28期

最新文章

• Turning policy implications into policy impact: Lessons from behavioral science in financial markets AI翻译
  作者：Chin, Alycia; Carman, Katherine G.; Craig, Adam W.; Cook, Jonathan A.; Zimmerman, David B.
  作者单位：U.S. Securities & Exchange Commission (SEC); University of Kentucky
  摘要：We describe how research can inform policymaking. We begin by summarizing the policy formation process, offering a framework illustrating how interactions between scientists and policymakers can provide mutual benefits. We then describe four research initiatives from the Securities and Exchange Commission's Office of Investor Research (OIR) as examples of how behavioral sciences can help inform policymakers. The first initiative established a probability-based nationally representative survey ...
• Covalent phytobilin adducts of GUN4 implicate a photoprotective mechanism in chlorophyll biosynthesis AI翻译
  作者：Wang, Yan; Hou, Chunhui; Rockwell, Nathan C.; Brzezowski, Pawel; Zhang, Weiqing; Huang, Xiahe; Fan, Qiuling; Wang, Yingchun; Grimm, Bernhard; Lagarias, J. Clark; Duanmu, Deqiang
  作者单位：Huazhong Agricultural University; Hubei Hongshan Laboratory; University of California System; University of California Davis; Polish Academy of Sciences; Franciszek Gorski Institute of Plant Physiology Polish Academy of Sciences; Humboldt University of Berlin; Chongqing University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Agricultural Sciences; Guangdong Laboratory for Lingnan Modern Agriculture; Agriculture Genomes Institute at Shenzhen, CAAS
  摘要：In the green alga Chlamydomonas reinhardtii, loss of chlorophyll synthesis under light stress is associated with degradation of the porphyrin-binding H-subunit (CHLH1) of magnesium chelatase (MgCh). This degradation is exacerbated by the absence of GENOMES UNCOUPLED 4 protein (GUN4) or its phycocyanobilin (PCB) ligand. PCB is synthesized from heme via the action of heme oxygenase HMOX1 followed by a ferredoxin-dependent bilin reductase (FDBR), a ubiquitous enzyme family in oxyphototrophs. We s...
• Domesticated, not feral: Why evolvable AI is not yet a Darwinian threat AI翻译
  作者：Boudry, Maarten
• Vimentin promotes actin assembly by stabilizing ATP-actin subunits at the barbed end AI翻译
  作者：Paty, Lilian; Kalvoda, Lukas; Varela-Salgado, Maritzaida; Tran, Quang D.; Lenz, Martin; Jegou, Antoine; Romet-Lemonne, Guillaume; Leduc, Cecile
  作者单位：Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI)
  摘要：Vimentin intermediate filaments play essential roles in maintaining cell integrity and regulating numerous cellular functions. In particular, vimentin cooperates with the actin cytoskeleton in key cellular processes that rely on actin dynamics, such as migration, division, and mechanosensing. While there is evidence that these two cytoskeletal components interact in cells, the underlying molecular mechanisms are only partially understood. Actin and vimentin can interact through biochemical sig...
• Structural basis of complement anaphylatoxin receptor activation by an immunostimulant lead candidate AI翻译
  作者：Dalal, Annu; Yadav, Manish K.; Ganguly, Manisankar; Mishra, Sudha; Yadav, Ravi; Sinha, Shachie; Roy, Nabarun; Tiwari, Divyanshu; Mukherjee, Debdatta; Reyaz, Ashna; Dsouza, Calvin A.; Nigam, Ameesha; Banerjee, Nilanjana; Li, Xaria X.; Clark, Richard J.; Woodruff, Trent M.; Banerjee, Ramanuj; Gati, Cornelius; Shukla, Arun K.
  作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur; University of Queensland
  摘要：Activation of the complement cascade is a primary innate immune response mechanism to combat pathogenic infections. Complement anaphylatoxins (i.e., C3a and C5a) exert a robust inflammatory response via prototypical GPCRs (i.e., C3aR and C5aR1). Several peptides derived from anaphylatoxins have shown promise as immunostimulants from therapeutic standpoint by eliciting immune response without excessive inflammation. EP67, a C5a-derived decapeptide, is the most advanced candidate with preclinica...
