27期

最新文章

• Evaluation of a proposed link between the SARS-CoV-2 furin cleavage site and mouse-adapted MERS-coronavirus MA30 AI翻译
  作者：Metzger, Sarah M.; Jones, Terry C.; Meier, Jenny I. J.; Richter, Anja; Klassen, Mark-Christian; Olmer, Ruth; Diegmuller, Nicolai; Heimsch, Kim C.; Drosten, Christian
  作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; University of Cambridge; Hannover Medical School; Hannover Medical School; German Center for Infection Research; Humboldt University of Berlin
  摘要：The origin of the polybasic furin cleavage site (FCS) of SARS-CoV-2 remains a central question in debates on the emergence of COVID-19. One hypothesis proposes a genetic relationship between the SARS-CoV-2 S1/S2 motif RRAR and the RRVR sequence found in the mouse-adapted MERS-CoV strain MERS-MA30. Here, we combined large-scale bioinformatic analysis with experimental virology to evaluate this scenario. Analysis of over 17 million SARS-CoV-2 genomes revealed that the S:684V substitution corresp...
• Multistep electron tunneling through tryptophans in the KatG bifunctional peroxidase monitored by a nonperturbing spin probe AI翻译
  作者：Mileo, Elisabetta; Piero, Annalisa; Lojou, Elisabeth; Cheruzel, Lionel; Gray, Harry B.; Ivancich, Anabella
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Roche Holding; Roche Holding USA; Genentech; California Institute of Technology
  摘要：The bifunctional heme peroxidase from B. pseudomallei (BpKatG) utilizes heme and three tryptophans (Trp139, Trp153, and Trp330) as unique redox cofactors in the peroxidase-like catalytic cycle, as was shown previously by multifrequency Electron Paramagnetic Resonance (EPR) spectroscopy combined with isotope labeling and site-directed mutagenesis. In this work, we exploited the redox properties of a strategically attached nitroxide as a direct probe of the long-range multistep electron-tunnelin...
• European beech reproduction is not reduced by drought, including the 2003, 2018, and 2022 extremes AI翻译
  作者：Szymkowiak, Jakub; Bogdziewicz, Michal; Kelly, Dave; Foest, Jessie; Braun, Sabine; Beudert, Burkhard; Chianucci, Francesco; Cutini, Andrea; Gaulton, Rachel; Gratzer, Georg; Kolbl, Angelika; Kunstler, Georges; Lageard, Jonathan G. A.; Meesenburg, Henning; Mezzavilla, Francesco; Mund, Martina; Nussbaumer, Anita; Pesendorfer, Mario B.; Schmidt, Wolfgang; Thimonier, Anne; Thomas, Peter A.; Vacek, Stanislav; Vacek, Zdenek; Verstraeten, Arne; Wagner, Markus; Hacket-Pain, Andrew
  作者单位：Adam Mickiewicz University; Adam Mickiewicz University; University of Canterbury; Food & Environment Research Agency; BOKU University; INRAE; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Manchester Metropolitan University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; University of Gottingen; Keele University; University of Liverpool
  摘要：Climate change is intensifying drought stress in temperate forests, but its effects on tree reproduction, central to forest regeneration and migration capability, remain poorly understood. Here, we analyze 221 time series of beech (Fagus sylvatica) seed production across Europe to test whether drought reduces seed output. We isolate drought exposure during the flowering, pollination, and seed maturation phases of reproduction, and test for legacy effects on future reproduction. Seed production...
