27期

最新文章

• Neural tissues and chondrostean traits in a Carboniferous actinopterygian AI翻译
  作者：Caron, Abigail M.; Tietjen, Kristen; Coates, Michael I.
  作者单位：University of Chicago; University of Chicago; University of Kansas; University of Kansas
  摘要：Ray-finned fishes (Actinopterygii) represent over half of extant vertebrate species, but their early evolutionary history is largely unresolved. Current phylogenetic estimates, corroborated by discoveries of preserved neural tissues, place most Palaeozoic actinopterygians outside the crown group and leave the deep roots of major extant divisions depauperate. Moreover, apparent fossil brains in early fishes are minuscule relative to endocranial chamber space, implying that endocasts are poor in...
• Optimal interventions to curb urban conflagration AI翻译
  作者：Chulahwat, Akshat; Mahmoud, Hussam
  作者单位：Vanderbilt University; Vanderbilt University
  摘要：Understanding the efficacy of wildfire mitigation policies is a clear first step toward curbing wildfire losses during an urban conflagration. In this study, we used a validated model to quantify the impact of the spatial distribution of the combined management of open-space vegetation and mitigation of the home ignition zone (HIZ) on the resulting fire boundary and damage to the built environment in the Palisades area of Los Angeles, California. Fuel management in open-space involves reducing...
• Reply to Gorski et al.: Polarization requires opinions, not just negative ties AI翻译
  作者：Thurner, Stefan; Hofer, Markus; Korbel, Jan
  作者单位：Medical University of Vienna; The Santa Fe Institute
• The mechanism for ligand activation of the Smoothened G protein-coupled receptor AI翻译
  作者：Yu, Ryan D.; Vo, Amy-Doan P.; Kim, Soo-Kyung; Goddard, William A.
  作者单位：California Institute of Technology
  摘要：The Smoothened (SMO) G protein-coupled receptor is a key part of the Hedgehog (Hh) signaling pathway, and it is an oncoprotein that is an important target for understanding cancers such as basal cell carcinoma. However, its mechanism of activation remains unknown. To this end, we investigate here the sequence of G protein and cholesterol (CHL) ligand binding to SMO on the pathway toward activation. Our results are consistent with the G protein-first activation pathway of SMO in the Hh signalin...
• Orientation-tuned surround suppression exhibits a unique laminar signature in the human primary visual cortex AI翻译
  作者：Emerson, Joseph H.; Navarro, Karen; Olman, Cheryl A.
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Spatial context modifies visual perception by enhancing novel and salient features over spatially redundant features in the underlying neural code of the primary visual cortex (V1). Although multiple intracortical pathways contribute to contextual modulation, their specific contributions to different types of contextual modulation are not fully understood. Leveraging the distinct laminar connectivity patterns of feedforward, feedback, and lateral pathways, we used ultra-high-resolution fMRI (7...
• Lhcf2 in the peripheral antenna is essential for nonphotochemical quenching and Lhcx1 accumulation in the diatom Chaetoceros gracilis AI翻译
  作者：Xing, Jian; Kumazawa, Minoru; Ifuku, Kentaro
  作者单位：Kyoto University; Hokkaido University
  摘要：Photosynthetic organisms must continuously balance efficient light harvesting with protection against excess excitation energy, a challenge met by nonphotochemical quenching (NPQ). Although the molecular components involved in NPQ have been extensively studied, how the essential energy-quenching site is assembled remains poorly understood, particularly in marine diatoms. Here, we show that in the centric diatom Chaetoceros gracilis, which belongs to one of the most abundant and diverse genera ...
• Reply to McDannell et al.: Thermal overprinting does not obscure the tectonic origin of the Great Unconformity AI翻译
  作者：Duan, Liang; Christie-Blick, Nicholas; Zattin, Massimiliano; Zhan, Rong-Ruo; Yang, Zhao; Wan, Bo; Olivetti, Valerio; Zhang, Xingliang
  作者单位：Northwest University Xi'an; Northwest University Xi'an; Columbia University; Columbia University; University of Padua; Chinese Academy of Sciences; Institute of Geology & Geophysics, CAS; Northwest University Xi'an
• Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir AI翻译
  作者：Garcia, Mauro A.; Farrell-Sherman, Anna; Aydin, Beril; Zhuo, Junlin; Fray, Emily J.; Zinsser, Anna M.; Lai, Jun; Sowers, Kirsten; Li, Haoyue; Lopez, Brianna M.; Abeyta-Lopez, Anthony; Chu, Tifany; Lubbeck, Donald; Chae, Moonki; Bachmann, Niklas; Varriale, Joseph; Westfall, Dylan H.; Hoh, Rebecca; Dalhuisen, Thomas; Simonetti, Francesco R.; Peluso, Michael J.; Deeks, Steven G.; Siliciano, Robert F.; Cohn, Lillian B.; Siliciano, Janet D.
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute
  摘要：HIV-1 cure requires preventing viral rebound after treatment interruption, but quantitative criteria defining the rebound-competent reservoir are lacking. We studied individuals undergoing observational treatment interruption without confounding interventions to identify virologic and immunologic determinants of rebound. In 9 of 13 participants, rebound viruses were genetically identical or similar to proviruses in circulating resting CD4+ T-cells. We found no evidence of recombination among r...
• Two-step mechanism of Bruton's tyrosine kinase membrane recruitment and activation AI翻译
  作者：McAllister, Rachel A.; Stiegler, Amy L.; Chari, Keerthana; Chari, Meera; Bhattacharyya, Moitrayee; Gupta, Kallol
  作者单位：Yale University; Yale University; Yale University; Yale University
  摘要：Peripheral membrane proteins (PMPs) are critical mediators of signaling cascades initiated at the cell surface. Their functions depend on their innate ability to interact dynamically with membranes in response to changing cellular conditions. This membrane recruitment may occur via high-affinity interactions with specific lipids/proteins or via transient, low-affinity interactions with the membrane. These weak and dynamic interactions, which are critical regulators of PMP function, are challen...
• The role of reduced aerosol masking from air pollutant emission reductions in recent global warming acceleration (2013-2023) (vol 123, e2534130123, 2026) AI翻译
  作者：Wang, Xiaochun; Wang, Shuxiao; Faluvegi, Gregory; Yi, Wen; Gao, Da; Li, Shengyue; Zhang, Yanning; Liu, Huan; Jo, Duseong S.; Shen, Jiewen; Gao, Yang; Wang, Yuan; Zhang, Yuqiang; Jiang, Zhe; Ke, Hong; He, Kebin; Hao, Jiming; Shindell, Drew; Zhao, Bin
  作者单位：Tsinghua University; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Goddard Institute for Space Studies; Columbia University; Tsinghua University; Seoul National University (SNU); Ocean University of China; Ocean University of China; Laoshan Laboratory; Stanford University; Shandong University; Chinese Academy of Sciences; Institute of Atmospheric Physics, CAS; Nanjing Institute of Geology & Paleontology, CAS; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Duke University