28期

最新文章

• High-resolution structure of monomorphic Aβ1-40 fibrils AI翻译
  作者：Bahri, Salima; Palani, Ravi Shankar; Silvers, Robert; Michael, Brian; Lattanzi, Veronica; Andre, Ingemar; Linse, Sara; Griffin, Robert G.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); State University System of Florida; Florida State University; Lund University
  摘要：Amyloid-beta (A beta) fibrils primarily composed of A beta 1-40 and A beta 1-42 form the core of senile plaques in Alzheimer's disease. A beta 1-40 fibrils may exhibit significant polymorphism influenced by sample preparation conditions, complicating atomic resolution structural characterization. To establish a reliable structural baseline, we developed a protocol for expressing and purifying recombinant A beta 1-40 that forms monomorphic fibrils under physiological conditions (pH 7.4). We pre...
• Mechanistic links between coexistence, productivity, and stability in experimental grasslands (vol 123, e2602893123, 2026) AI翻译
  作者：Hong, Pubin; Schmid, Bernhard; Craven, Dylan; Liang, Maowei; Luo, Mingyu; Wang, Zeyu; Yang, Chen; Zhou, Libin; Allan, Eric; Catford, Jane A.; Eisenhauer, Nico; Feng, Yanhao; Hautier, Yann; Huang, Mengjiao; Huang, Yuanyuan; Isbell, Forest; Jiang, Lin; Loreau, Michel; Reich, Peter B.; Roscher, Christiane; van Ruijven, Jasper; Tilman, David; Weigelt, Alexandra; Wang, Shaopeng
  作者单位：Peking University; Universidad Mayor; Lanzhou University; Chinese Academy of Sciences; Nanjing Institute of Geography & Limnology, CAS; University of Bern; University of Bern; University of London; King's College London; Australian National University; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Leipzig University; Utrecht University; Basque Centre for Climate Change (BC3); University of Minnesota System; University of Minnesota Twin Cities; University System of Georgia; Georgia Institute of Technology; Centre National de la Recherche Scientifique (CNRS); University of Minnesota System; University of Minnesota Twin Cities; University of Michigan System; University of Michigan; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Wageningen University & Research; University of California System; University of California Santa Barbara
• User interaction with digital platforms: A consumer protection perspective AI翻译
  作者：Lew, Nellie; Raval, Devesh R.
  摘要：The rapid growth of digital platforms has transformed how consumers interact with the marketplace and led to new challenges for consumer protection. This Perspective describes how the Federal Trade Commission's Bureau of Economics uses behavioral insights and empirical methods to support efforts to prevent unfair or deceptive business practices in digital markets. We highlight two studies that address critical knowledge gaps in digital consumer protection, including how consumers perceive and ...
• Magnetically actuated microrobotic system for sequential treatment of biofilm AI翻译
  作者：Li, Shunyao; Mei, Yu; Xu, Kai; Sheng, Huaixuan; Chen, Yu-an; Teng, Mingda; Xu, Bohan; Jiang, Bingqian; Yu, Chengxuan; Li, Huizhu; Zhao, Shiyun; Wang, Yi; Zhang, Xiao; Zhao, Yiyang; Wang, Yueming; Wo, Yan; Li, Zhaochen; Shen, Siwen; Li, Yunxia; Tang, Min; Mei, Yongfeng; Chen, Jun; Huang, Gaoshan; Feng, Sijia
  作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Fudan University; The Chinese University of Hong Kong, Shenzhen; Fudan University; Fudan University; Fudan University
  摘要：Biofilm-associated infections present a critical therapeutic challenge due to antibiotic resistance and impaired tissue healing. Here, we present a microrobotic system (MZ-8) that integrates real-time human-steered navigation with autonomous, microenvironment-responsive therapy to actively eradicate biofilms and promote tissue regeneration. This microrobotic system features a spine-inspired structure for mechanical biofilm disruption, a pH-responsive ZIF-8 coating for immunomodulatory Zn2+ rel...
• Small but mighty: The outsized role of small water bodies in the global carbon cycle AI翻译
  作者：Macedo, Marcia N.
  作者单位：Columbia University; Columbia University
• Reply to Yu et al.: Meteorological covariations do not reproduce diurnal cloud fraction response to aerosol AI翻译
  作者：Pugsley, Geoffrey; Gryspeerdt, Edward; Nair, Vishnu
  作者单位：Imperial College London
• mRNA lipid nanoparticle cancer vaccine platform delivering multiple STING activators for enhanced antitumor activity AI翻译
  作者：Zeng, Ye; Xu, Junchao; Wang, Jinjin; Xue, Lulu; Liu, Jiageng; Geisler, Hannah C.; Ma, Xu; Melamed, Jilian R.; Shi, Qiangqiang; Padilla, Marshall S.; Luo, Zhangyi; Zhu, Jingcheng; Thatte, Ajay S.; Figueroa-Espada, Christian G.; Ang, Melgious Jin Yan; Murray, Amanda M.; Yamagata, Hannah M.; Kim, Dongyoon; Metzloff, Ann E.; Weissman, Drew; Mitchell, Michael J.
