25期

最新文章

• ERK builds a population of short-lived nascent adhesions that produce persistent edge protrusion and cell migration AI翻译
  作者：Shepherd, Andrew P.; Carney, Keith R.; Rostami, Majid; Shawon, Jakaria; Elliott, Andrew; Samson, Shiela C.; Han, Sangyoon J.; Mendoza, Michelle C.
  作者单位：Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Huntsman Cancer Institute; Michigan Technological University
  摘要：Cell migration is realized through the fast and persistent protrusion of a leading edge in the direction of movement. The actin and adhesion structures that build edge protrusions are integrated such that pro-migration signaling pathways must control both assemblies to induce protrusion. Understanding the contribution of adhesion regulation has been complicated by the inability to selectively assay the nascent adhesions that promote edge protrusion. Here, we dissect how the core RAS -> RAF -> ...
• Drosophila Myc ameliorates defects in mitochondrial homeostasis and muscle maturation caused by Metaxin-2 deficiency AI翻译
  作者：Shou, Xinyi; Fan, Xiaoyu; Li, Ling; Ruan, Yina; Li, Wei; Shang, Weina; Mao, Jianhua; Xie, Xiaojun
  作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Liangzhu Laboratory; Zhejiang University
  摘要：Mitochondrial protein import machineries are essential for organelle homeostasis. Metaxin-2 (Mtx2) is an evolutionarily conserved component of the mitochondrial sorting and assembly machinery, and its mutations are associated with a progeroid syndrome, named mandibuloacral dysplasia associated to Mtx2 (MADaM). To investigate the pathologic mechanisms of MADaM, we developed Mtx2 genetic models in Drosophila. Mtx2 null mutants are lethal at a preadult stage, and this phenotype can be rescued by ...
• Targeting the DNA methylation-H3K27me3 switch reverses castration resistance and immunosuppression via ADAMTS1-driven collagenolysis AI翻译
  作者：Wu, Xiang; Song, Xiaoyi; Li, Bo; Yang, Yuchun; Li, Kunyu; Zhu, Jun; Li, Yawei; Yang, Xinming; Dai, Yingbo; Zhang, Zhuangzhuang
  作者单位：Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Anhui Medical University
  摘要：Castration-resistant prostate cancer (CRPC) lethality arises from epigenetic-driven resistance to androgen deprivation therapy (ADT). Here, we uncover a compensatory epigenetic switch between DNA methylation and H3K27me3-mediated repression as a critical barrier to epigenetic therapy in CRPC. Integrative multiomics analyses reveal that DNMT inhibitors (DNMTis) trigger EZH2-dependent H3K27me3 accumulation at the ADAMTS1 locus-a master collagenase essential for extracellular matrix (ECM) remodel...
• Computational design and cellular synthesis of two protein topological isomers: Solomon link vs. three-twist knot AI翻译
  作者：Xu, Lianjie; Song, Xiaohui; Xu, Hua; Wu, Wen-Hao; Su, Xiao-Dong; Zhang, Wen-Bin
  作者单位：Peking University; Chinese Academy of Sciences; Peking University; Peking University Shenzhen Graduate School (PKU Shenzhen); Peking University
  摘要：Chemical topology has emerged as a unique dimension in protein engineering, motivating the pursuit of topologically nontrivial protein architectures for functional advantages, such as enhanced stability and rich dynamics. However, the structural diversity of artificial mechanically interlocked proteins remains limited. Here, we report the computational design and cellular synthesis of a pair of topological isomers via symmetric assembly of orthogonal entangling motifs. By fusing two C2 symmetr...
