Mesoscale developmental rivalry in the human extrastriate visual cortex

• 成果类型: Article
• 署名作者: Nasr, Shahin; Skerswetat, Jan; Kennedy, Bryan; Schmidt, Marianna E.; Gaier, Eric D.; Morland, Antony B.; Bex, Peter; Hunter, David G.
• 署名单位: Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Northeastern University; University of California System; University of California Irvine; Max Planck Society; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); University of York - UK; University of York - UK
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2600746123
• 发表日期: 2026-07-14
• 页码: e2600746123
• 关键词: development; extrastriate visual cortex; amblyopia; mesoscale functional organization; high-resolution fMRI; EARLY UNILATERAL BLUR; functional-organization; EXPERIMENTAL STRABISMUS; macaque monkeys; striate cortex; NEGATIVE BOLD; GLOBAL MOTION; disparity; areas; V2

摘要

The human extrastriate visual cortex contains fine-scale columns selectively responsive to motion, disparity, and color. However, the developmental interplay between these functional modules remains poorly understood. Using high-resolution functional MRI, we compared the mesoscale organization of the extrastriate cortex in 16 individuals with normal vision and 15 participants with amblyopia (PwA) caused by strabismus (n = 8) or anisometropia (n = 7). In controls, the cortical territory occupied by disparity-selective columns exhibited a competitive relationship with that of motion- and color-selective columns. In PwA, we witnessed a reduction in the size of disparity-selective columns accompanied by expansion of the cortical territory allocated to motion- and color-selective columns, while the interdigitated organization of these sites remained unchanged. At the macroscale, this phenomenon simply manifested as weaker disparity- plus stronger motion- and color-selective responses in PwA than controls. Our results show that the mesoscale modules are rivals in development allowing intact functions to usurp those that are compromised.