-
作者：Wang, Yusha; Han, Xu; Wang, Libo; Wang, Jinbo; Wang, Qintao; Xiong, Wen; Yang, Jun; Guo, Li; Qi, Lingli; Dong, Wei; Yang, Huanming; Yu, Xiaomin; Zhou, Qing
作者单位：Zhejiang University; Liangzhu Laboratory; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS; Jilin University; Zhejiang University; China Medical University; Zhejiang University; Beijing Genomics Institute (BGI)
摘要：Toll-like receptor 1 (TLR1), a member of the TLR family, assumes a pivotal role in pathogen recognition and the activation of innate immunity. In this study, we have identified a homozygous truncating TLR1 variant associated with immune dysregulation and colitis. Peripheral blood mononuclear cells derived from the patient manifested robust inflammatory signatures and defective TLR1 signaling responses. TLR1-deficient cells demonstrated impaired production of a wide-spectrum of inflammatory cyt...
-
作者：Ma, Qian; Cai, Yongfeng; Zhang, Zhidan; Zhao, Dingwei; Zhao, Yuan; Xu, Peishan; Lu, Tammy; Zhang, Wendy; Yang, Qiuhua; Zhou, Yaqi; Sudhahar, Varadarajan; Fukai, Tohru; Jo, Hanjoong; Xu, Yiming; Huo, Yuqing
作者单位：Baylor College of Medicine; Anhui Medical University; Guangzhou Medical University; State University of New York (SUNY) System; Stony Brook University; Guangzhou University of Chinese Medicine; University System of Georgia; Augusta University; Emory University; University System of Georgia; Georgia Institute of Technology
摘要：Despite effective lipid-lowering therapies, atherosclerosis continues to be a leading cause of death, with considerable residual cardiovascular risk. Atherosclerotic lesions develop preferentially at arterial regions exposed to disturbed flow (d-flow), which induces genomic stress, endothelial injury, and barrier dysfunction. Hemodynamic forces are known to reprogram endothelial metabolism, but the role of de novo purine synthesis (DNPS), which supplies nucleotides for genome maintenance and w...
-
作者：Naruse, Kiyoshi; Takeda, Hiroyuki
作者单位：National Institutes of Natural Sciences (NINS) - Japan; National Institute for Basic Biology (NIBB); Kyoto Sangyo University
-
作者：Berestycki, Clara; Chen, M. Keith
作者单位：Columbia University; University of California System; University of California Los Angeles
摘要：Although wildfire smoke is a major public health concern, relatively little is known about individual avoidance behavior. In this paper, we use smartphone-location data to study behavioral responses to smoke during the 2018 California wildfire season, one of the deadliest in recent US history. Using individual-level data, we construct daily measures of when and where California residents spend their time. We find that high levels of smoke increase time spent at home and indoors, while decreasi...
-
作者：Koopmans, Lars; de Roos, Andre M.; Martin, Benjamin T.
作者单位：University of Amsterdam; The Santa Fe Institute
摘要：Pursuit and evasion dynamics are a general phenomenon observed in predator-prey interactions across terrestrial, aquatic, and aerial domains. Differences in body mass and domain generate variation in biomechanical traits that shape these encounters, yet the consequences of such variation remain poorly understood. Here, we integrate allometric scaling relationships of vertebrate locomotion with turning gambit theory, a geometrical model of pursuit-evasion, to examine how body size and domain sh...
-
作者：Wang, Qian; Chen, Min; Lasram, Asma; Vihuri, Saana; Chou, Angela Z.; Bian, Weixin; Dai, Zhiming; Haapanen, Outi; Enkavi, Giray; Pollmann, Christoph; Vattulainen, Ilpo; Cai, Tiantian; Piehler, Jacob; Chou, James J.
作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Chinese Academy of Sciences; University Osnabruck; University Osnabruck; University of Helsinki; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Zhejiang University
摘要：Mutations within the transmembrane domains (TMDs) of single-pass transmembrane receptors often cause aberrant, ligand-independent receptor signaling associated with diverse malignancies, but their mechanism of action remains largely unknown. These TMD mutations are generally not targetable as they are buried in the membrane. Here, we determined the mechanism of a gain-of-function (GOF) TMD mutation of interleukin-7 receptor (IL-7R) associated with T cell acute lymphoblastic leukemia and addres...
-
作者：Huse, Morgan
作者单位：Memorial Sloan Kettering Cancer Center
-
作者：Peeters, Jan; Winkels, Timotheus G.; Wolf, Pawel; Skuldbol, Tim B. B.; Chamberlain, Elizabeth L.; Buchner-Matthews, Saskia; Elamin, Sami M.; Mohamed, El-Hassan A.; Emberling, Geoff
作者单位：University of Michigan System; University of Michigan; Wageningen University & Research; Wageningen University & Research; University of Michigan System; University of Michigan
摘要：The Nile River played a central role in ancient civilizations of Northeast Africa, yet its response to Holocene climate change and its impact on societies along its course remain poorly understood. Here we show how climatic and environmental changes over the past 12,500 y shaped the riverine landscape below the Nile's Fourth Cataract and affected the Nubian empire of Kush in northern Sudan. Using 26 sediment cores dated by optically stimulated luminescence and radiocarbon, with additional chro...
-
作者：Xian, Xiaofeng; Zhang, Huaqiao; Xiao, Shuhai; Waloszek, Dieter; Maas, Andreas; Duan, Baichuan
作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Virginia Polytechnic Institute & State University; University of Munich; First Institute of Oceanography, Ministry of Natural Resources
摘要：Unambiguous body fossils of annelids (ringed worms) first appear in the Cambrian Period but are so far known exclusively as flattened specimens preserved in Burgess Shale-type Lagerst & auml;tten. Here, we report phosphatized microfossils, interpreted as polychaete annelids, from a distinct taphonomic window (i.e., three-dimensional Orsten-type preservation) in the earliest Cambrian (early Fortunian Age, ca. 535 Ma) Zhangjiagou Lagerst & auml;tte of South China. The fossils are millimetric in ...
-
作者：Marin-Aguilar, Susana; Zaccarelli, Emanuela
作者单位：Sapienza University Rome; Consiglio Nazionale delle Ricerche (CNR); Istituto dei Sistemi Complessi (ISC-CNR)
摘要：Ultra-low-crosslinked (ULC) microgels are among the softest colloidal particles nowadays routinely synthesized experimentally. Despite a growing literature of experimental results, their microscopic behavior under crowded conditions is yet to be revealed. To this aim, we resort to realistic monomer-resolved computer simulations to investigate their structural, mechanical, and dynamical properties across a wide range of packing fractions. Using particle-resolved analyses, we unveil the role of ...
