32期

最新文章

• Accelerating Campylobacter zoonosis in the Anthropocene AI翻译
  作者：Kyne, Oakem J.; Penman, Bridget S.; Kelly, David J.; Sheppard, Samuel K.
  作者单位：University of Oxford; University of Oxford; University of Sheffield
  摘要：Intensive poultry farming has transformed global bird populations, concentrating billions of chickens into dense industrial systems that fundamentally reshape ecological space. As birds are important pathogen reservoirs, these changes can have important consequences for the spread of zoonoses including Campylobacter jejuni-the leading cause of bacterial gastroenteritis. Analyzing 2,747 genomes from chickens and wild birds, we show that poultry intensification has eroded historic host-strain as...
• p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1 (vol 101, pg 14057, 2004) AI翻译
  作者：You, Han; Jang, YingJu; You-Ten, Annick Itie; Okada, Hitoshi; Wakeham, Andrew; Zaugg, Kathrin; Mak, Tak W.
• Rapid acceleration of ice-cover loss from Northern Hemisphere lakes above critical air temperature thresholds AI翻译
  作者：Zhou, Jian; Wang, Weijia; Ma, Yaru; Yuan, Linwang; Huang, Changchun; Shi, Kun; Leavitt, Peter R.
  作者单位：Nanjing Normal University; Nanjing Normal University; Bangor University; Chinese Academy of Sciences; Nanjing Institute of Geography & Limnology, CAS; University of Regina; University of Regina
  摘要：Widespread declines in lake-ice cover are a hallmark of climate warming, yet the dynamic sensitivity of ice cover to thermal forcing remains poorly understood across broad climatic gradients. By analyzing an extensive dataset from 724 Northern Hemisphere lakes between 2000 and 2022, we quantify the responsiveness of lake-ice phenology to changes in air temperature and project their future trajectories. Our hemispheric analysis reveals a pronounced asymmetrical sensitivity where ice-decay proce...
• A structural and mechanistic atlas of NTD antibody neutralization and immune escape across SARS-CoV-2 prototype and its (sub-)variants AI翻译
  作者：Zhou, Jianjie; Li, Wenyu; Wang, Xiaoyun; Sun, Junqing; Guo, Shuxin; Rong, Xiaoyu; Tong, Zhou; Dai, Lianpan; Liu, William Jun; Qi, Jianxun; Gao, George Fu; Wang, Qihui
  作者单位：Chinese Academy of Sciences; Institute of Microbiology, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Macau; Guangzhou Laboratory
  摘要：The N-terminal domain (NTD) of the SARS-CoV-2 spike (S) is a critical antibody target, yet its epitope organization, neutralization mechanisms, and immune evasion strategies remain incompletely resolved. Here, we classify NTD antibodies into nine spatially distinct classes (designated as NTD-1 to NTD-9), including a cryptic epitope defined here (NTD-8). Mechanistic studies reveal that NTD-5 and NTD-9 antibodies neutralize by inducing S1 shedding, thereby extending this mechanism to selected NT...
• A lettuce receptor-like kinase recognizes the highly conserved heptapeptide motif within microbial Nep1-like proteins AI翻译
  作者：Banales, Inigo; Mehrem, Sarah L.; Almeida Landman, Samara; Alderkamp, Marrit; Pijfers, Max; Baijens, Stan; von Bredow, Alix; Schutte, Peter; Prevoo, Sander; van Asselt, Gijs; Sagayaradj, Sagayamary; Snoek, Basten; Michelmore, Richard; Lapin, Dmitry; van den Ackerveken, Guido
  作者单位：Utrecht University; Utrecht University; University of California System; University of California Davis; University of California System; University of California Davis
  摘要：Plants rely on cell surface immune receptors to detect microbial patterns and initiate effective defense responses. Although the Asteraceae family is one of the largest and economically important plant groups, little information is available about its pattern-triggered immunity signaling. Cultivated lettuce (Lactuca sativa L.) recognizes a 24-amino acid peptide (nlp24) from necrosis- and ethylene-inducing peptide 1 (Nep1)-like proteins (NLPs) found in bacteria, fungi, and oomycetes. Here, we p...
• Energy prioritization and neurometabolic scaling in a social insect brain AI翻译
  作者：Coto, Zach N.; Ye, Dajia; Arganda, Sara; Harrison, Jon F.; Traniello, James F. A.
  作者单位：Boston University; Stanford University; Universidad Rey Juan Carlos; Universidad Rey Juan Carlos; Arizona State University; Arizona State University-Tempe
  摘要：Brains are metabolically costly and due to their high energetic demands may receive priority under conditions of reduced energy availability. Such preferential energy allocation to the brain has been described for humans and other mammals, but previous studies have not directly quantified brain metabolic rate or simultaneously considered whole-body metabolism. We recorded brain metabolic rate ex vivo, brain mass, body mass, and whole-body metabolic rate in workers of the ant Tetramorium immigr...
• Antibiotic tolerance coupled with limited benefit from drainage: Clinical challenges in Klebsiella pneumoniae liver abscess AI翻译
  作者：Gong, Zibo; Guo, Yawen; Liu, Xiwen; Wang, Zhe; Li, Guofei; Chang, Zhihui
• An interdependent Cbf1-CCAN interaction stabilizes the budding yeast kinetochore AI翻译
  作者：Hedouin, Sabrine; Hu, Changkun; Biggins, Sue
  作者单位：Fred Hutchinson Cancer Center
  摘要：Chromosome segregation requires the proper assembly of kinetochores on centromeric DNA. The kinetochore is a complex multiprotein machine comprising more than 40 distinct proteins, but the functional roles of many components remain unclear. One such protein is the yeast transcription factor Cbf1, which directly binds to budding yeast centromeric DNA. Loss of Cbf1 significantly increases the rate of chromosome missegregation; however, its precise molecular mechanism of action is unknown. It was...
• Implicit biases change more slowly in larger cities AI翻译
  作者：Stier, Andrew J.
  作者单位：The Santa Fe Institute
  摘要：Implicit biases remain a contributor to discrimination despite widespread endorsement of equality. Although there has been a large-scale reduction in sexuality, race, and skin tone biases in the past two decades, there is a current shortage of quantitative theories that describe how and why biases change. Here, I present a theory of implicit bias change, which focuses on changes in exposure due to cultural information and how the speed of these changes varies geographically. This model makes c...
• Identification of novel functional sites in the Cav1.3 calcium channel α1-subunit using evolutionary modeling AI翻译
  作者：Tang, Xuechen; Hermenean, Horia C.; Yakimchyk, Alesia; Tuluc, Petronel; Ortner, Nadine J.; Liedl, Klaus R.
  作者单位：University of Innsbruck; University of Innsbruck; Medical University of Graz
  摘要：Voltage-gated calcium channels (VGCCs) regulate differentiation, function, and survival of excitable cells, and pathogenic variants cause diverse disorders. Most known disease-associated VGCC mutations affect well-characterized regions controlling voltage-dependent gating and channel kinetics, while many residues remain functionally unannotated. We developed an evolutionary model to predict the pathogenic potential of residues in the pore-forming Cav1.3 subunit, previously validated with de no...