Dendritic morphology and synaptic nonlinearities enhance functional complexity in human cortical neurons

• 成果类型: Article
• 署名作者: Aizenbud, Ido; Yoeli, Daniela; Beniaguev, David; de Kock, Christiaan P. J.; London, Michael; Segev, Idan
• 署名单位: Hebrew University of Jerusalem; Vrije Universiteit Amsterdam; Hebrew University of Jerusalem
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2533168123
• 发表日期: 2026-07-14
• 页码: e2533168123
• 关键词: single neuron computation; dendritic computation; functional complexity; human neurons; cortical pyramidal neurons; pyramidal neurons; DISCRIMINATION; computations; potentials; plasticity; expansion; spikes; cortex

摘要

Humans exhibit unique cognitive abilities within the animal kingdom, but the neural mechanisms driving these advanced capabilities remain poorly understood. Human cortical neurons differ from those of other species, such as rodents, in both their morphological and physiological characteristics. Could the distinct properties of human cortical neurons help explain the superior cognitive capabilities of humans? Understanding this relationship requires a measure to quantify how neuronal properties contribute to the functional complexity of single neurons; yet, such a standardized measure is currently missing. Here, we propose the Functional Complexity Index (FCI), a general, deep-learning-based framework for assessing the input-output complexity of neurons. By comparing the FCI of cortical pyramidal neurons across layers in rats and humans, we identified key morpho-electrical factors that underlie neuronal functional complexity. Human cortical pyramidal neurons are significantly more functionally complex than their rat counterparts, primarily due to differences in dendritic membrane area and branching patterns, as well as in the density and nonlinearity of NMDA-mediated synaptic receptors. These findings reveal the structural and biophysical basis for the enhanced functional properties of human cortical neurons, providing a key step toward understanding the underpinnings of our enhanced cognitive capabilities.