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作者：Bidochka, Michael J.
作者单位：Brock University
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作者：Saha, Tamoghna; Khan, Muhammad Inam; Longardner, Katherine; Sabbagh, Barak; Zheng, Kaiwen; de Mendoza, Hugo; Ji, Gaoyuan; Choi, Bumsik; Wang, Zongnan; Pham, Rosie; Skipworth, Michael; Shah, Eshita; Reynoso, Maria; Moonla, Chochanon; Abdal, Abdulhameed; Datta, Debika; Sandhu, Samar Singh; Nandhakumar, Ponnusamy; Jedrzak, Artur; Ding, Shichao; Yin, Lu; Litvan, Irene; Wang, Joseph
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：Precision management of Parkinson's disease (PD) requires frequent levodopa (L-dopa) dose adjustments, yet current monitoring relies on subjective symptom reporting and infrequent blood testing. Here, we present a soft, fingertip-mounted wearable platform for continuous, noninvasive L-dopa monitoring. By combining osmotically harvested passive sweat with soft hydrogels, a potentiometric sensing strategy, and individualized calibration, the platform estimates blood L-dopa information from sweat...
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作者：Campana, Michael G.; Venkatraman, Madhvi X.; Tsuchiya, Mirian T. N.; Kearns, Anna M.; VanTassel, Nichelle M.; Henschen, Amberleigh E.; Przelomska, Natalia A. S.; McInerney, Nancy Rotzel; Ochirbat, Margad-Erdene; Lerner, Heather R. L.; Callicrate, Taylor E.; Hagemann, Molly; Paxton, Eben H.; Cassin-Sackett, Loren; James, Helen F.; Fleischer, Robert C.
作者单位：Smithsonian Institution; Eastern Illinois University; University of Wisconsin System; University of Wisconsin Madison; University of Portsmouth; Smithsonian Institution; Smithsonian National Museum of Natural History; Royal Botanic Gardens, Kew; University of Louisiana Lafayette; Smithsonian Institution; Smithsonian National Museum of Natural History; Amherst College
摘要：The Hawaiian honeycreepers, one of the world's most iconic adaptive radiations, are facing a human-mediated extinction crisis. More than 60 Hawaiian honeycreepers (Fringillidae: Carduelinae: Drepanidini) evolved from a single rosefinch-like ancestor that colonized the Hawaiian Islands. Only 17 Hawaiian honeycreeper taxa are known to be extant, of which only the common 'amakihi (Chlorodrepanis virens) and 'apapane (Himatione sanguinea) are classified as Least Concern. Using mitogenome, whole-ge...
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作者：Deutsch, Rebecca; Jors, Simone; Klingl, Yvonne; Kudrina, Veronika; Menegaz, Danusa; Jaslan, Dawid; Serianz, Zala; Vogel, Andreas; Abrahamian, Carla; Bhunia, Sayari; Tavhelidse-Suck, Tinatini; Richter, Christin; Wirth, Angela; Urban, Nicole; Northoff, Bernd; Wilfert, Wolfgang; Klugbauer, Norbert; Bracher, Franz; Keller, Marco; Geisler, Fabian; Schaefer, Michael; Teupser, Daniel; Holdt, Lesca; Belkaya, Serkan; Freichel, Marc; Grimm, Christian
作者单位：University of Munich; University of Munich; Technical University of Munich; German Heart Centre Munich; Technical University of Munich; Ruprecht Karls University Heidelberg; Leipzig University; University of Munich; University of Freiburg; University of Munich; Ihsan Dogramaci Bilkent University; University of Oxford
摘要：Iron overload is a life-threatening disease. Without early diagnosis and treatment, it can cause severe organ damage and even premature death by irreversibly damaging organs such as the heart, pancreas, spleen, or liver. We report here that a gain-of-function mutation in the endolysosomal two-pore channel TPC1 (TPC1I486T) causes iron overload in mice, whereas mice lacking TPC1 exhibit the opposite phenotype, iron deficiency. Endolysosomal patch-clamp experiments demonstrated a strong gain in b...
