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作者：Pan, Yuxiang; Li, Huijuan; Liao, Mingchun; Wang, Tianyun; Rao, Xiaoli; Wang, Qiu; Hu, Ping; Zheng, Dandan; Jiao, Yang; Chen, Luonan; Shi, Yun Stone; Zhao, Yonghua; Zhang, Xu; Li, Zhuo; Bao, Lan; Wu, Lingqian; Wang, Bin
作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; University of Chinese Academy of Sciences, CAS; Central South University; University of Macau; Peking University; Peking University; Nanjing Medical University
摘要：Intellectual disability (ID) is a highly prevalent condition affecting approximately 200 millions of people worldwide, characterized by impaired cognitive function. Dynactin complex consists of multiple protein subunits and is required for intracellular trafficking and synaptic homeostasis in developing and mature neurons. Here, we identify deleterious variants of dynactin subunit 4 (DCTN4) in ID pedigrees. DCTN4 ablation in mice results in altered neuronal positioning and apoptosis in neural ...
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作者：Deng, Hailin; Zhao, Qingkun; Liu, Taishan; Zhang, Zhenghao; Zhu, Zelin; Zhou, Yanqi; Peng, Hua-Xin; Yang, Wei; Gao, Huajian; Zhou, Haofei
作者单位：Zhejiang University; Zhejiang University; Tsinghua University
摘要：Architected materials derive functionality from geometry, yet conventional unit cell-based design limits functional heterogeneity, geometric adaptability, and robustness to defects. Inspired by natural morphogenesis, we introduce RDGenCAD, a morphogenetic design framework that translates programmable growth rules into reaction-diffusion dynamics to generate self-organized, CAD-ready architectures. A database of 120,000 morphogenetic structures reveals statistically deterministic and continuous...
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作者：Fu, Wenbo; Qiao, Pu; Bai, Henghui; Shi, Kaiyuan; Dong, Xingbang; Zhang, Jiaqing; Du, Zhaoxu; Kong, Jun; Yang, Haotian; Zhang, Xin; Zhang, Ke; Su, Lei; Nishinari, Katsuyoshi; Mao, Ho-Kwang
作者单位：Hubei University of Technology
摘要：Hydrogels have been widely used in biomedical and environmental applications, yet precise control of mechanical properties (quantified by elastic modulus, G ') over a broad range remains essential for expanding their functionality. While pressure treatment typically enhances hydrogel strength through pressure-induced crosslinking, we report a counterintuitive phenomenon in locust bean gum (LBG) hydrogels: High-pressure processing induces softening rather than stiffening. Under repeated compres...
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作者：Lima, Henrique S.; Pereira, Rodrigo M.; Moriconi, Luca; Sreenivasan, Katepalli R.; Tsallis, Constantino
作者单位：Universidade Federal Fluminense; Universidade Federal do Rio de Janeiro; New York University; New York University; The Santa Fe Institute; University of Catania
摘要：Recent investigations of turbulent circulation fluctuations have uncovered substantial insights into the statistical organization of flow structures and revealed unexpected geometric features of turbulent intermittency. Of particular interest here is the observation that circulation probability distribution functions admit a superstatistical representation, namely a description based on ensembles of BoltzmannGibbs ensembles. A fundamental phenomenological ingredient of this approach, which ser...
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作者：Liu, Guoqing; Bai, Jimin; Baggioli, Matteo; Zhang, Jie
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University
摘要：A spacetime crystal is a phase of matter that spontaneously develops periodic order in both space and time. Spacetime crystals have been experimentally observed in microscopic quantum many-body systems and, very recently, in a mesoscopic nematic liquid crystal. However, the melting process of a spacetime crystal and its underlying physical mechanisms have not yet been experimentally reported. Here, we present a direct observation of a classical continuous spacetime crystal melting in a table-t...
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作者：Meshcherina, Daria; Chaudhuri, Soma; Bhattacharya, Joydeep
作者单位：University of Pennsylvania; Pennsylvania Medicine; Hong Kong Baptist University
摘要：Poetry condenses language into minimal forms, evoking emotion, imagery, and aesthetic judgment, yet the neural basis of such evaluations remains poorly understood. We investigated how the brain evaluates two structurally matched but thematically distinct poetic forms: nature-themed Haiku and emotion-themed Senryu. Participants read poems and rated them across five dimensions-aesthetic appeal, vivid imagery, being moved, originality, and creativity-while EEG was recorded. Using multiclass gradi...
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作者：Rouxel, Romain; Luttig, Julian; Jones, Michael R.; Zigmantas, Donatas
作者单位：Lund University; University of Ottawa; University of Bristol
摘要：Understanding the remarkable quantum efficiency of solar energy collection in phototrophic bacteria requires a clear description of the functional connectivity between the individual complexes comprising the photosynthetic apparatus. While significant progress has been made since the 1980s in understanding energy transfer dynamics within isolated complexes, information about intercomplex processes in intact cells is still sparse. One reason is the great complexity of intact systems that leads ...
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作者：Wang, Jizhou; Marshall, Nathan; Han, Zehua; Wang, Kai; Sprague, Richard; Yi, Zhenhuan; Yu, Wenxuan; Xu, Xingqi; He, Zhe; Wang, Da-Wei; Scully, Marlan O.; Sokolov, Alexei V.
作者单位：Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Zhejiang University
摘要：Vibrational microspectroscopy, including both Raman-based and infrared-based techniques, can map the chemical distribution of samples based on molecular vibrations without labeling. However, imaging fast dynamics in living organisms remains challenging. To address this, we propose a wide-field infrared microspectroscopy capable of single-shot imaging, where each image is captured with a single pair of laser pulses lasting approximately one picosecond. It minimizes motion blur and allows observ...
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作者：Alian, Akram; McCullough, John; Moss, Frank R.; Talledge, Nathaniel; Mohammed, Arshad; Gerstner, Cecilia D.; Dalluge, Jacob A.; Paine, Elliott L.; Davulcu, Omar; Chang, Chi-Lun; Frost, Adam; Sundquist, Wesley I.
作者单位：Utah System of Higher Education; University of Utah; Oregon Health & Science University; United States Department of Energy (DOE); Pacific Northwest National Laboratory; St Jude Children's Research Hospital
摘要：Different inositol phospholipids (PIPs) distribute to distinct subcellular organelles, creating an addressing system that dictates the sites of action of PIP-binding proteins, including components of the Endosomal Sorting Complexes Required for Transport (ESCRT). The ESCRT machinery is recruited to remodel many different cellular membranes through combinatorial binding interactions made by the early-acting ESCRT-I and ESCRT-II complexes with PIPs, ubiquitin modifications, and membrane-specific...
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作者：Birnbaum, Foster; Keating, Amy E.
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：Computational protein design using machine learning models has advanced rapidly since the introduction of AlphaFold2. There is now a suite of tools that enable in silico design of proteins with desired structures and properties. Most design workflows require fitting a designed backbone with a sequence that stabilizes it, and many machine learning sequence design models have been proposed. These models are trained to recover the native sequence paired with a known structure, a task known as nat...
