25期

最新文章

• Regulatory logic underlying neural crest contributions to the head versus the heart AI翻译
  作者：Gandhi, Shashank; Rajan, Ayyappa Raja Desingu; Urrutia, Hugo; Wilson, Jillian S.; Ling, Irving T. C.; Williams, Ruth; Sauka-Spengler, Tatjana; Bronner, Marianne E.
  作者单位：California Institute of Technology; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of Oxford; University of Oxford
  摘要：Neural crest cells exhibit axial-level-specific transcriptional programs, yet the regulatory mechanisms underlying their fate decisions remain unclear. Here, we investigate whether differential transcription factor usage governs cardiac neural crest cell identity. Comparing ATAC-seq profiles of cardiac and cranial neural crest revealed open chromatin regions that were both shared and region-specific. Single-cell RNA sequencing further identified putative target genes, including signaling molec...
• The dynamic mesoscale sink and source niches for eukaryotic phytoplankton in a subtropical gyre AI翻译
  作者：Jones-Kellett, Alexandra E.; McNichol, Jesse C.; Raut, Yubin; Fuhrman, Jed A.; Follows, Michael J.
  作者单位：Massachusetts Institute of Technology (MIT); Woods Hole Oceanographic Institution; University of Hawaii System; University of Hawaii Manoa; University of Southern California; Saint Francis Xavier University - Canada
  摘要：By tracking the water mass histories of genetic samples, we investigated the biophysical dynamics shaping eukaryotic phytoplankton populations in a nutrient-deplete subtropical gyre, where cyanobacteria have a competitive advantage. Triplicate seawater samples were filtered every similar to 46 km along a 2,382 km North Pacific transect, spiked with genomic internal standards, and amplified with a three-domain primer set to obtain absolute 16S and 18S rRNA volumetric gene abundances. The transp...
• Multidecadal preindustrial methane variability can be explained by noise in the source-sink imbalance AI翻译
  作者：Mei, Eric J.; Hakim, Gregory J.; Proistosescu, Cristian; Bauska, Thomas K.; Buizert, Christo; Turner, Alexander J.
  作者单位：University of Washington; University of Washington Seattle; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; Oregon State University
  摘要：Ice core records of preindustrial methane indicate variability of +/- 30 ppb (+/- 5%) on multidecadal-to-centennial timescales. Previous work has attributed these excursions to low-frequency or episodic changes in methane sources due to large-scale climate variability (e.g., the Little Ice Age) or human activity. Here, we explore what source and sink dynamics are consistent with ice core variability and show that the preserved variability can arise solely from white noise fluctuations in the s...
• Forests shaped by historical human tragedies: Insights from Europe's oldest angiosperms AI翻译
  作者：Pasques, Ot; Munne-Bosch, Sergi
  作者单位：University of Barcelona; University of Barcelona
• High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds AI翻译
  作者：Yang, Diwen; Wang, Xiaoyun; Liu, Jiabao; Gong, Yufeng; Nair, Pranav; Sun, Jianxian; Qian, Xing; Cui, Jingyuan; Zeng, Hong; Dong, Aiping; Harding, Rachel J.; Burgess-Brown, Nicola; Beyett, Tyler S.; Song, Datong; Krause, Henry M.; Diamond, Miriam L.; Bolhuis, Derek L.; Brown, Nicholas G.; Arrowsmith, Cheryl H.; Edwards, Aled M.; Halabelian, Levon; Peng, Hui
  作者单位：University of Toronto; University Toronto Scarborough; University of Toronto; University of Toronto; University of Toronto; Structural Genomics Consortium; University of Toronto; University of Toronto; University of London; University College London; Emory University; University of Toronto; University of Toronto; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto
  摘要：Chemical pollution is a global threat to human health, yet the toxicity mechanisms of most contaminants remains unknown. Here, we applied an ultrahigh-throughput affinity selection-mass spectrometry (AS-MS) platform to systematically identify protein targets of prioritized chemical contaminants. After benchmarking the platform, we screened 50 human proteins against 481 prioritized chemicals, including 446 ToxCast chemicals and 35 per- and polyfluoroalkyl substances (PFAS). Among 24,050 interac...
