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作者：Li, Qingrong; Hou, Peini; Kimoto, Michiko; Oh, Juntaek; Liu, Yan; Tan, Hui Pen; Chong, Jenny; Hirao, Ichiro; Wang, Dong
作者单位：University of California System; University of California San Diego; Kyung Hee University; Kyung Hee University; Kyung Hee University; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：Expanded genetic alphabets based on synthetic nucleotides offer a powerful strategy to increase the chemical diversity and functional potential of nucleic acids. Hydrophobic unnatural base pairs (UBPs) represent a unique class of UBPs that operate without canonical hydrogen bonding and shapes, which are distinct from natural base pairs. However, the molecular mechanisms governing hydrophobic UBP recognition and incorporation by RNA polymerases remain poorly understood, because no structures of...
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作者：Puigdelloses Vallcorba, Montserrat; Rawat, Kavita; Soni, Nishant; DiMauro, Angela; Chu, Jacqueline D.; Thomason, Wes; Furtado, Glaucia C.; Strahl, Maya; Wu, Junyan; Joshi, Tanvi; Angione, Angelo; Pinero, Gonzalo; Becher, Oren J.; Ross, James L.; Tsankov, Alexander M.; Lira, Sergio A.; Hambardzumyan, Dolores
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of Pennsylvania; Pennsylvania Medicine; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of Virginia; University of Virginia (UVA) Health System; University of Virginia
摘要：Diffuse midline gliomas (DMGs) are highly aggressive, WHO grade 4 glial tumors that arise in midline central nervous system structures and are defined by K27M mutations in histone H3 genes. These K27M mutations shape intratumoral myeloid cell composition in DMG. In H3.1K27M DMGs, genetic ablation of monocyte recruitment reshapes the tumor microenvironment (TME) by reducing monocyte-derived macrophages (MDMs) and increasing microglia and neutrophil presence, with overall survival remaining unch...
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作者：Diaz Tovar, Johan Sebastian; dos Reis, Flavio Pola; Moriyama, Lilian Tan; Pego-Fernandes, Paulo Manuel; Nomura, Cesar Higa; Yakovlev, Vladislav; Bagnato, Vanderlei Salvador; Doronin, Alexander; Kurachi, Cristina
作者单位：Texas A&M University System; Texas A&M University College Station; Victoria University Wellington
摘要：Light therapies, such as photobiomodulation and photodynamic therapy, have demonstrated effective therapeutical response. However, external irradiation and targeting internal organs is challenging due to high light attenuation and the interindividual anatomical variability, strongly affecting light dosimetry. When considering lung diseases, such as pneumonia and inflammatory conditions, light dosimetry using transcutaneous delivery must consider the total light path from skin coupling through ...
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作者：Schneider, Friedrich Martin; Thom, Andreas
作者单位：Technical University Freiberg; Technische Universitat Dresden
摘要：We prove that the unit group of a nondiscrete irreducible, continuous ring, in the sense of John von Neumann, does not admit any nontrivial unitary representation continuous with respect to the strong operator topology.
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作者：Zuo, Jiaqi; Cao, Shuo; Tang, Ying; He, Haitao; Zhang, Jie; Li, Peiru; Chen, Yanke; Yin, Ping; Wang, Chuang; Xiong, Lizhong; Dong, Faming; Liu, Zhu
作者单位：Huazhong Agricultural University
摘要：Vacuoles store up to 90% of cellular phosphorus in plants, serving as a critical buffer against cytosolic fluctuations during environmental nutrient stress. Despite this central role, the molecular mechanisms governing vacuolar inorganic phosphate (Pi) release through vacuolar Pi efflux transporters (VPEs) remain unclear. Through integrative structural biology, we elucidate how the rice transporter OsVPE2 transports Pi out of vacuoles. Cryoelectron microscopy structures capture distinct functi...
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作者：Kim, Jongwan; Jang, Seong-Hoon; Lee, Jonghoon; Hopper, Corbin; Cho, Kwang-Hyun
作者单位：Korea Advanced Institute of Science & Technology (KAIST)
摘要：Cellular processes often exhibit irreversible state transitions even after external signals responsible for a transition are withdrawn. Long-standing questions remain: Where does such irreversibility originate from and can it be reversed? Although positive-feedback circuits among cellular components are known to relate to irreversibility, which circuits hold the dynamical origin of such irreversibility within large complex molecular networks remains unknown. Moreover, identifying the structura...
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作者：Lance, Rachel M.; Makowski, Matthew S.; Mahon, Richard T.; Everitt, Jeffrey I.; Natoli, Michael J.; Wright, Mary C.; Howle, Laurens E.; Bartlett, Nicholas C.; Patel, Aashay; Morales, Gabriela; Moon, Richard E.
作者单位：Duke University; Duke University; University of Texas System; University of Texas Medical Branch Galveston; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc; Duke University; Duke University; Duke University
摘要：Decompression sickness (DCS) risk limits human undersea operations through tissue inert gas supersaturation and pathological bubble formation. Switching the inert breathing gas prior to decompression to a gas with lower diffusivity could allow faster and safer decompression. This principle was tested in 20 kg swine after a helium-oxygen (He/O2) dive using carbon tetrafluoride. Sedated swine breathed He/O2 79/21 at a pressure equivalent of 200 feet of seawater (714 kPa) in a hyperbaric chamber ...
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作者：Matsumura, Kentarou; Tanaka, Keisuke; Sasaki, Ken; Shimomura, Kenji; Miyatake, Takahisa
作者单位：University of Tokyo; Tokyo University of Agriculture; Tamagawa University; Tokyo University of Agriculture; Okayama University
摘要：Phenotypic traits often covary through shared genetic and environmental influences, shaping the evolution of integrated life-history strategies. In particular, correlations between behavioral and life-history traits form the core of the pace-of-life syndrome (POLS) hypothesis, yet direct experimental tests of its evolutionary and molecular foundations remain limited. Here, we combined experimental evolution and transcriptomic analyses to investigate the phenotypic and molecular architecture of...
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作者：Midgette, Greg; Gore, Meredith L.
作者单位：RAND Corporation; University System of Maryland; University of Maryland College Park; University System of Maryland; University of Maryland College Park
摘要：Illegal wildlife markets comprise a complex global economy generating criminal profits while harming biodiversity and livelihoods. The negative externalities from biodiversity loss, ecosystem destabilization, and zoonotic disease risk may be orders of magnitude larger than the multibillion dollar annual total market value. Despite decades of international policy attention, fundamental economic characteristics of these markets remain poorly understood. We suggest distinguishing three categories...
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作者：Pearson, Samuel G.; Hornsey, Matthew J.; Haslam, S. Alexander
作者单位：University of Queensland; University of Queensland