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作者：Liu, Yaowu; Zhang, Zichun; Chen, Sidan; Xu, Shengnan; Ji, Lichen; Chen, Wei; Zhou, Xinyu; Hu, Xiaopeng; Duan, Wenhui; Chen, Xi; Xue, Qi-Kun; Ji, Shuai-Hua
作者单位：Tsinghua University; Institute for Basic Science - Korea (IBS); Ewha Womans University; Beijing Academy of Quantum Information Sciences; Southern University of Science & Technology
摘要：Charged impurities are one of the dominant sources for carrier scattering in modern electronic devices, and their impact significantly increases as the size of devices approaches atomic limitation, making it essential to understand how carriers scatter off impurities at the atomic level. Despite the importance, the electronic transport behaviors, especially the local electrochemical potential distribution induced by electrical current, around charged impurities have remained experimentally elu...
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作者：Lotlikar, Madhura S.; Ayotte, Beatrice; Choi, Amy; Seo, Freddie; Robertson, Edwin M.; Maso, Fabien Dal; Roig, Marc
作者单位：McGill University; National Institute of Information & Communications Technology (NICT) - Japan
摘要：Sleep loss is a public health concern requiring widely accessible cost-effective interventions to counteract the cognitive and brain health impairments caused by it. Sleep loss impairs the brain's capacity to form new episodic memories, which is critical for everyday cognition, future planning, and decision-making. In this study, we compared the protective effect of a 20-min exercise and a 90-min nap against a no-intervention control condition on the capacity to encode episodic memory after 30...
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作者：Ma, Xiaohui; Asamiya, Ian; Louie, Elizabeth; Chen, Ying; Li, Aiqun; Xu, Pin-Xian
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
摘要：The mammalian auditory sensory epithelium consists of hair cells (HCs), whose stereociliary bundles convert sound-evoked vibrations into electrical signals, and supporting cells (SCs), which provide mechanical stability. The transcription factor SIX1 is essential during otic neurosensory cell specification and HC commitment, but its contribution after birth has remained elusive. Here, we show that SIX1 is required for maintaining the structure and function of the adult cochlear sensory epithel...
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作者：Scholz, Florian; Doetterl, Sebastian; Hardisty, Dalton S.
作者单位：University of Hamburg; Swiss Federal Institutes of Technology Domain; ETH Zurich; Michigan State University
摘要：Formation and burial of pyrite (iron sulfide) in marine sediments exert a fundamental control on atmospheric oxygenation and seawater buffering over geological timescales. However, little is known about how the formation and delivery of its precursor, reactive iron (Fe) oxide minerals, have evolved throughout Earth history. Secular variability in reactive Fe (including Fe oxides and pyrite) preserved in marine sediments is commonly attributed solely to redox changes. Here, we develop an approa...
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作者：Usami, Fumiko Matsukawa; Arata, Masaki; Kato, Kagayaki; Shi, Dongbo; Oka, Sanae; Yang, Yingzi; Fujimori, Toshihiko
作者单位：National Institutes of Natural Sciences (NINS) - Japan; National Institute for Basic Biology (NIBB); Graduate University for Advanced Studies - Japan; National Institutes of Natural Sciences (NINS) - Japan; Okazaki Institute for Integrative Bioscience (OIIB); National Institute for Basic Biology (NIBB); Harvard University
摘要：The luminal epithelium of the oviduct exhibits ciliary beating oriented along the ovary-uterus (O-U) axis, driving oocyte transport toward the uterus. Longitudinal epithelial folds have also been proposed to facilitate this transport, but their functional contribution has not been tested because the mechanisms that orient these folds remain unclear. In this study, we found that in Vangl1gt/gt oviducts, which lack the core planar cell polarity (PCP) protein VANGL1, ciliary beating orientation i...
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作者：McDermott, Amy
