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作者：Shah, Parth R.; Han, Chang-Ho; Abdel-Fattah, Amr; Squires, Todd M.
作者单位：University of California System; University of California Santa Barbara; Saudi Aramco; Korea Institute of Science & Technology (KIST)
摘要：Nonequilibrium colloidal transport mechanisms such as diffusiophoresis and Marangoni transport enable rapid and targeted delivery of colloids by exploiting in-situ or externally imposed chemical gradients, particularly in systems like dead-end pores where pressure-driven flow is ineffective. However, the duration of such transport is limited by how long the driving gradient persists. Here, we present a general strategy to prolong gradient-driven colloidal transport in dead-end channels using c...
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作者：Caulkins, Jonathan P.
作者单位：Carnegie Mellon University
摘要：Illegal markets create untold societal and environmental harm, but they have attracted surprisingly little scholarly attention. This paper explores illegal markets as a class of objects. It considers similarities and differences across markets, with particular attention to nine: human smuggling, commercial sex, firearms, money laundering, illegal fishing, international wildlife trafficking, counterfeit goods, drugs, and tobacco products. These nine markets display enormous variation, stemming ...
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作者：Schartman, Anna K.; Polissar, Pratigya J.; Stromberg, Caroline A. E.
作者单位：University of California System; University of California Santa Cruz; University of Washington; University of Washington Seattle
摘要：Like many of Earth's subtropical open ecosystems, the African savanna originated in the Miocene Epoch (23.0 to 5.3 Ma), one of the best historical analogs for future climate states. The first C(4)grass, C(3)tree, and shrub savanna developed in the subtropics after similar to 10 Ma in northwest Africa, but the terrestrial sedimentary record of the region is not well preserved, making it difficult to determine when, how, and why the African landscape opened. Here, we leverage plant-wax biomarker...
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作者：Sun, Jiace; Chan, Garnet Kin-Lic
作者单位：California Institute of Technology; California Institute of Technology
摘要：Many computational methods in ab initio quantum chemistry are formulated in terms of high-order tensor contractions, whose cost determines the size of system that can be studied. We introduce stochastic tensor contraction to perform such operations with greatly reduced cost, and present its application to the gold-standard quantum chemistry method, coupled cluster theory with up to perturbative triples. For total energy errors more stringent than chemical accuracy, we reduce the computational ...
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作者：Zhou, Wei; Wang, Xiangyu; Steigleder, Susanne S.; Xing, Aowei; Yang, Dan; Li, Zhuoyue; Liu, Hongji; Zhang, Yuxin; Wang, Wenjing; Shen, Feiyang; Tang, Yihan; Deng, Lin; Jiang, Hui
作者单位：Harbin Institute of Technology; University of Cologne; Shenzhen Bay Laboratory
摘要：Inflammation exerts context-dependent influences on tumor progression and therapeutic response. Although chemotherapy remains a cornerstone of cancer treatment, its functional interplay with inflammatory signaling is still incompletely understood. Here, we identify TANK-binding kinase 1 (TBK1) as a critical modulator of chemotherapeutic efficacy through its impact on DNA damage repair. TBK1 activation potentiates cancer-cell death induced by chemotherapeutic agents by promoting DNA damage and ...
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作者：Feng, Pengchao; Gao, Peng; Meng, Shaodong; Yuan, Yunxia; Krainer, Adrian R.; Hua, Yimin
作者单位：Nanjing Normal University; Cold Spring Harbor Laboratory
摘要：Antisense-mediated exon skipping has been used to treat Duchenne muscular dystrophy (DMD) by restoring the DMD reading frame to express partially functional dystrophin. However, difficulty in designing effective antisense oligonucleotides (ASOs) has hindered the development of clinically effective therapies. Here we describe a robust bipartite ASO design, termed 5 ' splice site decoy (5D)-ASO, in which a short tail sequence is employed to enhance the splicing repression exerted by an antisense...
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作者：Kim, Min Jae; Shen, Xinhang; Lee, Min Kyung; Hocky, Glen M.; Pine, David J.
作者单位：New York University; New York University; New York University
摘要：Colloidal crystals with the cubic diamond structure are attractive templates for three-dimensional photonic band-gap materials, but their self-assembly is hindered by the need for tetrahedral coordination and staggered next-nearest-neighbor bonds, which together impose substantial kinetic barriers in previously realized DNA-mediated systems. Here we demonstrate an entropically guided, non-site-specific route to colloidal diamond that uses the depletion interaction to assemble tetrahedrally lob...
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作者：Mitchison, Timothy J.
作者单位：Harvard University; Harvard Medical School
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作者：Chi, Wei; Li, Fei; Chen, Hongrui; Wang, Yandong; Zhu, Yingting; Yang, Xuejiao; Zhu, Jie; Wu, Frances; Ouyang, Hong; Ge, Jian; Weinreb, Robert N.; Zhang, Kang; Zhuo, Yehong
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作者：Le Billon, Philippe; Ladefoged, Zelda; Sumaila, U. Rashid
作者单位：University of British Columbia; University of British Columbia; University of British Columbia
摘要：About 3.5 million fishing vessels ply the world's oceans, providing livelihoods and food for millions of people. Sound management is key to fisheries' sustainability, but illegal fishing, along with fishing overcapacity generally and environmental change, are putting many fisheries at risk. Illegal fishing is a globally pervasive yet unevenly distributed phenomenon, manifesting in diverse forms across both small-scale and industrial-scale fleets, the latter accounting for about 82 to 93% of th...
