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作者：Wang, Siyu; Zhong, Yichen; Wang, Chang; Tian, Meng; Bennett, Jeffrey L.; Bliss-Moreau, Eliza; Xue, Yonger; Yu, Changyue; Hou, Xucheng; Zheng, Ya Ying; Li, Haoyuan; Liu, Zhengwei; Cao, Dinglingge; Kang, Diana D.; Deng, Binbin; Dong, Yizhou
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of California System; University of California Davis; University of California System; University of California Davis; University System of Ohio; James Cancer Hospital & Solove Research Institute; Ohio State University; University System of Ohio; Ohio State University
摘要：Messenger RNA (mRNA) therapeutics hold potential for central nervous system (CNS) disease treatment. However, the blood-brain barrier (BBB) presents a major obstacle, preventing efficient delivery of mRNA into the brain. To overcome this challenge, we designed, synthesized, and tested a series of ionizable lipids and formulated them into CNS-accessing lipid nanoparticles (CA LNPs) to deliver mRNA. The lead candidate among them, CA2d LNP, demonstrated efficient mRNA delivery across the BBB foll...
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作者：Colasanti, Jason J.; Santeford, Andrea; Lin, Joseph B.; Terao, Ryo; Lee, Tae Jun; Apte, Rajendra S.
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); University of Tokyo; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
摘要：Age-related macular degeneration (AMD), characterized by pathologic choroidal neovascularization (CNV), is a leading cause of vision loss in the elderly. Vascular endothelial growth factor A (VEGFa) antagonists can prevent acute vision loss, but high treatment burden and loss of efficacy with chronic therapy highlight the need to explore alternative mechanisms. Recently, microRNA-34a (miR-34a) has emerged as a key regulator in aging and age-related diseases, but its role in neovascular AMD is ...
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作者：Kennedy, Jay P.
摘要：Product counterfeiting is a pervasive crime that involves the unauthorized use of a legitimate trademark, a violation of intellectual property rights. Counterfeiting is also one of many forms of global illicit trade, mirroring legitimate markets in structure and reach. Counterfeit goods span nearly every product category from luxury items and electronics to pharmaceuticals and military components, posing risks that range from consumer deception to threats to public health. The globalization of...
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作者：Poirier, Alexandre J.; Feng, Chu-Han; Walback, Erika; Su, Rui; Hincapie, Ana Maria; Aubry, Isabelle; Wu, Chenyue; St-Laurent, Elisabeth; Uttam, Sonali; Colalillo, Bianca; Hardy, Serge; Dore, Samuel; Theberge, Jean-Francois; Tremblay, Michel L.
作者单位：McGill University; McGill University; McGill University; McGill University
摘要：Immune evasion by cancer cells remains a major barrier to the success of immune checkpoint blockade (ICB). In recent years, Protein tyrosine phosphatase non-receptor type 2 (PTPN2) has emerged as a promising and druggable target for cancer immunotherapy. Small-molecule agents currently in clinical development to inhibit PTPN2 also exhibit substantial activity against the closely related phosphatase PTPN1. However, the relative contribution of each phosphatase and its direct effect in cancer ce...
