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作者：Giraldo, Diego; Smith, Daniel F. Q.; Ortiz, Sebastien C.; Rankin-Turner, Stephanie; Gebhardt, Mary E.; Mwakibete, Lusajo; Chen, Ziyang; Ali, Renee L. M. N.; Norris, Douglas E.; Zhang, Sean X.; Casadevall, Arturo; McMeniman, Conor J.
作者单位：Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine
摘要：Insects and terrestrial fungi have lived on planet earth together for over 400 My. Different insect species are commonly associated with distinct mycobiomes. These insect-fungal associations are thought to provide a major dispersal mechanism for fungi in the environment. The Rhodotorula genus of pigmented basidiomycetous yeasts is commonly found in association with insects. Here, we demonstrate that yeasts of Rhodotorula spp. are highly attractive to the vinegar fly Drosophila melanogaster and...
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作者：Levitt, Michael; Marten, Ben; Oren, Gal; Ioannidis, John P. A.
作者单位：Stanford Medicine; Stanford University; Technion Israel Institute of Technology; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine
摘要：Death certificates record causes of death as reported by certifiers (Entity Axis) and as standardized by mortality coding rules (Record Axis). Conventional statistics reduce these to a single underlying cause, ignoring other contributing conditions; weighting schemes can instead distribute the burden across all listed causes. We evaluated reclassification from Entity to Record axis and weighting across all 56,986,831 US death certificates from 2003 to 2023, mapping International Classification...
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作者：Lin, Jason L. J.; Wu, Xiaoqi; Redweik, Graham A. J.; Chiu, Ching-Chi; Chiu, Tai-Ju; Chen, Yi-Ping; Webb, Kristofor J.; Rani, Rupal; Lee, Eui-Seung; Yang, Wei-Zen; Bhadra, Joyita; Stowell, Michael H. B.; Yuan, Hanna S.; Xue, Ding
作者单位：Academia Sinica - Taiwan; University of Colorado System; University of Colorado Boulder; Chang Gung University; Chang Gung Memorial Hospital
摘要：Mitochondrial endonuclease G (EndoG) is involved in several important cellular processes and has been implicated in multiple diseases. Accordingly, molecules modulating EndoG activity may have high therapeutic potentials. Searching for compounds affecting paternal mitochondrial elimination (PME) in Caenorhabditis elegans, we have identified resveratrol (RSV), a well-known natural compound, as a PME inhibitor. Interestingly, RSV exists as a mixture of trans- and cis-isomers, which interconvert ...
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作者：Noor, Salma; Jiang, Xun; Wang, Xinyue; Yang, Jiani; Newman, Sally; Li, King-Fai; Li, Liming; Yu, Le; Li, Xiyu
作者单位：University of Houston System; University of Houston; California Institute of Technology; University of California System; University of California Riverside; University of Houston System; University of Houston; Tsinghua University; Tsinghua University
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作者：Mishra, Avanish; Abelman, Rachel O.; Cunneely, Quinn; Putaturo, Victor; Deshpande, Akansha A.; Bell, Remy; Seider, Elizabeth M.; Xu, Katherine H.; Shan, Mythreayi; Kelly, Justin; Huang, Shih-Bo; Rieur, Olivia; Knape, Justine; Gopinathan, Kaustav A.; Kikkeri, Kruthika; Edd, Jon F.; Walsh, John; Dai, Charles S.; Ellisen, Leif W.; Ting, David T.; Nieman, Linda; Toner, Mehmet; Bardia, Aditya; Haber, Daniel A.; Maheswaran, Shyamala
作者单位：University of California System; UCLA Jonsson Comprehensive Cancer Center; University of California Los Angeles; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Howard Hughes Medical Institute
摘要：Antibody-drug conjugates (ADCs) target surface proteins on cancer cells, leading to internalization and delivery of a drug payload, thereby enhancing selectivity and minimizing toxicity. ADCs against TROP2 (Sacituzumab govitecan) or HER2 (T-DXd) have demonstrated efficacy in metastatic breast cancer, yet paradoxically, outside of HER2-amplified breast cancers, expression levels of these breast cancer-enriched epitopes in tumor biopsies have not been strongly correlated with clinical response. ...
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作者：Nemenman, Ilya; Mehta, Pankaj
作者单位：Emory University; Emory University; Emory University; Boston University; Boston University
摘要：Biologists and physicists have a rich tradition of modeling dynamics of living systems with simple models composed of a few interacting components. Despite the remarkable success of this approach, it remains unclear how to use such finely tuned models to study complex biological systems composed of numerous heterogeneous, interacting components. One possible strategy for taming this biological complexity is to embrace the idea that many biological behaviors we observe are typical and can be mo...
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作者：Wang, Bing; Chen, Dima; Wang, Shuaifei; Wu, Liji; Wu, Ying; Liu, Shengen; Delgado-Baquerizo, Manuel
作者单位：Inner Mongolia University; Fujian Agriculture & Forestry University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Recursos Naturales y Agrobiologia de Sevilla (IRNAS)
摘要：Soil parasitic protists influence the health of plants and soil organisms. Yet, the extent to which these interactions impact the stability of terrestrial ecosystems remains largely unquantified. Here, we utilized two independent global-scale biodiversity surveys available online to investigate the relationship between the taxonomic diversity of parasitic protists and satellite-based time series of ecosystem productivity (i.e., normalized difference vegetation index). We found that soil parasi...
