33期

最新文章

• Associations between county-level racial attitude bias and disparities in Advanced Placement participation AI翻译
  作者：Park, Yeji; Riddle, Travis; Sinclair, Stacey
  作者单位：Princeton University
  摘要：While much attention has been paid to racial disparities in basic academic attainment, relatively less attention is given to racial disparities in excellence-participation in and performance within opportunities to develop and demonstrate high achievement. The present research investigates how racial attitude bias relates to disparities in participation in the Advanced Placement (AP) program, a paradigmatic opportunity for excellence in the US education system. We examined whether regional rac...
• Paintable on-skin dry electrodes with robust skin and device connection for wireless sensing and human-machine interfaces (vol 123, e2615835123, 2026) AI翻译
  作者：Zhang, Wanqing; Xin, Xin; Wang, Yuqi; Zhang, Xianzhe; Zhang, Senhao; Yuan, Yangbo; Xia, Shihao; Abdullah, Abu Musa; Zohra, Fatema Tuz; Li, Bowen; Yang, Jia-Yu; Dutta, Ankan; Liu, Zhuo; Lima, Anna Beatriz Pacheco; Yan, Su; Zhong, Jun; Chuang, Cheng-Hsin; Cheng, Huanyu
• The market for human smuggling: Structure, mechanisms, and paradoxes AI翻译
  作者：Campana, Paolo
  作者单位：University of Cambridge
  摘要：Human smuggling is the facilitation of unlawful cross-border movement. It is primarily a commercial activity, offered as a service to willing, paying customers, and a large-scale market catering to millions seeking to circumvent mobility restrictions. Contrary to prevailing media and political narratives that depict smuggling as dominated by powerful and highly sophisticated criminal organizations, this study documents a fragmented, decentralized market composed of independent, localized actor...
• Cryptic small-molecule binding sites in the ARID1B DNA-binding domain AI翻译
  作者：Carbone, Christine E.; Schonherr, Heike; Zhao, Victor Y.; Pierce, Levi; He, Jing; Shortsleeves, Kelley C.; Babik, Sandor; Venter, Philip A.; Krueger, Elaine B.; Fortin, Pascal D.; Wilbur, Jeremy D.; Holliday, Michael J.
  摘要：Genetic depletion of ARID1B has been shown to act in a synthetically lethal manner to selectively kill cancer cells with mutations in the tumor suppressor ARID1A, one of the most frequently altered proteins in human cancer. However, no precision therapeutic targeting ARID1B in ARID1A-mutant cancer has been developed due to the lack of a classically druggable small-molecule binding pocket on ARID1B. Here, we carried out molecular dynamics simulations on the small, globular AT-rich Interaction D...
• Suppression of EGFR signaling and drug-induced potentiation are widespread features of oncogenic RTK fusions AI翻译
  作者：Gao, Yuzhi (Carol); Gonzalez-Martinez, David; Wissert, Sofia; Bader, Hana; Sahni, Nidhi; Le, Anh; Doebele, Robert C.; Bugaj, Lukasz J.
  作者单位：University of Pennsylvania; University of Colorado System; University of Colorado Anschutz
  摘要：Regulation of cancer cells by their environment contributes to tumorigenesis and drug response, though the extent to which the oncogenic state can alter a cell's perception of its environment is not clear. EML4-ALK is a receptor tyrosine kinase (RTK) fusion oncoprotein that suppresses transmembrane EGFR signaling in cancer cells. ALK inhibition restores signaling through EGFR, thereby promoting survival and drug tolerance. Here, we tested whether such modulation of EGFR activity was common amo...
• UV photodamage pathways and the evolutionary selection of thymine over uracil in early genetic systems AI翻译
  作者：Khosh Abady, Keyvan; Karpourazar, Negar; Rentzepis, Peter M.
  作者单位：Texas A&M University System; Texas A&M University College Station
  摘要：The evolutionary selection of thymine over uracil in DNA presents a paradox from a photostability perspective, since thymine is found to be more susceptible to photodamage from the intense UV radiation present on the early Earth. This study addresses this paradox by providing a comparative spectroscopic analysis of thymine and uracil under controlled 265 nm UV irradiation. To that effect, we used steady-state absorption, fluorescence, and Raman spectroscopy to quantify and compare the photoche...