• CPKs are involved in Ca2+ signaling encoding by enhancing OST1-initiated Ca2+ influx for ABA-induced stomatal closure in Arabidopsis AI翻译
  作者：Tan, Yan-Qiu; Ren, Ying-Yue; Yang, Yang; Wang, Jianping; Yu, Bo; Wang, Xinyong; Zhang, Peng; Zhao, Yang; Wang, Pengcheng; Wang, Yong-Fei
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Southern University of Science & Technology
  摘要：Both Ca2+-independent kinase OPEN STOMATA 1 (OST1) and Ca2+-DEPENDENT PROTEIN KINASEs (CPKs) play important roles in ABA-induced stomatal closure. We recently reported that OST1-mediated phosphorylation and activation of Ca2+ channels constituted mainly with CYCLIC NUCLEOTIDE-GATED CHANNEL 5 (CNGC5), 6, 9, and 12 (CNGC5/6/9/12) are required for ABA-induced stomatal closure in Arabidopsis. However, Ca2+-dependent protein kinases and underlying mechanisms that are involved in this Ca2+ signaling...
• Debt as a blessing: A capital screening mechanism AI翻译
  作者：Dong, Feng; Sargent, Thomas J.; Wang, Pengfei; Wang, Yizhen
  作者单位：Tsinghua University; New York University; Peking University; Peking University Shenzhen Graduate School (PKU Shenzhen); Central University of Finance & Economics
  摘要：We challenge a recently popular view that a negative interest-growth rate gap (r < g) offers a free lunch for debt-financed government spending by formulating a model in which r and g are endogenous variables shaped by fiscal policy through its effects on equilibrium multiplicity and capital allocation. Observing r < g can signal that sustained government deficits have generated multiple steady states, and the economy has converged to a stable low-efficiency equilibrium. With its heterogeneous...
• Evolution of quantitative traits with background selection AI翻译
  作者：Johri, Parul; Schraiber, Joshua G.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of Southern California; Cornell University
• Sensitivity suppression during attention shifts AI翻译
  作者：Zhang, Zixiao; He, Sheng; Zhang, Jiedong
  作者单位：Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：The brain possesses the remarkable ability to suppress undesirable signals generated by our own actions to ensure accurate perception, like the suppression of retinal motion signals during rapid eye movements, known as saccadic suppression. Attention, often referred to as the mind's eye, undergoes rapid and frequent shifts, often occurring in the absence of explicit motor actions. Is visual processing similarly suppressed during attention shifts? In this study, we employed pupillometry and mag...
• TMED9 drives non-small-cell lung cancer progression via promotion of autophagy by recruiting USP5 to deubiquitinate ATG9A AI翻译
  作者：Liu, Na; Han, Guohu; Zhang, Fusheng; Gu, Qianhui; Liu, Yuanyuan; Jia, Jing; Zhu, Xiaoren; Chen, Minbin
  作者单位：Jiangsu University; Yangzhou University; Peking University
  摘要：Non-small-cell lung cancer (NSCLC), the predominant type of lung cancer, is characterized by high invasiveness and significant mortality. Despite its clinical impact, the molecular mechanisms driving its pathogenesis and progression remain poorly understood. This study demonstrates that TMED9 is overexpressed in NSCLC and showed using multiple independent sample sets that its expression level is significantly associated with poor patient prognosis. Gain- and loss-of-function experiments reveal...
• A reset clock cannot keep time: Thermal overprinting obscures Great Unconformity origins in North China AI翻译
  作者：McDannell, Kalin T.; Gallagher, Kerry; Guenthner, William R.; Keller, C. Brenhin; Shuster, David L.
  作者单位：Dartmouth College; Universite de Rennes; University of Illinois System; University of Illinois Urbana-Champaign; University of California System; University of California Berkeley
• Initial organization and progressive expansion of the math-responsive brain network during the first school years AI翻译
  作者：Morfoisse, Theo; Becuwe, Severine; Palu, Marie; Potier-Watkins, Cassandra; Dehaene-Lambertz, Ghislaine; Dehaene, Stanislas
  作者单位：Universite PSL; College de France; CEA; Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：The neural mechanisms by which the developing brain acquires higher mathematical concepts from elementary intuitions remain poorly understood. Through a large-scale longitudinal functional MRI study of children from preschool through first and second grade, we tracked how neural responses to mathematical and nonmathematical statements change in the first 2 y of formal schooling, and we used these data to evaluate several theories of developmental change. Before school, when listening to math s...