28期

最新文章

• Inhibition of elastin degradation alleviates joint degeneration in aging mice, dogs, and human models AI翻译
  作者：Yi, Junzhi; Xiao, Xiao; Zhang, Hui; Xu, Xinjie; Chen, Keyu; Cai, Xinqi; Zhu, Yutao; Mo, Xianan; Xiong, Shihan; Chen, Zhichu; Sui, Hairu; Wu, JiaChun; Xu, Jiaqi; Chen, Xuri; Wu, Yan; Yin, Zi; Cai, Youzhi; Zhang, Xianzhu; Zhou, Jing; Liu, Hua; Ouyang, Hongwei
  作者单位：Zhejiang University; Liangzhu Laboratory; Zhejiang University; Zhejiang University; Zhejiang University
  摘要：Extracellular matrix degradation is a fundamental pathological feature of osteoarthritis, while the roles of degraded matrix remain largely unknown. We previously showed that serum elastin fragments were a systemic aging driver. Here, we found that elastin fragments were upregulated in synovial fluid in dual-center osteoarthritis patients. Elastin fragments actively impaired joint tissue in mice and human explants. Mechanistically, a specific elastin motif containing Valine-Glycine-Valine-Alan...
• Dendritic morphology and synaptic nonlinearities enhance functional complexity in human cortical neurons AI翻译
  作者：Aizenbud, Ido; Yoeli, Daniela; Beniaguev, David; de Kock, Christiaan P. J.; London, Michael; Segev, Idan
  作者单位：Hebrew University of Jerusalem; Vrije Universiteit Amsterdam; Hebrew University of Jerusalem
  摘要：Humans exhibit unique cognitive abilities within the animal kingdom, but the neural mechanisms driving these advanced capabilities remain poorly understood. Human cortical neurons differ from those of other species, such as rodents, in both their morphological and physiological characteristics. Could the distinct properties of human cortical neurons help explain the superior cognitive capabilities of humans? Understanding this relationship requires a measure to quantify how neuronal properties...
• Identification and distribution of a downregulatory signaling alkyloxazole in Streptomyces AI翻译
  作者：Madden, Michael; Xue, Dan; Xu, Mingming; Holandez-Lopez, Katherine; Budiselich, Joseph; Tran, Sarah; Espinosa, Cole; Li, Jie
  作者单位：University of Texas System; University of Texas Austin; University of South Carolina System; University of South Carolina Columbia
  摘要：Streptomyces use small molecules to dictate morphological development and secondary metabolism. Most of these signaling compounds are inducers derived from gamma-butyrolactone (GBL)-synthesizing enzymes. As such, biosynthetically distinct and downregulatory signaling molecules remain understudied in Streptomyces. Here, we report the identification of alkyloxaozle (AOX, 1), a downregulator of sporulation and antibiotic production in Streptomyces. 1's structure features an oxazole head flanked b...
• Louis E. Brus (1943-2026): A consummate physical chemist and a pioneer in the exploration of spectroscopy of materials at the nanoscale AI翻译
  作者：Wilson, William L.; Harris, A. L.; Harris, T. D.; Steigerwald, M. L.; Tully, J. C.; Wong, S.
  作者单位：Harvard University; United States Department of Energy (DOE); Brookhaven National Laboratory; Columbia University; Yale University; State University of New York (SUNY) System; Stony Brook University
  摘要：Last year we lost a true pioneer in the field of nanoscience. Louis E. Brus didn't chase fame, he chased the problem. His career is a monument to the power of curiosity driven science, the kind of impactful science nurtured by Bell Laboratories in the 1980s and 1990s. Collaborative to his core, Louis is as good an example of a Bell Labs type as you can find. His intellect, mentorship, and kindness will be greatly missed by his friends, students, and colleagues.
• Physically intelligent capsule robots with embodied memory and logic in the gastrointestinal tract AI翻译
  作者：Chen, Huyue; Liu, Xurui; Ma, Jiahai; Zhao, Yishen; Yang, Chaoyu; Chan, Kai-Fung; Chiu, Philip Wai Yan; Shao, Lei; Zhang, Wenming; Zhang, Li; He, Qiguang; Sitti, Metin
  作者单位：Chinese University of Hong Kong; Koc University; Koc University; Max Planck Society; Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; Shanghai Jiao Tong University; Shanghai Jiao Tong University
  摘要：Miniaturized medical robots offer a promising solution for minimally invasive measurements and interventions in the gastrointestinal (GI) tract. Clinical assessment of GI disorders is commonly guided by threshold-based physiological indicators, including pressure, temperature, and pH, which motivate event-triggered strategies for personalized medicine. However, identifying homeostatic dysregulation and enabling in-situ therapy remains challenging, because ingestible robotic systems must tightl...