• Microbiota-derived isovalerate ameliorates sex-specific gut barrier dysfunction in malnutrition AI翻译
  作者：Lynch, Lauren E.; Soni, Krishnakant G.; Spinler, Jennifer K.; Ambati, Chandra Shekar R.; Putluri, Nagireddy; Fowler, Stephanie W.; Conner, Margaret E.; Nguyen-Phuc, Hoa; Zeng, Xi-Lei; Blutt, Sarah E.; Estes, Mary K.; Preidis, Geoffrey A.
  作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine
  摘要：Malnutrition increases intestinal permeability and the risk of sepsis, yet mechanisms underlying malnutrition-induced gut barrier dysfunction are poorly defined. Here, we aimed to determine how the gut microbiome and microbiota-derived metabolites influence intestinal barrier function in the malnourished host. We induced malnutrition in specific pathogen-free (SPF) and germ-free (GF) mice using a low-protein, low-fat diet. Colonic permeability was quantified in Ussing chambers and invasive bac...
• A solution to generalized learning from small training sets found in infants' repeated visual experiences of individual objects AI翻译
  作者：Ramirez, Frangil M.; Clerkin, Elizabeth M.; Crandall, David J.; Smith, Linda B.
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington
  摘要：One-year-old infants rapidly form and generalize categories from idiosyncratic experiences of very few exemplars of those categories. Here we provide evidence on the statistics of infants' daily-life visual experiences for 8 object categories. Using a corpus of infant head-camera images recorded at mealtimes (87 mealtimes,14 infants), we measure the frequency of the unique instances of each category and the variability of the visual experiences within and across instances of the same category....
• Distinct transcriptional logics of catechol siderophore transporters in Pseudomonas aeruginosa for efficient iron acquisition AI翻译
  作者：Volck, Florian; Revillot-Schmidt, Anne-Eloise; Hubert, Thibaut; Crespin, Victor; Mislin, Gaetan L. A.; Cunrath, Olivier; Madec, Morgan; Schalk, Isabelle J.
  作者单位：Universites de Strasbourg Etablissements Associes; Centre National de la Recherche Scientifique (CNRS); Universite de Strasbourg; CNRS - National Institute for Biology (INSB); Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; CNRS - Institute for Engineering & Systems Sciences (INSIS); Universite de Strasbourg
  摘要：With 21 outer-membrane transporters dedicated to iron acquisition, Pseudomonas aeruginosa possesses an extensive toolkit for securing this essential nutrient, but activates the expression only of those relevant to its immediate environment. Eighteen of these pathways rely on siderophores, two produced by P. aeruginosa and the others acquired from neighboring microorganisms through a siderophore-piracy strategy. Using fluorescent reporters and mathematical modeling, we quantified how catechol-t...
• Chromosomal inversions accelerate genetic evolution and drive ecological speciation across an island gradient AI翻译
  作者：Gomez-Ramos, Ines; Sanchez-Villegas, Rogelio; Mohan, Ashwini V.; Lavergne, Christophe; Cerca, Jose; Marquez-Corro, Jose I.; Marques, Andre; Martin-Bravo, Santiago; Luceno, Modesto; Lucek, Kay; Escudero, Marcial
  作者单位：University of Sevilla; University of Neuchatel; University of Oslo; Swedish Museum of Natural History; SciLifeLab; Max Planck Society
  摘要：Chromosomal rearrangements are hypothesized to facilitate speciation by suppressing recombination in locally adapted genomic regions, yet how they shape evolutionary rates during rapid divergence remains poorly understood. Here, we investigate the genomic architecture of two sister Carex (Cyperaceae) species on R & eacute;union Island, which rapidly diverged (similar to 0.5 Mya) to occupy contrasting tropical-montane and dry-subalpine habitats. Using chromosome-level assemblies and population ...