33期

最新文章

• High-yield charge separation along the alternative path in a photosynthetic reaction center: X-ray structure and electrostatic analysis AI翻译
  作者：Keable, Stephen M.; Wei, Rongmei Judy; Buhrmaster, James C.; Hippleheuser, Stephen; Makita, Hiroki; Simon, Philipp S.; Tira, Gregory A.; Kretzschmar, Moritz; Bogacz, Isabel; Faries, Kaitlyn M.; Lan, Anthony; Nangca, Isabela I.; Zhang, Miao; Doyle, Margaret D.; Chernev, Petko; Bhowmick, Asmit; Paley, Daniel W.; Sauter, Nicholas K.; Brewster, Aaron S.; Tono, Kensuke; Owada, Shigeki; Yano, Junko; Yachandra, Vittal K.; Gunner, M. R.; Kirmaier, Christine; Holten, Dewey; Hanson, Deborah K.; Laible, Philip D.; Kern, Jan F.
  作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; City University of New York (CUNY) System; City University of New York (CUNY) System; United States Department of Energy (DOE); Argonne National Laboratory; Humboldt University of Berlin; Washington University (WUSTL); Uppsala University; RIKEN; Japan Synchrotron Radiation Research Institute; City University of New York (CUNY) System; United States Department of Energy (DOE); Oak Ridge National Laboratory
  摘要：In all photosynthetic reaction centers (RC), transmembrane electron-transfer (ET) cofactor pathways are coordinated by homologous peptides and arranged with approximate C2 symmetry, providing two possible paths for charge separation (designated A and B). In type II RCs-Photosystem II and the purple bacterial RCs-only the A branch is active for ET. A variant bacterial RC containing nine amino acid substitutions that result in high-yield ET along the normally nonfunctional B branch was designed....
• Mitigating China's food-related water scarcity and spatial inequality via integrated basin-city management AI翻译
  作者：Liu, Jinliang; Zhuang, Minghao; Wang, Changbo; Feng, Meili; Zha, Donglan; Li, Hao; Hu, Xiurong; Ren, Yanan; Pang, Mingyue; Wang, Qunwei; Zhang, Lixiao
  作者单位：Nanjing University of Aeronautics & Astronautics; Nanjing University of Aeronautics & Astronautics; Nanjing University of Aeronautics & Astronautics; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Research Center for Eco-Environmental Sciences (RCEES), CAS; University of Nottingham; University of Nottingham Ningbo China; Chongqing University; Beijing Normal University
  摘要：Food production is constrained by water availability at the basin scale, whereas the governance of food trade primarily operates at the city scale. This spatial mismatch hinders the sustainable development of both food and water systems. To bridge this gap, we develop an integrated framework that combines hydrological (basin) and administrative (city) scales and apply it to China to quantify how virtual water flows embedded in food trade affect inequality in water allocation across and within ...
• Molecular assembly as a universal biosignature measurable by mass spectrometry AI翻译
  作者：Rutter, Lindsay A.; Sharma, Abhishek; Seet, Ian; Alobo, David Obeh; Goto, An; Cronin, Leroy
  作者单位：University of Glasgow
  摘要：Detecting life beyond Earth requires biosignatures that do not depend on the chemistry of known organisms. Molecular assembly (MA), derived from Assembly Theory, quantifies how difficult it is to build a molecule from basic building blocks, linking complexity directly to selection and evolution. Here, we show that MA can serve as a universal biosignature that is both interpretable and experimentally measurable. Unlike information-theoretic measures, MA can be inferred directly from mass spectr...
• The illegal market for sex in the United States: Insights from economic research AI翻译
  作者：Shah, Manisha
  作者单位：University of California System; University of California Berkeley
  摘要：The illegal market for sex in the United States generates significant economic activity yet remains understudied due to its illegality and clandestine nature. This paper synthesizes existing empirical evidence documenting aspects of market structure, impacts of regulation, and notable changes over time. Criminalization, while intended to suppress the market, often exacerbates harms by displacing activity underground, increasing violence against sex workers, and elevating disease transmission r...
• Complete deletion of the DMD gene provides insights into the function of dystrophin AI翻译
  作者：Chamberlain, Jeffrey S.
  作者单位：University of Washington; University of Washington Seattle
• The inhibitory receptor CD200R educates ILC1s for optimal cytotoxicity AI翻译
  作者：Chen, Yawen; Zhang, Zhengfeng; Wang, Xianwei; Zheng, Xiaodong; Chen, Yongyan; Sun, Rui; Sun, Haoyu; Tian, Zhigang; Peng, Hui
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Fudan University; Fudan University; Fudan University
  摘要：Conventional natural killer (cNK) cells are educated through inhibitory receptor engagement with MHC-I ligands, which endows them with potent cytotoxicity and robust IFN-gamma production. Although type 1 innate lymphoid cells (ILC1s) exhibit analogous functionality, whether they undergo a similar education process remains unclear. Our study reveals that the inhibitory receptor CD200R educates ILC1s for optimal cytotoxic competence but is dispensable for IFN-gamma production. Unlike cNK cells, ...
• Decision rules diverge between sympatric Featherfin cichlids despite shared preferences, ecology, and evolutionary history AI翻译
  作者：Tomasek, Maelan; Dunster, Boyd; Goverts, Zoe; Naceur, Dylan; Dufour, Valerie; Jordan, Alex
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Clermont Auvergne (UCA); CNRS - National Institute for Biology (INSB); Max Planck Society
  摘要：It has been hypothesized that divergence in animal decision processes can be attributed to differences in information processing mechanisms. However, the required comparative tests of this idea are hindered by ecological, perceptual, or motivational divergence among species that confound a direct analysis of decision processes. To overcome these limitations, we study two closely related, sympatric cichlid fishes (Aulonocranus dewindti and Cyathopharynx furcifer) that share visual capacities, e...
• Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8+ T cell-macrophage interactions AI翻译
  作者：McCaffrey, Erin F.; Delmastro, Alea C.; Singh, Bindu; Devi, Annu; Munson, Caden W.; Priyanka; Golden, Nadia A.; Khader, Shabaana A.; Angelo, Michael; Kaushal, Deepak; Mehra, Smriti
  作者单位：Stanford University; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Tulane University; University of Chicago
  摘要：Granulomas, the hallmark of tuberculosis (TB) disease, can both restrict Mycobacterium tuberculosis (Mtb) dissemination and impede its clearance. Recent studies indicate that indoleamine 2,3-dioxygenase (IDO1), an immunosuppressive metabolic enzyme, limits infiltration of activated T cells and can contribute to TB disease progression. Treatment with 1-methyl-D-tryptophan (D-1MT), a small molecule inhibitor that restores mTOR signaling, has been shown to reduce IDO1 activity and improve immune ...
• Beyond brassinosteroids: BSL phosphatases control asymmetric cell division in the Arabidopsis zygote AI翻译
  作者：Park, SungWoo; Muroyama, Andrew
  作者单位：University of California System; University of California San Diego
• Beyond non-significant results: Why and how to test for practical equivalence AI翻译
  作者：Tomek, Jakub; Caldwell, Aaron; Eisner, David A.
  作者单位：University of Oxford; University of Manchester
  摘要：Reporting comparisons with P >= 0.05 as showing no effect or no difference remains one of the most widespread and problematic misinterpretations in the scientific literature. A statistically nonsignificant result shows only that the data do not provide strong evidence for a difference. This distinction matters because such findings can arise for two very different reasons: Either there is no meaningful difference, or a meaningful difference is present but cannot be detected reliably because of...