25期

最新文章

• Structural and cellular insights into DCTPP1 antagonists and their synergistic action with DNMT inhibitors AI翻译
  作者：Hauk, Glenn; Liu, Jianyong; Nelson, William G.; Yegnasubramanian, Srinivasan; Berger, James M.
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine
  摘要：DCTPP1 is a nucleotide pyrophosphatase that helps preserve genomic stability and epigenetic programming by hydrolyzing and preventing the misincorporation of methylated base-modified deoxycytosine triphosphates into DNA. Through this role, DCTPP1 can degrade the efficacy of nucleotide analog-based DNA methyltransferase inhibitors and thus represents a compelling therapeutic target in cancer treatment. To identify prospective antagonists of DCTPP1, we conducted a high-throughput chemical screen...
• Structure of Human adenovirus 7 virus-like particles, a platform for developing nanotherapeutics and studying capsid assembly AI翻译
  作者：Madoo, Kiyano; Mazboudi, Ryan; Islam, Zubaida Marufee; Luo, Jonathan; Kuschner, Robert A.; Gottlieb, Paul; Dennehy, John J.; Abzalimov, Rinat R.; Galarza, Jose M.; Khayat, Reza
  作者单位：City University of New York (CUNY) System; City College of New York (CUNY); Boehringer Ingelheim; City University of New York (CUNY) System; Queens College NY (CUNY); City University of New York (CUNY) System; City University of New York (CUNY) System; City College of New York (CUNY); City University of New York (CUNY) System
  摘要：Adenoviridae family members routinely infect humans, exhibit significant genetic diversity, and are associated with a variety of illnesses. Types 4 and 7 frequently circulate in the United States and are major causes of respiratory disease. Infections can result in hospitalization and, in severe cases, death. Although a live wild-type-virus vaccine targeting these two types exists, its use is restricted to military personnel due to concerns about viral-shedding and potential for genetic recomb...
• Restoring the interplay between the endoplasmic reticulum and mitochondria by gene therapy improves Charcot-Marie-Tooth type 2A disease AI翻译
  作者：Tessier, Marine; Hamze, Zeinab; Bonello-Palot, Nathalie; Roeckel-Trevisiol, Nathalie; Da Silva, Nathalie; Verlet, Ilian; Broucqsault, Natacha; Bertaux, Karine; Delmont, Emilien; Attarian, Shahram; Bartoli, Marc; Delague, Valerie; Schneider, Bernard L.; Bernard-Marissal, Nathalie
  作者单位：Aix-Marseille Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille; Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille; Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille; Centre National de la Recherche Scientifique (CNRS); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
  摘要：Charcot-Marie-Tooth disease type 2A (CMT2A) is the most common axonal CMT and is associated with an early onset and severe motor neuropathy. CMT2A is mainly caused by dominant mutations in the MFN2 gene, encoding mitofusin-2, a GTPase located in the outer membrane of the mitochondria and endoplasmic reticulum (ER). Mutations in MFN2 affect mitochondrial dynamics. We previously demonstrated that mutated MFN2 further disrupts contacts between the ER and the mitochondria, leading to axonal degene...
• A vast temporal continuum for sensory processing arises from a nontopographic cellular multilevel gradient AI翻译
  作者：Wicke, Kathrin D.; Kladisios, Nikolaos; Kattler-Lackes, Kathrin; Felmy, Felix
  作者单位：University of Veterinary Medicine Hannover; Saarland University
  摘要：Classification of neurons into discrete populations aids the comprehension of neuronal function. However, such simplifications do not fully reflect the complexity and gradual nature of sensory stimuli and internal representations. Therefore, heterogeneous neuronal populations might be more adequate to process and represent neuronal function compared to discrete populations. Using patch-seq recordings, we identify a heterogeneous cell population in the auditory brainstem that forms an extensive...