  作者单位：University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, CAS; Agency for Science Technology & Research (A*STAR); A*STAR - Bioprocessing Technology Institute (BTI); University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania
  摘要：mRNA-based cancer vaccines offer a modular and safe platform to elicit antitumor immunity, yet their efficacy is often limited by inefficient mRNA delivery and inadequate dendritic cell (DC) activation, both of which are essential for initiating robust cytotoxic T cell responses. Inadequate innate immune activation coupled with poor antigen presentation further diminishes their effectiveness, particularly in immunologically cold tumors. While stimulator of interferon genes (STING) agonists can...
• Invariant nonequilibrium dynamics in gene regulation optimize information flow AI翻译
  作者：Zoller, Benjamin; Benichou, Alexis; Gregor, Thomas; Tkacik, Gasper
  作者单位：Universite Paris Cite; Pasteur Network; Centre National de la Recherche Scientifique (CNRS); Institut Pasteur Paris; Institute of Science & Technology - Austria; Princeton University
  摘要：Eukaryotic gene regulation relies on stochastic yet controlled promoter switching, in which genes transition between transcriptionally active and inactive states. Despite the molecular complexity of this process, recent studies have revealed a surprising invariance of the switching correlation time (TC)-the characteristic decay time of the autocorrelation function of promoter activity fluctuations-across gene expression levels in multiple genes and organisms. A biophysically plausible explanat...
• AI-assisted teams outperform AI-led teams but not human-only teams in assessing research reproducibility in quantitative social science (vol 123, e2524747123, 2026) AI翻译
  作者：Brodeur, Abel; Valenta, David; Marcoci, Alexandru; Aparicio, Juan P.; Mikola, Derek; Barbarioli, Bruno; Alexander, Rohan; Deer, Lachlan; Stafford, Tom; Vilhuber, Lars; Bensch, Gunther; Motoki, Fabio; Abdelhady, Mohamed; Abdelmoula, Yousra; Baki, Ghina Abdul; Aguirre, Tomas; Aiyer, Sriraj; Akhtar, Shumi; Akhtar, Farida; Albada, Melle R.; Altman, Micah; Angenendt, David; Lari, Zahra Arjmandi; Tejada, Jorge Armando De Leon; Arana, David Rodriguez; Asanov, Igor; Noha, Anastasiya-Mariya; Ashong, Rebecca; Auer, Tobias; Bahamonde-Birke, Francisco J.; Baker, Bradley J.; Bartram, Sohnke M.; Bao, Dongqi; Batinovic, Lucija; Batistoni, Tommaso; Beeder, Monica; Beland, Louis-Philippe; Bienz, Carsten Gero; Aryanto, Christ Billy; Bolibaugh, Cylcia; Bonander, Carl; Bravo, Ramiro; Bronnikov, Egor; Bruns, Stephan; Buliskeria, Nino; Caicedo-Silva, Sara; Calef, Andrea; Arias, Juan Sebastian Cano; Alvarez, Gustavo A. Castillo; Caulker, Solomon; Cepenas, Simonas; Chatton, Arthur; Chen, Zirou; Ewurum, Ngozi Chioma; Ciocirlan, Anda-Bianca; Clouth, Felix J.; Collins, Jason; Cook, Nikolai; Cornejo, Cesar; Craveiro, Joao; Crechet, Jonathan; Cui, Jing; Vayalabron, Niveditha Chalil; Czymara, Christian; Jaramillo, Carlos Daniel Bermudez; Datta, Hannes; Denoo, Lien; Dhaliwal, Arshia; Dhameja, Nency; Djemai, Elodie; Dujeancourt, Erwan; Dundar, Ugurcan; Duprey, Thibaut; Eissa, Yasmine; El Fassi, Youssef; El Fassi, Ismail; Ellis, Keaton; Elminejad, Ali; Elsherif, Mahmoud; Emirmahmutoglu, Aysil; Etingin-Frati, Giulian; Eze, Emeka; Dollbaum, Jan Fabian; Feld, Jan; Jaramillo, Andres Felipe Rengifo; Fenig, Guidon; Fernandes, Victoria; Fiala, Lenka; Fink, Lukas; Firouzjaeiangalougah, Mojtaba; Fish, Sara; Fitzgerald, Jack; Forshaw, Rachel; Fortier-Chouinard, Alexandre; Freget, Louis; Frese, Joris; Gabani, Jacopo; Gallegos, Sebastian; Gamill, Max C.; Gaspar, Attila; Gauriot, Romain; Gavrilova, Evelina; Geraldes, Diogo; Cantone, Giulio Giacomo; Gibson, Grant; Goldschmitt, Dirk; Gourdon-Kanhukamwe, Amelie; de