32期

最新文章

• Checkpoint-insulated triple-signal artificial antigen-presenting cells drive antigen relay and systemic antitumor immunity AI翻译
  作者：Zhao, Siyu; Shi, Tianzi; Tian, Tianyi; Zhang, Fangming; Zhang, Zitong; Xu, Hongbo; Zhou, Yixuan; Li, Zhilang; Qin, Zhaojing; Xu, Pengwen; Yang, Conglian; Zhang, Zhiping
  作者单位：Huazhong University of Science & Technology; Sun Yat Sen University; Huazhong University of Science & Technology
  摘要：Dendritic cell (DC) vaccines offer professional antigen presentation but are often limited by suboptimal trafficking to lymphoid tissues, whereas whole tumor cell vaccines preserve antigenic diversity yet frequently lack coordinated activation cues for efficient T cell priming. Here, we report OncoAPC, an inactivated artificial antigen-presenting cell designed around a triple-signal priming logic: MHC-I-mediated antigen presentation (signal 1), CD80-mediated costimulation (signal 2) with check...
• Juvenile hormone receptor relies on conserved domain interfaces for dimerization-dependent activity AI翻译
  作者：Bittova, Lenka; Tumova, Sarka; Yatsenko, Mykola; Mokhamatam, Raveendra Babu; Tuma, Roman; Jindra, Marek
  作者单位：Czech Academy of Sciences; Biology Centre of the Czech Academy of Sciences; University of South Bohemia Ceske Budejovice
  摘要：Juvenile hormone (JH) is vital to insects. In Drosophila, JH signals through a basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) protein methoprene-tolerant (MET) and its paralog germ cell-expressed (GCE). Binding of JH to the PAS-B domain of MET or GCE triggers the assembly of a DNA-bound, transcriptionally active JH receptor (JHR) heterodimer comprising either MET or GCE and their partner taiman (TAI). Molecular mechanisms of the JHR complex activation remain unclear. Here, we use the Drosophil...
• CIP2A-TOPBP1 complex and PP2A dynamically regulate Polθ recruitment and phosphorylation at mitotic DNA double-strand breaks AI翻译
  作者：Zhao, Xipeng; Chen, Bin; Xu, Feng; Zhang, Jie; Yao, Zhicheng; Wang, Ruru; Zhou, Shenglan; Hou, Yao; Xu, Shangkun; Xu, An; Wu, Lijun; Zhao, Guoping
  作者单位：Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS; Mayo Clinic; Anhui University; Anhui Medical University
  摘要：DNA double-strand breaks (DSBs) that occur during mitosis are primarily repaired by Pol theta-mediated microhomology-mediated end joining (MMEJ). The CIP2A-TOPBP1 complex has been shown to tether broken chromatin at mitotic DSBs, but whether it coordinates with or functions independently of Pol theta remains unknown. Here, we show that the CIP2A-TOPBP1 complex is recruited to mitotic DSB sites, where it directly interacts with Pol theta and corecruits Pol theta to chromatin. CIP2A sustains Pol...
• The EV-A71 RNA-binding protein Matrin 3 facilitates viral replication by stabilizing viral RNA via ZDHHC20-mediated palmitoylation AI翻译
  作者：Zuo, Xiaoyan; Chen, Yongjun; Xiao, Xia; Xiang, Zichun; Ren, Lili; Lei, Xiaobo; Wang, Jianwei
  作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College
  摘要：Enterovirus 71 (EV-A71) is a major causative agent of severe hand, foot, and mouth disease (HFMD) in young children. However, the molecular interplay between EV-A71 and host factors, particularly how these interactions govern viral replication, remains incompletely understood. To systematically identify host factors involved in EV-A71 infection, we performed comprehensive identification of RNA-binding proteins (RBPs) by mass spectrometry (ChIRP-MS) during viral infection and identified 374 hos...
• Mapping the exposome-microbiota-host axis for prenatal origins of infant health AI翻译
  作者：Chen, Minjian; Duan, Jiawei; Guan, Yusheng; Xu, Yuntian; Jiang, Yingtong; Li, Ziyi; Huang, Rui; Zhou, Jingjing; Covaci, Adrian; Aase, Heidi; Wang, Xinru; Xia, Yankai
  作者单位：Nanjing Medical University; Nanjing Medical University; Nanjing Medical University; University of Antwerp; Norwegian Institute of Public Health (NIPH)
  摘要：Prenatal exposures influence infant health, yet the microbiota related mechanisms remain unclear. We profiled 776 maternal exposome variables and meconium microbiota in 1,689 mother-infant pairs, establishing a network linking maternal exposures, neonatal microbiota, and 10 infant outcomes. Using multiomics, pathway enrichment, and robust regression, we identified maternal anthropometrics and clinical indicators as key predictors of infant development, and specific metabolic and chemical expos...
• 撤稿声明: Macrophage TBK1 signaling drives the development and outgrowth of breast cancer brain metastasis AI翻译
  作者：Khan, Fatima; Liu, Yang; Whitfield, Donovan; Pang, Lizhi; Ali, Heba; Huang, Yuyun; Zhou, Fei; Hagan, Robert S.; Frenis, Katie; Rowe, R. Grant; Chen, Peiwen
• Multistep electron tunneling through tryptophans in the KatG bifunctional peroxidase monitored by a nonperturbing spin probe (vol 123, e2612169123, 2026) AI翻译
  作者：Mileo, Elisabetta; Piero, Annalisa; Lojou, Elisabeth; Cheruzel, Lionel; Gray, Harry B.; Ivancich, Anabella
• Controlled generation of 3D vortices in driven atomic Josephson junctions (vol 123, e2535111123, 2026) AI翻译
  作者：Singh, Vijay Pal; Mathey, Ludwig; Ott, Herwig; Amico, Luigi
  作者单位：Technology Innovation Institute; University of Hamburg; University of Hamburg; University of Hamburg; RPTU University Kaiserslautern; University of Catania; Istituto Nazionale di Fisica Nucleare (INFN)
• Evolution after whole-genome duplication (WGD) drives phenotypic and transcriptomic divergence more than WGD in an autopolyploid herb AI翻译
  作者：Grunig, Sandra; Choudhury, Rimjhim Roy; Parisod, Christian
  作者单位：University of Fribourg; University of Bern
  摘要：Whole-genome duplication (WGD) is a major driver of plant speciation and often hypothesized to promote rapid adaptation to new or changing environmental conditions. However, the extent to which WGD per se fosters phenotypic and transcriptional novelties, and the relative contribution of WGD-induced changes vs post-WGD evolution to trait differentiation between cytotypes remains poorly understood. Here, we investigated the phenotypic and transcriptomic consequences of WGD and subsequent evoluti...
• Highly localized droplet clustering in shallow cumulus clouds AI翻译
  作者：Thiede, Birte; Larsen, Michael L.; Nordsiek, Freja; Schlenczek, Oliver; Kim, Yewon; Bodenschatz, Eberhard; Bagheri, Gholamhossein
  作者单位：Max Planck Society; University of Gottingen; Michigan Technological University; Cornell University
  摘要：The size and spatial clustering of water droplets in warm clouds influence cloud evolution and radiation properties and thus are of fundamental importance for the Earth's energy balance and water cycle. Some proposed mechanisms for droplet growth and precipitation initiation in warm clouds require strong droplet clustering. Resolving such clustering on sub-cm scales remains a challenge. The most detailed observations, collected from aircraft, showed weak mm-scale droplet clustering averaged ov...