• Mathematical modeling of JAK2V617F clonal expansion in a general population cohort AI翻译
  作者：Snyder, Jordan; Andersen, Morten; Gudmand-Hoyer, Johanne; Larsen, Morten Kranker; Skov, Vibe; Kjaer, Lasse; Eickhardt-Dalboge, Christina Schjellerup; Knudsen, Trine A.; Ellervik, Christina; Hasselbalch, Hans C.; Ottesen, Johnny T.; Stiehl, Thomas
  作者单位：Roskilde University; North Carolina State University; University of Copenhagen; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; RWTH Aachen University; RWTH Aachen University
  摘要：The Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) are a group of blood cancers characterized by overproduction of one or more types of blood cells, which can lead to thrombosis and other complications. MPNs develop slowly and are driven by a relatively small set of mutations in the hematopoietic stem cells (HSCs). Their slow development (over the course of decades) affords a unique opportunity to study their onset, but until recently few data have been available from ind...
• AI agents are sensitive to nudges AI翻译
  作者：Cherep, Manuel; Maes, Pattie; Singh, Nikhil
  作者单位：Massachusetts Institute of Technology (MIT); Dartmouth College
  摘要：Large language models (LLMs) are increasingly deployed as autonomous agents that make choices and use tools on behalf of users. Yet, we have limited evidence about how their decisions are shaped by their environment. We adapt a human decision-making task to test leading LLMs under four forms of choice architecture: defaults, suggestions, information highlighting, and optimal nudges derived from a resource-rational model of human choice. We treat human behavior as a baseline for predictable sen...
• An atlas of microtubule lattice parameters regulated through ligand binding to the microtubule-stabilizing sites AI翻译
  作者：Lucena-Agell, Daniel; Fernandez, Oscar; Paris-Ogayar, Rebeca; Estevez-Gallego, Juan; Ondruskova, Denisa; Alvarez-Bernad, Beatriz; Bonato, Francesca; Larraga, Jaime; de Elguea, Diego Ortiz; Cano, Gregorio Javier; Scheers, Maarten; Imai, Hiroshi; Yagi, Toshiki; Iwamoto, Hiroyuki; Carlos Martinez-Guil, Juan; Singh, A. Jonathan; Keyzers, Robert Alexander; Vanderwal, Christopher D.; Altmann, Karl-Heinz; van der Eycken, Johan; Palomo, Valle; Fang, Wei-Shuo; Gago, Federico; Lansky, Zdenek; Braun, Marcus; Oliva, Maria A.; Kamimura, Shinji; Fernando Diaz, J.
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Investigaciones Biologicas (CIB); Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; University of Osaka; Victoria University Wellington; Victoria University Wellington; Victoria University Wellington; University of California System; University of California Irvine; University of California System; University of California Irvine; Swiss Federal Institutes of Technology Domain; ETH Zurich; Ghent University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Institute of Materia Medica - CAMS; Universidad de Alcala; Chuo University
  摘要：Microtubules are dynamic cytoskeletal polymers whose lattice architecture regulates force generation, nucleotide hydrolysis, and recognition by motor proteins and microtubule-associated proteins (MAPs). Microtubule-stabilizing agents (MSAs), including taxanes and laulimalide/peloruside-site ligands, suppress depolymerization by binding to defined lattice sites, yet stabilization is not structurally neutral. How ligand chemistry reshapes lattice organization and function remains unresolved. Her...
• A teleost-specific oxygen-immunity axis where FIH activates NF-κB via competitive IκBα binding AI翻译
  作者：Zhan, Zhipeng; Liang, Mincong; Yu, Yang; Cui, Yangchi; Li, Zhimin; Pan, Weiqiang; Zhou, Ziyi; Jiang, Lai; Hou, Yafeng; He, Jian; Wu, Kun; Weng, Shaoping; He, Jianguo; Guo, Changjun
  作者单位：Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Zhuhai); Sun Yat Sen University
  摘要：Global warming-induced aquatic deoxygenation poses a severe physiological challenge to teleosts, often influencing their immune defense mechanisms. While aquatic organisms are under evolutionary pressure to balance metabolic adaptation with pathogen resistance, the molecular strategies they employ to overcome high pathogen loads under hypoxic stress remain poorly understood. Here, an oxygen-immunity regulatory axis was identified in teleosts, in which the oxygen sensor FIH (factor inhibiting H...
• The archaeal roots of eukaryotic life (vol 123, e2516062123, 2026) AI翻译
  作者：De Anda, Valerie; Appler, Kathryn E.; Aguilar-Pine, Emily; Aitolo, Georgina L.; Halverson, Galen P.; Baker, Brett J.