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作者：Jose, Anex; Braun, Augustin; Hong, Sangjin; Gennis, Robert B.; Solomon, Edward I.
作者单位：Stanford University; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Heme-copper oxidases, the terminal respiratory complex in the electron transport chain, harness the energy from the reduction of dioxygen to water to pump protons across mitochondrial or bacterial membranes against a gradient to power ATP synthesis. While proton pumping in heme-copper oxidases was discovered more than four decades ago, a molecular-level understanding of the proton pumping mechanism remains elusive. Particularly, the role of the heme-copper active site, including a unique tyros...
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作者：Li, Shupeng; Rogers, John A.; Huang, Yonggang
作者单位：Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine
摘要：Stable mounting is a central requirement for skin-interfaced wearable biomedical devices, because accurate and long-term measurements with clinical utility typically demand intimate contact with the skin, whereas practical use also requires gentle removal to minimize skin irritation and damage. Existing mounting strategies often struggle to satisfy these competing requirements simultaneously, especially under prolonged wear or in the presence of sweat and moisture. Suction-based mounting has r...
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作者：Metzger, Daniel
作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg
摘要：The scientific world has lost one of its great architects with the passing of Pierre Chambon, a visionary French scientist, institution builder, and demanding yet inspiring mentor. He provided major insights into the fundamental mechanisms governing gene expression and hormonal regulation that transformed modern biology and medicine. In addition, he developed groundbreaking mouse genetic techniques, and established Strasbourg as a leading European center for life sciences research. His death o...
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作者：Rizzieri, Yana C.; Limpanasittichai, Ponpipat; Hernandez, Fernando; Mendez-Reneau, Jonas I.; Holt Jr, Stacy D.; Sutherland, Brittany; Mandakova, Terezie; Beck, James B.; Kuo, Li-Yaung; Kooyers, Nicholas J.; Li, Fay-Wei; Sigel, Erin M.
作者单位：Cornell University; Boyce Thompson Institute for Plant Research; Cornell University; National Tsing Hua University; University of Louisiana Lafayette; Missouri Botanical Gardens; George Mason University; Masaryk University; Wichita State University; Duke University; University System Of New Hampshire; University of New Hampshire
摘要：Ferns are well known for their exceptionally large genomes and high chromosome numbers, which may be in part due to whole genome duplications (WGDs) followed by slow diploidization. To better understand the mode of fern genome evolution, we focus on the heterosporous fern genus Salvinia, which exhibits striking variation in genome size and chromosome number. We generated chromosome-level genome assemblies for Salvinia cucullata, the fern with the smallest genome, and Salvinia molesta, a global...
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作者：Sheng, Huiyu; St. Leger, Raymond J.
作者单位：University System of Maryland; University of Maryland College Park
摘要：Fungi frequently transition between pathogenic, endophytic, and saprophytic lifestyles, yet the functional traits enabling these ecological shifts remain unclear. Comparative analyses of early and recently diverged lineages of Metarhizium robertsii reveal contrasting life-history strategies. Early diverged strains exhibit limited plant root association, slower insect lethality, extensive within-host proliferation, and high sporulation, whereas recently diverged strains display rapid germinatio...
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作者：Jarman, Owen D.; Bohra, Nitin; Claus, Peter; Paczia, Nicole; Erb, Tobias J.
作者单位：Max Planck Society; Max Planck Society; Philipps University Marburg
摘要：Energy-conserving mechanisms are essential in supporting cellular life. Yet in synthetic biology, it remains a challenge to reconstruct such processes from the bottom-up and integrate them with other biological functions to create complex systems with life-like properties. Recent efforts to build higher-order cell-free metabolic networks have suffered from the fact that their central oxidation reactions are not coupled to energy conservation, causing kinetic and thermodynamic limitations. Here...
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作者：Wu, Jheng-Syong; Lin, Yu-Chun; Wei, Yi-Yu; Lin, Hsin-Hung; Liu, Yang-Chih; Chang, Jen-Wei; Tu, I-Ping; Chen, Hung-Ta; Chang, Wei-Hau
作者单位：Academia Sinica - Taiwan; Academia Sinica - Taiwan; Academia Sinica - Taiwan; Academia Sinica - Taiwan; Academia Sinica - Taiwan
摘要：RNA polymerase III (Pol III) is specialized for the high-throughput synthesis of short RNAs, a capability linked to its unique TFIIE- and TFIIF-like subcomplexes that are stably associated through different stages of transcription. To date, the role of a winged helix domain (WH2) of Rpc34 subunit in the TFIIE-like subcomplex during elongation has remained a conundrum because its density is consistently absent in cryo-EM structures of Pol III elongation complexes (ECs), suggesting its high conf...
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作者：Zhao, Congfan; Yuan, Shu; You, Jiabin; Bai, Chenyun; Su, Yongjian; Cheng, Xiaojing; Shen, Shuiyun; Yan, Xiaohui; Zhang, Junliang
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University
摘要：In the oxygen evolution reaction (OER), adherent gas bubbles are conventionally viewed as a major impediment that blocks ion and mass transport by covering active sites. Here, we show that for ionomer-based electrodes, this prevailing view is oversimplified. Using a self-developed transparent on-chip electrolyzer that integrates multimodal in-situ characterization, including optical microscopy, spectroscopic analysis, and atomic force microscopy, we uncover complex intrabubble dynamics on iono...
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作者：Dawel, Amy; George, Tanya; Mah, Eric Y.; Dunn, James D.; Sutherland, Clare A. M.; Argument, Nick; Tanaka, James W.
作者单位：Australian National University; University of Victoria; University of New South Wales Sydney; University of Aberdeen; University of Western Australia
摘要：As AI-generated faces become indistinguishable from real ones, deepfake technology poses escalating threats to information integrity and security. While algorithms can detect deepfakes, they suffer from opacity and critical vulnerabilities-and training humans to identify specific visual artifacts has proven largely ineffective. Here, we introduce a fundamentally different approach that harnesses people's global impressions of faces. Building on findings that AI and human faces evoke systematic...
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作者：Deng, Wenning; Garg, Ketika; Mobbs, Dean
作者单位：California Institute of Technology; California Institute of Technology
摘要：From hunting to financial planning, many decisions are made under risk and alongside social partners whose decisions and outcomes are coupled with our own. Joint decision-making can create challenges, such as navigating conflicting risk preferences, evaluating each other's actions, and deciding whether to compromise. Yet when and why people compromise, how they evaluate each other's responsibilities during joint decision-making, and the computational and psychological underpinnings of these pr...
