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作者：Galvani, Alison P.; Heckman, James J.; Holt, Robert D.; Levin, Simon A.
作者单位：Yale University; University of Chicago; State University System of Florida; University of Florida; Princeton University
摘要：Burton Singer, elected to the National Academy of Sciences in 1994 and the National Academy of Medicine in 2005, died on February 15, 2026, at age 87. Moving seamlessly across statistics, epidemiology, economics, demography, ecology, and public health, his career transcended conventional academic boundaries. He brought the rigor of stochastic process theory to problems ranging from labor market dynamics and demographic change to tropical disease epidemiology, public health policy, and environm...
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作者：Kilmer, Beau
摘要：This article provides a primer on illegal drug markets, with a focus on the structure and nature of these markets and the enterprises involved. The markets for illegal drugs are large, with annual retail expenditures likely exceeding $100 billion in the United States alone. Many drugs are easy to produce, and their high value-to-weight ratios make them attractive to smugglers. Some features of illegal drug markets have been quite stable, such as the small size of retail purchases, in part beca...
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作者：Massari, Marta; Caroli, Jonatan; Malatesta, Marco; Marchese, Sara; Sente, Filip; Pizzorni, Letizia; Mattevi, Andrea
作者单位：University of Pavia
摘要：IL4I1, a human L-amino acid oxidase (LAAO), has drawn considerable interest for its role in catabolism with implications for cancer biology and immune modulation. The function and activity of this enzyme in humans contrast with the cytotoxic effects exerted by LAAOs from snake venoms. The inherent instability of IL4I1 has hindered detailed biochemical characterization and its exploration as a drug target. In this study, we present a comprehensive biochemical and structural investigation of tet...
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作者：Papameletiou, Anna-Maria; Nicholson, Benjamin Czech; Bornelov, Susanne; Hannon, Gregory J.
作者单位：Cancer Research UK; CRUK Cambridge Institute; University of Cambridge; University of Cambridge
摘要：Transposable elements (TEs) are a highly diverse group of selfish genomic elements, prevalent across the tree of life, whose uncontrolled propagation poses a threat to genome stability. Recent studies have explored the evolution of Drosophila melanogaster TEs, their coevolution with the host genome, and mechanisms that regulate their activity. However, little is known about their cross-species evolutionary patterns. Long terminal repeat (LTR) retrotransposons are the most active group of TEs i...
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作者：Peng, Zhennan; Liu, Haoran; Wang, Huaxi; Long, Runying; Yang, Qin; Lu, Zigang; Xu, Wenjun; Yin, Zhiwei; Zhang, Liming; Zhang, Feiran; Tian, Xiaodong; Ji, Xianglin; Jiang, Zijian; Chen, Yi; Lu, Haonan; Dai, Hongjie
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作者：Swain, Daniel L.
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作者：Zhang, Chengqi; Liu, Shijie; Shen, Tao; Yu, Cunlong; Chu, Fuqiang; Jiang, Lei; Dong, Zhichao
作者单位：Chinese Academy of Sciences; Technical Institute of Physics & Chemistry, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Beihang University; University of Science & Technology Beijing
摘要：With the persistent threats from severe respiratory diseases and airborne pollutants, billions of people worldwide lack timely access to essential diagnostic services, particularly in low-resource regions where laboratory infrastructure is scarce. Conventional pump-suction airborne samplers face challenges including cost, power dependency, and unavoidable analyte loss in complex systems. Here, we demonstrate a film-rupture actuated capillary enrichment (FACE) airborne sampler that replaces ext...
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作者：Zhou, Lifan; Wen, Zhiyan; Zhong, Chenchen; Zhang, Dingliang; Zhang, Qianshen; Wang, Ruiqi; Duan, Jiangning; Zhang, Kun; Li, Zhen; Zhao, Xiaoyun; Mei, Aodong; Wang, Yuanzhi; Zhou, Tong; Du, Linlin; Chu, Jinfang; Cheng, Shujing; Zhao, Xiaofei; Yang, Meng; Li, Dawei; Dinesh-Kumar, Savithramma P.; Zhang, Yongliang
作者单位：China Agricultural University; Yangzhou University; Jiangsu Academy of Agricultural Sciences; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of California System; University of California Davis; University of California System; University of California Davis
摘要：The role of lipid droplets (LDs), typically regarded as storage sites for neutral lipid, in plant defense remains poorly understood. In our study with barley stripe mosaic virus (BSMV), a (+)ssRNA virus, we found that infection significantly increases LD abundance in Nicotiana benthamiana and wheat. Using split-TurboID-based proximity labeling, we identified LD-associated proteins (LDAPs) at ER-chloroplast contact sites. Increasing LD formation by overexpressing mouse FIT2 or plant NbLDAP2.1 d...
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作者：Qian, Yifan; Wen, Zhe; Furnas, Alexander C.; Bai, Yue; Shao, Erzhuo; Wang, Dashun
作者单位：Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University
摘要：Federal research funding shapes the direction, diversity, and impact of the US scientific enterprise. Large language models (LLMs) are rapidly diffusing into scientific practice, holding substantial promise while raising widespread concerns. Despite growing attention to AI use in scientific writing and evaluation, little is known about how the rise of LLMs is reshaping the public funding landscape. Here, we examine LLM involvement at key stages of the federal funding pipeline by combining two ...
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作者：Roldan, Maria Victoria Gomez; Yan, Yuhang; Du, Yujuan; Charlot, Florence; Perroud, Pierre-Francois; Calbry, Julie; Griess, Ofir; Verdenaud, Marion; Marcel, Fabien; Citerne, Sylvie; Tran, Joseph; Ohad, Nir; Coudert, Yoan; Nogue, Fabien; Bendahmane, Abdelhafid
