32期

最新文章

• The dynamics of introgression and parallel adaptation across North American Vitis species AI翻译
  作者：Wang, Tianpeng; Fiscus, Christopher J.; Landis, Jacob B.; Cochetel, Noe; Morales-Cruz, Abraham; Cantu, Dario; Aguirre-Liguori, Jonas A.; Gaut, Brandon S.
  作者单位：University of California System; University of California Irvine; Cornell University; University of California System; University of California Davis; United States Department of Energy (DOE); Joint Genome Institute - JGI; Lawrence Berkeley National Laboratory; University of California System; University of California Davis; Universidad Autonoma de Yucatan
  摘要：Hybridization between species can contribute to parallel adaptive events. However, the prevalence of introgression is rarely measured across multiple species, meaning that it is rarely integrated with landscape-scale processes or connected to adaptive repeatability. Here we analyzed whole-genome resequencing data from 639 accessions representing 48 Vitis species. Vitis is notable for the domesticated grapevine (Vitis vinifera), multiple economically important North American species, and as an ...
• AI-driven PROTAC design overcomes oncogenic resilience by eliminating the CLIP1-LTK fusion protein AI翻译
  作者：Chen, Shicheng; Duan, Haiting; Zhong, Sheng; Ge, Jingxuan; Zhao, Huifeng; Ye, Yuanyi; Sun, Huiyong; Li, Dan; Kang, Yu; Dong, Xiaowu; Che, Jinxin; Hou, Tingjun; Pan, Peichen
  作者单位：Zhejiang University; Sun Yat Sen University; State Key Lab Oncology South China; China Pharmaceutical University; Zhejiang University
  摘要：The discovery of CAP-Gly domain-containing linker protein 1(CLIP1)-Leukocyte tyrosine kinase (LTK) as an oncogenic fusion reveals a unique dependency not only on LTK kinase activity but also on CLIP1-mediated multimerization, a noncatalytic function that drives oncogenic signaling. While this fusion is currently targeted with anaplastic lymphoma kinase inhibitors, their exclusive focus on kinase inhibition leaves the scaffolding function intact, necessitating a complete protein clearance strat...
• Stochastic game dynamics under demographic fluctuations (vol 112, pg 9064, 2015) AI翻译
  作者：Huang, Weini; Hauert, Christoph; Traulsen, Arne
• Cell surface ADGRG1 and CD86 expression identifies antitumor CD4+ T cells in human cancer AI翻译
  作者：Hitscherich, Kyle J.; Dinerman, Aaron J.; Hakim, Abraham A.; Dulemba, Victoria; Sindiri, Sivasish; Gasmi, Billel; Bera, Alakesh; Gartner, Jared J.; Prickett, Todd D.; Yu, Zhiya; Li, Yong F.; Ratnam, Nivedita M.; Gustafson, Alexandra M.; Bhasin, Aarushi; Parkhurst, Maria R.; Klemen, Nicholas D.; Kwong, Mei Li M.; Yang, James C.; Robbins, Paul F.; Goff, Stephanie L.; Rosenberg, Steven A.; Krishna, Sri; Lowery, Frank J.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
  摘要：Adoptive cell transfer of tumor infiltrating CD4(+) T cells or T cells genetically modified to express antitumor CD4(+) T cell receptors (TCRs) has shown clinical efficacy in patients with advanced solid tumors. We previously defined unique transcriptomic states of antitumor, neoantigen-specific CD8(+) and CD4(+) tumor infiltrating lymphocytes (TIL) in human cancer. However, optimal cell surface protein markers that identify and would enable viable cell isolation and selective enrichment of an...
• Unveiling previously undescribed circadian clock regulators and action mechanisms via TurboID-based profiling of the LWD1 interactome in Arabidopsis thaliana AI翻译
  作者：Huang, Chun-Kai; Hsu, Chuan-Chih; Tsai, Huang-Lung; Lin, Wen-Dar; Wu, Jing-Fen; Wu, Shu-Hsing
  作者单位：Academia Sinica - Taiwan; National Taiwan University
  摘要：The synchronization of the internal circadian clock with the external 24-h diel cycle is critical for plant growth and fitness. LIGHT-REGULATED WD proteins (LWDs) are essential for sustaining a precise and robust circadian clock in Arabidopsis [Y. Wang et al., Plant Cell 23, 486-498 (2011); J. F. Wu et al., Nat Commun. 7, 13181 (2016)]. However, the action mechanisms by which LWDs orchestrate the expression of clock genes remain largely elusive. We systematically identified 219 LWD1-interactin...