• Revisiting dopamine function in cognition through abstract decision-making AI翻译
  作者：Puig, M. Victoria
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC)
• Canonical EDS1/PAD4 small-molecule binding sites are required for LRR-RP-mediated pattern-triggered immunity AI翻译
  作者：Fliegmann, Judith; Janocha, Denis; Hua, Chenlei; von Roepenack-Lahaye, Edda; Stahl, Mark; Locci, Federica; Parker, Jane E.; Nurnberger, Thorsten; Zhang, Lisha
  作者单位：Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Max Planck Society
  摘要：Pattern-triggered immunity (PTI) is a key plant defense mechanism initiated by the recognition of pathogen-associated molecular patterns (PAMPs) by cell-surface receptors, including leucine-rich repeat receptor proteins (LRR-RPs). Upon PAMP perception, LRR-RPs associate with SOBIR1 and recruit SERK coreceptors, such as BAK1, into the receptor complex to initiate PTI. The lipase-like protein EDS1 and PAD4 are central components of effector-triggered immunity (ETI). Small molecule (SM) phosphori...
• Overlap locking and nonperturbative effects in spin glasses AI翻译
  作者：Franz, Silvio; Parisi, Giorgio; Ricci-Tersenghi, Federico
  作者单位：Istituto Nazionale di Fisica Nucleare (INFN); University of Salento; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Beihang University; Istituto Nazionale di Fisica Nucleare (INFN); Sapienza University Rome
  摘要：We study the phenomenon of the locking of the order parameter (or synchronization) in spin glasses at low temperatures. When two systems with independent disorders are coupled, their overlaps become similar. A crucial question is how this effect depends on the strength of the coupling between the two systems. Nonperturbative phenomena are present when 1 <
• A magnesium efflux transporter required for seed development and eating quality in rice (vol 123, e2536813123, 2026) AI翻译
  作者：Huang, Sheng; Hori, Kiyosumi; Yamaji, Naoki; Yoshioka, Yuma; Ning, Min; Nagaya, Yu; Miyaji, Takaaki; Mitani-Ueno, Namiki; Inoue, Shin-ichiro; Kim, June-Sik; Kashino, Miho; Ma, Jian Feng
• Selectively targeting inosine monophosphate dehydrogenase-2 impairs brain metastatic potential while preserving immune cell function AI翻译
  作者：Kieliszek, Agata M.; Apel, Erika; Zheng, Suky; Piotrowski, Mathew; Chui, Danny; Alazet, Sebastien; Shamsi, Saeideh; Mobilio, Daniel; Johnson, Jarrod W.; Escudero, Laura; Vandevoorde, Kurt; Mei, Lin; Acevedo, Mariana; Sabbatani, Juliette; Kent, Oliver A.; Dordahan, Fatemeh; Yadav, Arun; MacKay, Bruce; Leguay, Kevin; Berger, Kathleen J.; Miletic, Petar; Zhai, Kui; Ang, Patrick; Huebner, Ariana; Chafe, Shawn C.; Sturino, Claudio; Szychowski, Janek; Venugopal, Chitra; Mancini, Joseph; Phinney, Amie L.; Magolan, Jakob; Singh, Sheila K.
  作者单位：McMaster University; McMaster University; McMaster University; Francis Crick Institute; University of London; University College London; University of London; King's College London
  摘要：Brain metastases (BM) occur in 26% of cancer patients and have a 90% mortality rate within 1 y of diagnosis, yet the current standard of care remains palliative. We have previously shown that de novo GTP synthesis is a druggable metabolic vulnerability in BM cells, through its rate-limiting enzyme, inosine monophosphate dehydrogenase (IMPDH). IMPDH inhibitors have progressed to phase-II oncology trials in the past, failing largely due to dose-limiting toxicities associated with off-target inhi...
• FcRL4 is an IgA receptor that primarily binds the joining chain AI翻译
  作者：Su, Chen; Wang, Yuxin; Zhu, Mingqi; Yang, Xiaoke; Xiao, Junyu
  作者单位：Peking University; Peking University
  摘要：Immunoglobulin A (IgA) is a crucial component of the human immune system, and its interaction with receptors is essential for immune regulation. Fc-receptor-like 4 (FcRL4) is an IgA receptor that selectively binds systemic IgA containing the joining chain (J-chain). The molecular mechanism of this interaction has remained unclear. Here, we present a cryo-EM structure of FcRL4 complexed with the dIgA core (Fc alpha dimer and J-chain), revealing a 1:1 binding stoichiometry. FcRL4 primarily inter...