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作者：Qiu, Haoyi; Miraucourt, Lois S.; Petitjean, Hugues; Xu, Mengyi; Theriault, Catherine; Davidova, Albena; Soubeyre, Vanessa; Poulen, Gaetan; Lonjon, Nicolas; Vachiery-Lahaye, Florence; Bauchet, Luc; Levesque-Damphousse, Philipa; Estall, Jennifer L.; Bourinet, Emmanuel; Sharif-Naeini, Reza
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作者：Wen, Qin; Liu, Zhengyu; Wang, Tao; Ji, Chengwei; Liu, Jian; Cheng, Hai; Yan, Mi; Ning, Liang; Jing, Zhaowei; Liu, Heng; Lei, Jing; Lu, Jiuyou; Creutzig, Felix; Yin, Qiuzhen
作者单位：Nanjing Normal University; Nanjing Normal University; University System of Ohio; Ohio State University; Nanjing Normal University; Xi'an Jiaotong University; Beijing Forestry University; Chinese Academy of Sciences; Institute of Earth Environment, CAS; Laoshan Laboratory; Potsdam Institut fur Klimafolgenforschung; Potsdam Institut fur Klimafolgenforschung
摘要：South Asian summer monsoon (SASM) delivers substantial rains to the Indian subcontinent and drives strong upwelling in the Arabian Sea, making marine upwelling records and terrestrial rainfall records two primary proxies for reconstructing past SASM variability. However, on orbital timescales, these two sets of records vary largely in opposite directions: the upwelling records are in-phase with Southern Hemisphere (SH) summer insolation, whereas the rainfall records are in-phase with Northern ...
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作者：Keuzenkamp, Joep; Mazza, Jacopo; Rijkers, Bob; Stapleton, Katherine
作者单位：Utrecht University; The World Bank; The World Bank
摘要：Governments across the globe are turning to place-based industrial policies to make the green transition more equitable and politically palatable. The United States' Inflation Reduction Act exemplifies this approach through its Energy Community provisions, which offer additional tax incentives for clean energy projects in regions reliant on fossil fuels. We use spatially granular data on renewable energy investment, employment, and voting, and document that these incentives substantially incre...
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作者：Tagirdzhanova, Gulnara; Brown, Noah E.; Bucknell, Angus H.; Cameron, Ellen S.; Finn, Robert D.; Blaxter, Mark; McDonald, Megan C.; Gluck-Thaler, Emile; Talbot, Nicholas J.
作者单位：University of East Anglia; Stockholm University; University of Wisconsin System; University of Wisconsin Madison; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; Wellcome Trust Sanger Institute; University of Birmingham; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：Lichens are symbiotic associations between filamentous fungi and photosynthetic micro-organisms, such as green algae and/or cyanobacteria, that result in a single anatomically complex structure that can thrive in environments inhospitable to most organisms, including arctic tundra, high mountains, and deserts. Recent evidence suggests that lichens may be even more complex than previously appreciated, containing multiple microbial constituents, but how genomes of the principal fungal symbiont (...
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作者：Zhang, Xiujuan; Habib, Ariful; McFarlin, Shane; Richart, Donovan; Park, Soo Yeun; Cheng, Fang; Wang, Jinxi; Yan, Ziying; Qiu, Jianming
作者单位：University of Kansas; University of Kansas Medical Center; University of Alabama System; University of Alabama Birmingham; University of Kansas; University of Kansas Medical Center
摘要：The adeno-associated virus receptor (AAVR; also known as KIAA0319L) is the proteinaceous receptor required for the transduction of multiserotype adeno-associated viruses (AAVs). While the extracellular polycystic kidney disease (PKD) domains of AAVR directly bind AAV capsids, the function of its C-terminal cytosolic domain (AAVR-C) in governing AAV internalization and intracellular trafficking remains undefined. Using targeted pulldown of AAVR-interacting host proteins with a glutathione S-Tra...
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作者：Pilgrim, Charlie; Bate, Andrew M.; Sigalou, Anna; Aellen, Melisande; Morford, Joe; Warren, Elizabeth; Krupenye, Christopher; Biro, Dora; Mann, Richard P.
作者单位：University of Leeds; Consejo Superior de Investigaciones Cientificas (CSIC); University of Rochester; Johns Hopkins University
摘要：Collective vigilance describes how animals in groups benefit from the predator detection efforts of others. Empirical observations typically find either a many-eyes strategy with all (or many) group members maintaining a low level of individual vigilance, or a sentinel strategy with one (or a few) individuals maintaining a high level of individual vigilance while others do not. With an analytical treatment that makes minimal assumptions, we show that these two strategies are alternative soluti...