• Oxytocin modulates the neurocomputational mechanisms engaged in learning rank relationships in social networks AI翻译
  作者：Liu, Jiawei; Qu, Chen; Philippe, Remi; Li, Siying; Derrington, Edmund; Dreher, Jean-Claude
  作者单位：South China Normal University; South China Normal University; South China Normal University; Universite Lyon 1; Centre National de la Recherche Scientifique (CNRS); Universite Lyon 1; Northeast Normal University - China
  摘要：Indirect evidence from preclinical and neuropharmacological studies suggests that oxytocin may attenuate social dominance relationships and modulate social memory. In humans, oxytocin may also modulate self- versus other-oriented reward learning and in-group/out-group decisions differently. Although the neural bases of learning social hierarchy by observation have been identified for linear hierarchies (a(1) < a(2) < a(n)), the brain mechanisms engaged in learning more complex rank relationshi...
• Decadal record of continental H2 reservoirs reveals potential for subsurface microbial life and natural H2 exploration (vol 123, e2603895123, 2026) AI翻译
  作者：Lollar, Barbara Sherwood; Warr, Oliver
• Triggering three-step relay mechanism over Cu-based electrocatalysts for nitrate reduction AI翻译
  作者：Guo, Minghao; Guo, Chengying; Cheng, Chuanqi; Zhang, Yuhan; Wang, Yuzhi; Zhang, Bin; Yu, Yifu
  作者单位：Tianjin University; Tianjin University; Nankai University; Haihe Laboratory of Sustainable Chemical Transformations
  摘要：Electrocatalytic nitrate reduction reaction (NO3RR) is a promising approach for pollutant appreciation. Cu-based catalysts have attracted extensive attention due to their favorable adsorption with nitrate. At present, the continuous hydrogenation is considered as a single reaction mechanism for NO3RR over Cu, in which the high energy barrier of NO3--to-NO2- conversion and insufficient active hydrogen (*H) supply lead to high onset potential and low faradaic efficiency. The three-step relay (TS...
• Actuation driven pseudocrease mechanics in multistable curved-crease origami shells AI翻译
  作者：Liu, Kevin T.; Tachi, Tomohiro; Paulino, Glaucio H.
  作者单位：Princeton University; University of Tokyo; Princeton University
  摘要：Shells are lightweight load-bearing structures found ubiquitously throughout nature and engineering. Reconfigurable structures can change form and function, while multistable ones enable fast, large shape changes and the ability to maintain a deformed shape without the continuous input of work. Here we present a general design method for multistable shells inspired by curved-crease origami and the differential geometry of developable surfaces. Through detailed analysis of a reference multistab...
• A high-coverage Neandertal genome from the Altai Mountains reveals population structure among Neandertals (vol 123 , e2534576123 , 2026 ) AI翻译
  作者：Massilani, Diyendo; Peyregne, Stephane; Iasi, Leonardo N. M.; de Filippo, Cesare; Mafessoni, Fabrizio; Mesa, Alba Bossoms; Sumer, Arev P.; Swiel, Yaniv; Popli, Divyaratan; Silverman, Shahar; Boyle, Michael James; Kozlikin, Maxim B.; Shunkov, Michael, V; Derevianko, Anatoly P.; Higham, Tom; Douka, Katerina; Meyer, Matthias; Zeberg, Hugo; Kelso, Janet; Paabo, Svante
• Defiance of stable lysogeny reveals hidden infection dynamics of phage Lambda AI翻译
  作者：Broux, Kevin; Backer, Leonard E.; Oome, Dries; Baert, Flo; Vandenborre, Jef; Schoeters, Seppe; Tran, Ninh Hieu Luan; Simoens, Kenneth; Waldherr, Steffen; Bernaerts, Kristel; Aertsen, Abram
  作者单位：KU Leuven; KU Leuven; University of Vienna
  摘要：Stable prophage establishment is considered a quintessential response of temperate phages when faced with host cell depletion. Scrutinizing this behavior in model phage lambda, however, revealed that many lambda-chromosomes avoid stable integration in the host chromosome, and rather assume a nonintegrated prophage-like (or p lambda) state inside the cell that keeps expressing CI-based immunity and becomes asymmetrically segregated. This creates a heterogeneous population of host cells that are...