• Nature's antivenom: Combinations of conserved rattlesnake serum metalloproteinase inhibitors block the lethal action of viper venoms AI翻译
  作者：Carroll, Sean B.; Ukken, Fiona P.; Ayinuola, Yetunde A.; Escalona, Luis; Suntravat, Montamas; Sanchez, Elda E.
  作者单位：University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park
  摘要：Snakebite maims or kills several hundred thousand people each year. For more than a century, treatment has relied on antivenoms derived from animals immunized with whole venoms, but their efficacy, safety, and availability are highly variable, and it is often not well understood which specific venom components must be inhibited to prevent mortality and major morbidities. New therapeutic approaches are needed. Here, we take an evolutionary approach to antivenom design inspired by the longstandi...
• Deep learning maps local brain aging in relation to cognition across human adulthood AI翻译
  作者：Chaudhari, Nikhil N.; Vega Huerta, Owen M.; Bhattacharya, Samayan; Chowdhury, Nahian F.; Irimia, Andrei
  作者单位：University of Southern California; University of London; King's College London
  摘要：Brain aging, the strongest risk factor for Alzheimer's disease (AD), varies across cortical regions. Global brain age (GBA), an imaging-derived measure of neuroanatomic decline, reduces structural aging to a single summary value. This can potentially obscure regional patterns of cognitive vulnerability preceding AD. This study introduces a deep-learning architecture trained on the T 1 -weighted MRIs of 14,748 cognitively normal (CN) participants from multiple sites to estimate local brain age ...
• Attention to heterogeneous information sources affects epidemic outcomes AI翻译
  作者：Li, Jiayu; Cheung, Matthew; Arango, Marcela Ordorica; Leonard, Naomi Ehrich; Levin, Simon A.
  作者单位：Princeton University; Princeton University; Princeton University; Princeton University
  摘要：During an epidemic, disease transmission and human behavior are closely related: High infection levels trigger risk awareness and preventive behaviors, which suppress the transmission of disease. While these coupled dynamics have been heavily investigated, both in well-mixed populations and networked populations, less has been done to explore how different ways to establish the awareness of disease affect infection levels. This study presents a mathematical model of two interacting groups (pop...
• Co-phase separation of KRI1 and NPM1 sustains nucleolar integrity and ribosome biogenesis to fuel liver cancer progression AI翻译
  作者：Lu, Yu; Gan, Lunbiao; Ru, Wenxiu; Guo, Yujing; Huang, Qian; Yin, Sha; Nie, Fengze; Di, Sijia; Yao, Siyu; Wan, Huanhuan; Yang, Fa; Qin, Weijun; Wen, Weihong
  作者单位：Northwestern Polytechnical University; Air Force Medical University
  摘要：Liver cancer is the fourth leading cause of global cancer mortality, with hepatocellular carcinoma (HCC) accounting for most primary liver cancers. The nucleolus, as the primary site of ribosome biogenesis, plays a crucial role in HCC development. Here, we report that the nucleolar protein KRR1 interacting protein (KRI1) is aberrantly overexpressed in HCC tissues and interacts with nucleophosmin 1 (NPM1) via phase separation to maintain nucleolar structure and ribosome biogenesis. Downregulati...
• A TCR-mimic bispecific antibody reduces HIV-1 provirus and delays viral rebound in HLA-matched humanized mice AI翻译
  作者：Yuan, Zhe; Board, Nathan L.; Zhao, Miaoyun; Zu, Guorui; Sengupta, Srona; Li, Qingsheng; Siliciano, Janet D.; Siliciano, Robert F.; Montaner, Luis J.
  作者单位：The Wistar Institute; Johns Hopkins University; Johns Hopkins Medicine
  摘要：Bispecific antibodies that reroute cytotoxic effectors toward infected cells are promising HIV-1 cure agents, yet existing formats bind Env and are limited by antigenic variation and Env down-regulation. We engineered a TCR-mimic single-chain diabody, HI12, that recognizes a conserved Pol-derived peptide presented by HLA-A*02:01 and evaluated its effect in HLA-matched, HIV-infected humanized mice. When administered during early antiretroviral therapy (ART), HI12 was well tolerated, activated C...