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作者：Balliot, David
作者单位：University of California System; University of California San Diego
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作者：Muller, Laura; Sartori, Fabio; Dehning, Jonas; Eggl, Maximilian F.; Priesemann, Viola
作者单位：Max Planck Society; University of Gottingen; Helmholtz Association; Karlsruhe Institute of Technology; Universidad Miguel Hernandez de Elche; University of Bonn
摘要：Mitigation measures are essential for controlling the spread of infectious diseases during pandemics and epidemics, but they impose considerable societal, individual, and economic costs. We developed a general framework that combines simulation of disease dynamics with optimal control to determine mitigation strategies that balance infection and mitigation costs. Optimizing this trade-off, we identified three surprising effects: first, assuming a constant reproduction number R0, the optimal re...
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作者：Ma, Suze; Li, Ru; Gao, Xiangyang; Gemmell, Eric; Guo, Sijia; Chen, Heng; Huang, Xuedong; Capper, Michael; Liu, Zhijun; Deng, Zixin; Ding, Wei; Kohnke, Jesko; Wang, Xiaohui; Zhang, Qi
作者单位：Jiangxi Normal University; Fudan University; Chinese Academy of Sciences; Changchun Institute of Applied Chemistry, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Xinjiang Agricultural Vocational & Technical University; University of Glasgow; Shanghai Jiao Tong University; Zhangjiang Laboratory; Chinese Academy of Sciences; Shanghai Advanced Research Institute, CAS
摘要：The symbiotic bacterium Photorhabdus is a rich source of bioactive secondary metabolites that mediate tripartite interactions with nematodes and insect hosts. However, natural products of ribosomal origin remain largely underexplored within this ecological niche. Here, we report the identification of aphotorhaptin A, a darobactin-like peptide (daropeptide) natural product from Photorhabdus asymbiotica, which structurally features an ether crosslink and an N-terminal acetyl unit. Biosynthetic i...
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作者：Shao, Yang; Wang, Songyang; Liang, Li; Gong, Biao; Johary, Aurore; Shi, Benhui; Zhang, Linyang; Xu, Yanqun; Joly-Lopez, Zoe; Luo, Zisheng; Bureau, Thomas E.; Sun, Jiaqi
作者单位：Shandong University; McGill University; Shandong Agricultural University; Shanghai Jiao Tong University; Zhejiang University; Shandong University
摘要：Salt stress severely impairs plant growth through two distinct cellular insults: osmotic stress caused by water limitation and ionic toxicity resulting from excessive Na+ accumulation. Although plant osmosensors have been identified, the mechanisms underlying ionic stress perception remain elusive. Salt stress also activates autophagy, a conserved degradation pathway that removes damaged organelles and protein aggregates to promote stress tolerance. In animals, master regulators such as transc...
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作者：Whitlam, Jade; Flohr, Pascal; Bogaard, Amy; Charles, Michael; Finlayson, Bill; Makarewicz, Cheryl A.
作者单位：University of Oxford; University of Oxford; University of Kiel; The Santa Fe Institute; University of Kiel
摘要：The domestication of plants in southwest Asia was an evolutionary process that took place over several millennia in the Early Holocene. During this time, domestic species developed distinct traits that distinguished them from their wild counterparts. Current models of plant domestication emphasize the role of genetic selection in the evolution of these traits, viewing these as heritable adaptations that arose in response to selective pressures associated with human cultivation. In cereals, dom...
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作者：Wolfe, Charles A.; Mendes, Tassia V.; Jackobs, Faith; Bench, Sarah; Ma, Emily X.; Armijo, Brian J.; Montgomery, Ashley E.; de Brito, Renan, V; Chone, Carlos T.; Eberlin, Marcos N.; Carvalho, Caroline P.; Ibrahim, Junaid; Huang, Andrew T.; Liou, Nelson E.; Sturgis, Erich M.; Tibshirani, Robert; Eberlin, Livia S.
作者单位：Baylor College of Medicine; Universidade Estadual de Campinas; Universidade Presbiteriana Mackenzie; Baylor College of Medicine; Baylor College of Medicine; Stanford University
摘要：Oral Cavity Squamous Cell Carcinoma (OCSCC) is a common and deadly form of head and neck cancer which disproportionately afflicts low-and middle-income communities. Since the majority of OCSCC lesions are visible within the oral cavity, visual exam-guided biopsy remains the standard method for detection. However, visual examination can be subjective, biopsy can be painful, and pathological evaluation can be time consuming. With the goal of developing an accessible and noninvasive platform for ...
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作者：Choi, Jihoon; Grandel, Nicolas; Awasthi, Deepika; Lee, Geonhui; Nigam, Abhishant; Shan, Yu; Soland, Nathan E.; Fonseca Guzman, Maria; Jo, Hye-jin; Pham, Diep N.; Yang, Peidong; Simmons, Blake A.
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Joint BioEnergy Institute - JBEI; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; Seoul National University (SNU)
摘要：Direct electrochemical CO2 reduction is currently limited to a narrow range of multicarbon products due to limited multicarbon pathways on Cu surfaces. Biochemical methods, by contrast, are often slow due to the slow rate of gas-liquid mass transfer to microbial cells. To overcome the limitations of the individual processes, integrating electrochemical systems with biosynthetic processes has become a promising approach. However, only a narrow range of microbial strains has been explored in the...
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作者：Engel, Botond; Szikriszt, Bernadett; Gyure, Zsolt; Sale, Julian E.; Szuts, David; Nemeth, Eszter
作者单位：HUN-REN; HUN-REN Research Centre for Natural Sciences; Semmelweis University; MRC Laboratory Molecular Biology
摘要：DNA damage occasionally leads to mutations even in DNA repair-proficient cells via translesion synthesis (TLS), an efficient but error-prone DNA damage tolerance pathway. In the human genome, there are three closely related Y-family TLS polymerases (eta, kappa, and iota). Polymerase eta is specialized for the error-free replication of UV adducts, while polymerase kappa is known to replicate over various heterocyclic DNA adducts. The function of polymerase iota is less clear and this gene is mi...
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作者：Epper, Thomas F.; Fehr, Ernst; Hvidberg, Kristoffer B.; Kreiner, Claus T.; Leth-Petersen, Soren; Zafar, Basit
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite de Lille; IESEG School of Management; University of Zurich; Aarhus University; University of Copenhagen; University of Michigan System; University of Michigan
摘要：We examine whether individual preferences predict higher-education choices. According to standard human capital theory, differences in individuals' time and risk preferences lead to differences in educational investments. Testing this hypothesis is challenging, as it requires measuring individuals' preferences, doing so before they make educational investments, and subsequently observing their educational choices. We combine incentivized, experimentally elicited measures of time and risk prefe...
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作者：Rolseth, Amanda Bryn; Beurg, Maryline; Konrad, Dakota Elle; August, Benjamin K.; Fettiplace, Robert
作者单位：University of Wisconsin System; University of Wisconsin Madison
摘要：Mutations in transmembrane channel-like protein 1 (TMC1), the pore-forming component of the mechano-electrical transducer (MET) channel in auditory hair cells, cause cell death and deafness in 3-wk old mice. We studied mice with mutations Tmc1 p.T416K, p.M412K, p.D528N, and p.D569N, which possessed functional MET channels at postnatal day (P)6 but became deaf before P21. These Tmc1 mutants had channels with reduced Ca2+ permeability and lower expression of the PMCA2 calcium pump in outer hair ...