Varda, Andrea Gregor; Grigoryeva, Idaliya; Gugushvili, Alexi; Fletcher, Aaron H. A.; Habermann, Florian; Hablicsek, Marton; Haddad, Joanne; Hall, Jonathan D.; Hammar, Olle; Hassouneh, Malek; Hausladen, Carina I.; Hendrikse, Sophie C. F.; Hepplewhite, Matthew; Ho, Anson T. Y.; Hogan-Hennessy, Senan; Howley, Elliot; Huang, Gaoyang; Hulstaert, Heloise; Ilchovska, Zlatomira G.; Santamaria, Paola Jaimes; Jakobsson, Niklas; Jansson, Joakim; Jarosz, Ewa; Jebeli, Hossein; Jiang, Yanchen; Junaid, Hiba; Kalluraya, Rohan; Karim, Sunny; Kelly, Edmund; Kimel, Eva; Kingsuwankul, Sorravich; Klotzbucher, Valentin; Krahmer, Daniel; Kruminas, Pijus; Kruus, Nicholas; Kujansuu, Essi; Kurz, Christoph F.; Kuster, Stephan; Lee-Whiting, Blake; Lewandowski, Felix; Li, Tongzhe; Li, Ruoxi; Liu, Dan; Liu, Jiacheng; Lo, Helix; Loter, Katharina; Dias, Felipe Macedo; Madan, Christopher R.; Mader, Nicolas; Mandas, Marco; Mantilla, Cesar; Marcus, Jan; Fages, Diego Marino; Martin, Xavier; McWay, Ryan; Medina-Gaspar, Daniel; Meng, Sisi; Meng, Lingyu; Merz, Simon; Miller, Alex P.; Mirabel, Thibault; Mishra, Dibya Deepta; Mishra, Sumit; Moges, Belay W.; Mojarrad, Morteza Mohandes; Mohnen, Myra; Morin, Louis-Philippe; Muehlenbachs, Lucija; Mullin, Gaston; Musulan, Andreea; Muzzi, Sara; Myers, James A. C.; Neubauer, Florian; Nguyen, Tuan; Niazi, Ali; Nordstrom, Ardyn; Nowak, Bartlomiej; O'Habib, Daneal; Olkers, Tim; Ong, Justin; Castiblanco, Valeria Orozco; Ozak, Omer; Ozkes, Ali I.; Paaso, Mikael; Pandey, Shubham; Papazoglou, Varvara; Penheiro, Romeo; Pham, Linh; Phieler, Ulrike; Putz, Peter; Qi, Quan; Qiu, Jingyi; Rein, Manuel T.; Reinstein, David A.; Repo, Juuso; Rudolf, Nicolas; Saha, Shree; Saka, Orkun; Saponaro, Chiara; Sator, Georg; Schoenmakers, Martijn; Seri, Raffaello; Shah, Meet; Sibille, Paul; Siemroth, Christoph; Skavysh, Vladimir; Slater, Ben; Song, Wenting; Staubli, Stefan; Steindl, Tobias; Waongo, Nomwende Steven; Stott, Paul; Strobel, Stephenson; Sudhaharan, Roshini; Sun, Pu; Swain, Scott D.; Talavera, Oleksandr; Tantiangco, Hanz M.; Tarasenko, Georgy; Tarlinton, Boyd; Tarraf, Mariam; Teoh, Ken; Theriault, Remi; Thompson, Bethan; Tian, Tonghui; Tian, Wenjie; Tolani, Emmanuel; Borgen, Nicolai; Borgen, Solveig Topstad; Torralba, Javier; Velez-Ospina, Carolina; Mak, Man Wai; Wallrich, Lukas; Wang, Zeyang; Ward, Leah; Webb, Matthew D.; Webb, Duncan; Weber, Bryan S.; Weber, Christoph; Weng, Wei-Chien; Westheide, Christian; Wilkinson, Tom; Wong, Kwong-Yu; Wronski, Marcin; Wu, Zhuangchen; Wu, Qixia; Wu, Victor Y.; Xiao, Bohan; Xu, Feihong; Xu, Cong; Yadav, Pranav; Chou, Yu Yang; Yap, Luther; Yazbeck, Myra; Yao, Bo; Zagrodzka, Zuzanna; Zahra, Tahreen; Zaneva, Mirela; Zhang, Xiaomeng; Zhao, Ziwei; Zhong, Han; Zirgulis, Aras; Zou, Jiacheng; Zoutman, Floris; Zozoungbo, Christelle
  作者单位：ISM University of Management & Economics
• Structural insights into the nairovirus nucleoprotein endonuclease activity AI翻译
  作者：Li, Zan; Du, Shan; Gao, Feng; Xiao, Yanshuang; Weng, Qilu; Zhang, Wenni; Chen, Pufei; Xu, Wenbo; Wang, Yuanzhi; Liu, Quan; Wu, Yan; Sun, Litao
  作者单位：Sun Yat Sen University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; University of Western Australia; Jilin University; Capital Medical University; Sun Yat Sen University
  摘要：Nairoviruses are emerging tick-borne pathogens for which effective antiviral therapies are currently unavailable. Although nucleoproteins (NPs) are essential for viral genome encapsulation and have been extensively characterized at the structural level, whether they perform additional functions during viral replication remains unclear. Here, we investigated the NP of the representative nairovirus Tacheng tick virus 1 (TcTV1). We found that the TcTV1 NP binds to nucleic acids in a sequence-inde...