at a global scale. Here, we track population history through population genetics and show that, adjusting for geography, phylogeny, and environment, genetic diversity (in terms of local homozygosity modeled across individuals) is inversely correlated with linguistic diversity (in terms of local entropy of structural features modeled across lang...
• Structural basis of iron piracy by human gut Bacteroides AI翻译
  作者：Silale, Augustinas; Soo, Yung Li; Mark, Hannah; Motz, Rachel N.; Basle, Arnaud; Nolan, Elizabeth M.; van den Berg, Bert
  作者单位：Newcastle University - UK; Massachusetts Institute of Technology (MIT)
  摘要：Iron is an essential element that can be growth-limiting in microbial communities, particularly those present within host organisms. To acquire iron, many bacteria secrete siderophores, secondary metabolites that chelate ferric iron. These iron chelates can be transported back into the cell via TonB-dependent transporters in the outer membrane, followed by intracellular liberation of the iron. Pathogenic Escherichia coli and Salmonella produce siderophores during gut infection. In response to ...
• Restoring the 14-3-3/CRAF regulatory interaction in Noonan syndrome using molecular glues AI翻译
  作者：Virta, Johanna M.; Vickery, Holly R.; Konstantinidou, Markella; Crawford, Mckenna C.; Pennings, Marloes A. M.; Ottmann, Christian; Brunsveld, Luc; Arkin, Michelle R.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; Eindhoven University of Technology; Eindhoven University of Technology
  摘要：Noonan syndrome (NS) is the most common RASopathy, a developmental disorder that derives from dysregulation of the mitogen-activated protein kinase (MAPK) pathway. NS results from modestly activating mutations in proteins throughout the pathway. Trametinib, a MEK inhibitor, has shown promising results for certain NS complications, but NS-specific therapeutic options are lacking. CRAF activity, which is governed by the adaptor protein 14-3-3, represents a key NS regulatory node that has not bee...
• Multimodal analysis reveals cellular diversity and divergent circuits of the zona incerta AI翻译
  作者：Kast, Ryan; Simmons, Sean K.; Rome, Nita; Adiconis, Xian; Melamed, Lisa; McCabe, Kathryn A.; Wang, Dongqing; Krol, Alexandra; Krubner, Magdalena; Prevosto, Vincent; Levandowski, Kirsten; Sabbagh, Ubadah; Sullivan, Heather A.; Wickersham, Ian R.; Wang, Fan; Levin, Joshua Z.; Fu, Zhanyan; Feng, Guoping
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：The zona incerta (ZI) plays an important role in diverse behavioral functions and is an emerging clinical target for deep brain stimulation to treat neurological conditions. Despite their importance, the cell type composition of the ZI and the anatomical circuit organization linking specific ZI cell types to brain-wide circuits remain unclear. In this study, we used single-nucleus RNA-sequencing, spatial RNA profiling, ex vivo electrophysiology, and anatomical circuit mapping to generate a mul...
• Context-dependent variability of HIF heterodimers influences interactions with macromolecular and small molecule partners AI翻译
  作者：Closson, Joseph D.; Xu, Xingjian; Zhang, Meiling; Tiyani, Tarsisius T.; Marcelino, Leandro Pimentel; Isiorho, Eta A.; Nagati, Jason S.; Garcia, Joseph A.; Gardner, Kevin H.
  作者单位：City University of New York (CUNY) System; City University of New York (CUNY) System; City University of New York (CUNY) System; Columbia University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; US Department of Veterans Affairs; Veterans Health Administration (VHA); James J. Peters VA Medical Center; US Department of Veterans Affairs; Veterans Health Administration (VHA); James J. Peters VA Medical Center; City University of New York (CUNY) System
  摘要：Hypoxia inducible factors (HIFs) are heterodimeric transcription factors that coordinate cellular responses to low oxygen levels by binding a short hypoxia response element (HRE) DNA sequence near O2-regulated genes. Prior studies suggest HIF/HRE complexes are augmented by the binding of additional factors nearby, but those interactions are not well understood. Here, we integrated structural and biochemical approaches to investigate several functionally relevant HIF assemblies with other prote...
