28期

最新文章

• Mesoscale developmental rivalry in the human extrastriate visual cortex AI翻译
  作者：Nasr, Shahin; Skerswetat, Jan; Kennedy, Bryan; Schmidt, Marianna E.; Gaier, Eric D.; Morland, Antony B.; Bex, Peter; Hunter, David G.
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Northeastern University; University of California System; University of California Irvine; Max Planck Society; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); University of York - UK; University of York - UK
  摘要：The human extrastriate visual cortex contains fine-scale columns selectively responsive to motion, disparity, and color. However, the developmental interplay between these functional modules remains poorly understood. Using high-resolution functional MRI, we compared the mesoscale organization of the extrastriate cortex in 16 individuals with normal vision and 15 participants with amblyopia (PwA) caused by strabismus (n = 8) or anisometropia (n = 7). In controls, the cortical territory occupie...
• QnAs with Daniel Herschlag AI翻译
  作者：Ravindran, Sandeep
• Sex- and experience-dependent regulation of synaptic protein turnover AI翻译
  作者：Heo, Seok; Zhang, Shiyu; Mun, Dong-Gi; Pandey, Akhilesh; Bygrave, Alexei M.; Huganir, Richard L.
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; Tufts University; Mayo Clinic; Mayo Clinic
  摘要：Synaptic transmission can be tuned through plasticity mechanisms that regulate synaptic strength, structure, and number. In vivo measurements demonstrate remarkable spine dynamics, with subsets of synapses persisting for months. This correlates with the longevity of certain memories, which can persist for an organism's lifetime. The molecular basis supporting the long-term stability of specific synapses and the long-term durability of memories remains unknown. At the protein level, most protei...
• Dolphins use names to remember whom to avoid AI翻译
  作者：Sayigh, Laela
  作者单位：Woods Hole Oceanographic Institution
• The role of nonfinancial factors in the Congressional Budget Office's health insurance coverage projections AI翻译
  作者：Hong, Nianyi; Hopkins, Ben
  摘要：Nonfinancial factors play an important role in people's coverage decisions as premiums, cost sharing, and other factors that determine the financial value of health insurance cannot fully explain patterns in take-up rates. The Congressional Budget Office (CBO) is tasked with estimating the budgetary and coverage effects of policy and economic changes that affect health insurance markets, which includes considering the interactions between nonfinancial factors and policy design. The agency grou...
• Controlled generation of 3D vortices in driven atomic Josephson junctions AI翻译
  作者：Singh, Vijay Pal; Mathey, Ludwig; Ott, Herwig; Amico, Luigi
  作者单位：Technology Innovation Institute; University of Hamburg; University of Hamburg; University of Hamburg; RPTU University Kaiserslautern
  摘要：We propose an ac-driven atomic Josephson junction as a clean and tunable source of three-dimensional (3D) solitary waves in quantum fluids. Depending on the height of the junction barrier, the emitted excitations appear as vortex rings at low velocity or vorticity-free rarefaction pulses near the sound velocity, thus spanning the complete Jones-Roberts family of solitons. The Shapiro-step phenomenon renders the emission deterministic: on the first, second, third Shapiro steps, the junction eje...
• Educational expansion and the hidden reversal of the Flynn effect-Differential trends across socioeconomic strata AI翻译
  作者：Bratsberg, Bernt; Fjell, Anders M.; Rogeberg, Ole J.; Walhovd, Kristine B.
  作者单位：Norwegian Institute of Public Health (NIPH); University of Oslo; University of Oslo
  摘要：In recent decades, the United States and several European countries have seen a plateau and reversal of the population-level gains in cognitive test scores that accumulated over the 20th century-the Flynn effect. We examined whether the Flynn effect and its reversal-declining mean scores across cohorts-differ by socioeconomic status, and whether changes in education can account for this. Using compulsory military conscription cognitive tests linked to administrative records with near-complete ...
• Intracellular structural modifications of natural peptidoglycan fragments preceding NOD2 signaling in mammalian cells AI翻译
  作者：Feng, Shiliu; Adamson, Christopher; Li, Chenyu; Ng, Evan Wei Long; Qiao, Yuan
  作者单位：Nanyang Technological University
  摘要：Bacterial peptidoglycan fragments (PGNs) are pathogen-associated molecular patterns that activate the mammalian innate immune system, particularly through NOD2 signaling pathways. Since NOD2 is a cytosolic sensor in mammalian cells, cellular assays are commonly used to identify bioactive PGNs that elicit NOD2 response, with muramyl dipeptide (MDP) long recognized as the minimal NOD2 agonist. However, recent studies have highlighted the intracellular phosphorylation of MDP by mammalian N-acetyl...
• HIV-1 capsid interactions with Nuclear Pore Complex components support nuclear entry via affinity gradient AI翻译
  作者：Melcak, Ivo; Slack, Ryan L.; Lorson, Zachary C.; Emanuelli Castaner, Andres; Ambrus, Krisztina; Winkjer, Jonathan S.; Kirby, Karen A.; Dick, Robert A.; Sarafianos, Stefan G.
  作者单位：Emory University
  摘要：Before entering the nucleus, the HIV capsid core [composed of capsid (CA) proteins] must translocate through the Nuclear Pore Complex (NPC). This process relies on direct interactions between CA and the phenylalanine-glycine (FG) repeats in nucleoporins (NUPs) within the NPC. FG repeats are generally classified into three canonical motifs: FG, GLFG, and FxFG, which are differentially distributed along the NPC axis: FG and FxFG motifs are predominantly at the cytoplasmic periphery and in the nu...
• Science in service: Behavioral research applications across federal agencies AI翻译
  作者：Chin, Alycia; Fischhoff, Baruch
  作者单位：U.S. Securities & Exchange Commission (SEC); Carnegie Mellon University; Carnegie Mellon University