• Circadian screening of neutrophils identifies therapeutic targets in multiple sclerosis AI翻译
  作者：De Virgiliis, Francesco; Barnoud, Coline; He, Wenyan; Zeng, Qun; Pick, Robert; Sun, Tianyue; Jemelin, Stephane; Oliva, Valeria Maria; Furlan, Tiphaine; Picon-Munoz, Carmen; Merkler, Doron; Scheiermann, Christoph
  作者单位：University of Geneva; University of Geneva; University of Geneva; University of Munich
  摘要：Circadian rhythms are intrinsic time-keeping mechanisms that play a critical role in tuning immunity. Here, we investigated the impact of circadian rhythms on the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis (MS). We demonstrate that circulating neutrophils in blood significantly increase early in EAE, prior to symptoms onset. Importantly, we found that these cells infiltrate the central nervous system (CNS) in a time-of-day (ToD)-depend...
• Spatial transcriptomic mapping of postnatal mouse uterine development AI翻译
  作者：Jamaluddin, M. Fairuz B.; Syed, Shafiq M.; Mohammed, Riazuddin; Goad, Jyoti; Hasan, Mehedi; Kumar, Manish; Moore, Isabella; Nagendra, Prathima B.; Vallabani, Naga Veera Srikanth; Bartlett, Florence; Anthonydhason, Vimala; Tanwar, Pradeep S.
  作者单位：University of Newcastle; University of California System; University of California San Francisco; Johns Hopkins University; Johns Hopkins Medicine; University of London; Queen Mary University London
  摘要：Postnatal uterine development requires precise coordination of epithelial differentiation, gland formation, and stromal organization, yet how transcriptional programs are spatially integrated during this process remains poorly understood. Here, we generated a spatially resolved transcriptomic map of the mouse uterus across key postnatal stages from day 3 to day 21 by combining high resolution in situ transcriptomics with histology, proteomics, genetic models, and functional assays. This approa...
• Fracture-driven weakening amplifies projected ice loss from West Antarctica AI翻译
  作者：Blasco, Javier; Coulon, Violaine; Izeboud, Maaike; Gregov, Thomas; Li, Yanjun; Pattyn, Frank
  作者单位：Universite Libre de Bruxelles; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; Vrije Universiteit Brussel; University of Lausanne; Sun Yat Sen University; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Zhuhai)
  摘要：Ice shelves buttress the flow of the Antarctic ice sheet, but this stabilizing effect weakens as fractures form, reducing ice viscosity and accelerating ice discharge toward the ocean. Here, we incorporate physically consistent damage mechanics into an ice-sheet model and apply it across the Amundsen Sea Embayment, the largest current contributor to Antarctic mass loss. Simulations reproduce key satellite-derived damage patterns under present-day conditions. Projections to 2300 show that allow...
• Reply to Boudry: The threat of evolvable AI is too grave to be left to intuition AI翻译
  作者：Muller, Viktor; Steels, Luc; Szathmary, Eors
  作者单位：Eotvos Lorand University; Eotvos Lorand University
• Endothelial Arf6 sustains electrical signaling and cerebral blood flow in mice through PIP2-dependent activation of Kir2.1 channels AI翻译
  作者：Noterman-Soulinthavong, Maria F.; Sancho, Maria; de la Cruz, Saul Huerta; Yarboro, Michael; Mandala, Maurizio; Koide, Masayo; Beaufort, Nathalie; Todorov-Volgyi, Katalin; Moreland, Emma; Hill-Eubanks, David; Dichgans, Martin; Nelson, Mark T.
  作者单位：University of Vermont; University of Calabria; University of Munich; University of Munich; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); University of Manchester
  摘要：Brain capillaries sense neural activity and direct blood flow to active regions-a process termed neurovascular coupling that underlies activity-dependent increases in local perfusion (functional hyperemia). A key contributor to functional hyperemic responses is the capillary endothelial cell (cEC) inward rectifier K+ (Kir2.1) channel, which, when activated by neuronal activity-derived extracellular K+, initiates vasodilatory electrical signals that propagate through the vascular network. Kir2....