• Exploring PrPc unfolding as a critical step preceding its refolding in the context of PrPSc propagation AI翻译
  作者：Sabzehei, Sanaz; Rigoli, Marta; Cacheiro, Raul; Diaz-Arias, Iria; Erana, Hasier; Lago, Ruben P.; Guerra, Arcadio; Rezaei, Human; Castilla, Joaquin; Biasini, Emiliano; Sanchez-Pedregal, Victor M.; Martin-Pastor, Manuel; Requena, Jesus R.
  作者单位：Universidade de Santiago de Compostela; Complexo Hospitalario Universitario de Santiago de Compostela; Universidade de Santiago de Compostela; University of Trento; Universidade de Santiago de Compostela; CiQUS; Universite Paris Saclay; INRAE; Basque Foundation for Science; Universidade de Santiago de Compostela; Universidade de Santiago de Compostela
  摘要：It might have been believed that elucidation of the atomistic structure of PrPSc would lead to an immediate understanding of the mechanism of prion propagation. However, PrPSc, now known to be a simple amyloid, can only template a previously unfolded polypeptide chain. Therefore, PrPSc can easily template the disordered similar to 90-120 domain of an incoming PrPc molecule, but not its similar to 121-231 folded domain (FD). The FD needs to accommodate into the similar to 121-230 PrPSc surface,...
• Reply to Huang and Dong: Circuit insights unlock translational potential of peripheral electroacupuncture for epilepsy AI翻译
  作者：Wang, Yu; Zhang, Qingyang; Wang, Yi; Chen, Zhong
  作者单位：Zhejiang Chinese Medical University
• Neural correlates of perceptual decision-making in the primary somatosensory cortex AI翻译
  作者：Armstrong, Alex G.; Vlasov, Yurii
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Chan Zuckerberg Initiative (CZI)
  摘要：The brain is thought to produce decisions by gradual accumulation of sensory evidence through a hierarchically organized feedforward cascade of neuronal activities that transforms early stimulus representations in the primary somatosensory cortex (S1) to a perceptual decision processed in premotor areas. Recently, this prevailing view has been challenged by observation of choice-correlated neural activity as early in the hierarchy as S1. Here, to reconcile these seemingly controversial observa...
• The antimetastatic effects of calorie restriction are negated by voluntary exercise in an aggressive breast cancer mouse model AI翻译
  作者：Garrido, Amanda; Tamayo-Torres, Eva; Abdo, Sara; Durham, Ethan; Hirschenson, Jonathan; Tanaka, Hikari; Duregon, Eleonora; Ozturk-Gurgen, Hazal; Kovour, Mounisha; Bodogai, Monica; Biragyn, Arya; Camandola, Simonetta; Price, Nathan L.; Bernier, Michel; Carretero, Julian; Gomez-Cabrera, Maria Carmen; de Cabo, Rafael
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); University of Valencia; University of Valencia; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
  摘要：The role of lifestyle interventions in treatment success has become essential for nearly every disease. Healthy dietary habits, regular exercise, and stress management are key pillars that can improve quality of life during treatment, as well as delay disease onset and progression. In this study, we focus on the combination of mild calorie restriction (CR) and voluntary exercise as coadjuvants to chemotherapy in the treatment of triple-negative breast cancer using the 4T1 mouse model. In this ...
• Perception of a bacterial quorum sensing signal activates a tripartite plant immune strategy AI翻译
  作者：He, Danxia; Zhou, Yang; Li, Meng; Wang, Miao; Yu, Wenjia; Shao, Chuyang; Singh, Sunil Kumar; Gu, Meijiao; Wang, Yuhua; Yuan, Jianlong; Wu, Xiaoxuan; Zheng, Shuai; Xie, Yi; Chen, Lixian; Morcillo, Rafael J. L.; Yang, Yu; Vilchez, Juan Ignacio; Zhang, Jin-Lin; Miao, Yansong; Macho, Alberto P.; Zhang, Huiming
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Nanyang Technological University; Fujian Medical University; Lanzhou University; Chinese Academy of Sciences; Eastern Institute of Technology, Ningbo
  摘要：Bacterial quorum sensing (QS) signals an increasing threat during pathogenesis. How plants deploy timely defenses through QS perception is poorly understood. Here, we report that Arabidopsis thaliana perceives 2'-aminoacetophenone (2'-AA), a volatile QS signal from Pseudomonas aeruginosa , and mounts a multilayered defense. This response comprises BRI1-ASSOCIATED RECEPTOR KINASE 1 (BAK1)-dependent intracellular immunity, extracellular quorum quenching through the release of acetic acid, and ec...