• Stress granules as RNA triage hubs suppress extracellular vesicle secretion under oxidative stress in cancer AI翻译
  作者：Dong, Yue; Yoshida, Takeshi; Maeda, Mitsuyo; Adachi, Haruki; Eguchi, Asami; Mishiro-Sato, Emi; Okuzaki, Daisuke; Kataoka, Yosky; Yoshida, Takuya; Oneyama, Chitose
  作者单位：Aichi Cancer Center; Kobe University; Nagoya City University; Nagoya University; Nagoya University
  摘要：Cancer cells confronting oxidative stress must coordinate their extracellular vesicle (EV) secretion to balance intercellular signaling with the intracellular programs required for survival, yet how these decisions are integrated remains poorly understood. Here, we identify a stress-adaptive mechanism in which stress granules (SGs) selectively suppress CD63+ EV release. Using a bioluminescent EV-reporter screen, we found that the clinical compound YM155 selectively inhibits CD63+ EV secretion ...
• The emergence of human influence on the ozone layer by the 1960s AI翻译
  作者：Guan, Jian; Santer, Benjamin D.; Wang, Peidong; Fu, Qiang; Garcia, Rolando R.; Li, Yaowei; Stone, Kane; Kinnison, Douglas E.; Zhang, Jun; Chiodo, Gabriel; Lamarque, Jean-Francois; Solomon, Susan
  作者单位：Massachusetts Institute of Technology (MIT); University of East Anglia; University of Washington; University of Washington Seattle; National Center Atmospheric Research (NCAR) - USA; Complutense University of Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UCM - Instituto de Geociencias (IGEO)
  摘要：The Antarctic ozone hole was first reported in 1985, and small ozone losses at the global scale were also observed in the late 1980s. The combination of field and laboratory measurements, together with modeling, quickly established anthropogenic chlorofluorocarbons (CFCs) as the cause of both the Antarctic and global ozone depletion. However, when, where, and why the earliest ozone depletion could have been detected has not been determined. Here, we conduct a thought experiment to investigate ...
• Diffusion-induced instabilities promote cooperation in eco-evolutionary networks AI翻译
  作者：Roy, Sourav; Anwar, Md Sayeed; Carletti, Timoteo; Perc, Matjaz; Ghosh, Dibakar
  作者单位：Ahmedabad University; Indian Institute of Science Education & Research (IISER) - Kolkata; University of Namur; University of Maribor; Kyung Hee University; Korea University; Indian Statistical Institute; Indian Statistical Institute Kolkata
  摘要：Understanding how cooperation persists despite the advantage of selfish behavior remains a central challenge in evolutionary dynamics. Classical models of public goods dilemmas predict dominance of defectors, yet natural and social systems often sustain cooperation. We study an eco-evolutionary public goods game on complex networks where cooperators and defectors diffuse at different rates. When the isolated system is in a defector-dominated coexistence regime, faster dispersal of defectors th...
• Mathematical misdefinition of adjusted cloud-fraction change limits isolation of aerosol effects AI翻译
  作者：Song, Zhe; Cen, Zhengnan; Chen, Lang; Zhang, Jie; Xi, Huan; Yao, Ningning; Li, Xiang; Yu, Shaocai
  作者单位：Zhejiang Gongshang University; Zhejiang Gongshang University; Zhejiang University; Fudan University; Zhejiang Gongshang University
• Reply to Huang and Dong: Clarifying the interpretation of rapid steroid effects in social recognition AI翻译
  作者：Aspesi, Dario; Varatharajah, Anjana; Cioffi, Lucia; Diviccaro, Silvia; Caruso, Donatella; Becke, Natalina; Lalonde, Jasmin; Perreault, Melissa L.; Melcangi, Roberto C.; MacLusky, Neil J.; Choleris, Elena
  作者单位：University of Guelph; University of Guelph; University of Milan; University of Guelph; University of Guelph