35期

最新文章

• Multidomain interaction governs the filamentous assembly of the dominant-negative DNMT3A R882H mutant AI翻译
  作者：Chen, Jianbin; Lu, Jiuwei; Long, Zhixu; Yoon, Sol; Fukunaga, Megan; Song, Jikui
  作者单位：University of California System; University of California Riverside
  摘要：DNA methyltransferase DNMT3A-mediated de novo DNA methylation is important for proper regulation of gene expression and genomic stability in development. The DNMT3A R882H (DNMT3AR882H) mutation, a hot-spot mutation in acute myeloid leukemia and developmental disorders, exerts a dominant-negative effect in DNMT3A-mediated DNA methylation through promoting high-order protein assembly. However, due to the lack of structural knowledge on DNMT3A homo-oligomers, the mechanism behind wild-type DNMT3A...
• Aging limits neuronal regeneration from glia in the mouse retina AI翻译
  作者：Deka, Jugasmita; Han, Ying; Bhattacharya, Sucheta; Sutton, Samantha; Bachay, Galina; Brunken, William J.; Todd, Levi
  作者单位：State University of New York (SUNY) System; SUNY Upstate Medical University; State University of New York (SUNY) System; SUNY Upstate Medical University
  摘要：Reprogramming resident glia into neurons holds great therapeutic promise for neurodegenerative diseases across the central nervous system, yet these strategies have been developed largely in young animals. Because aging is the primary risk factor for neurodegeneration, whether glia-to-neuron reprogramming remains effective in aged tissue is a critical unanswered question. Here, using the retina as an accessible part of the central nervous system, we show that aging is a major barrier to glia-t...
• HuB/HuR inhibition decreases HPV E6 and E7 proteins, stabilizes p53, and induces integrated stress to impair cervical cancer cell growth AI翻译
  作者：Liu, Xisheng; Shrestha, Saroj Kumar; Edwards, Yvonne J. K.; Filippova, Natalia; Landen, Charles N.; Buchsbaum, Donald J.; Nabors, Louis B.; Chow, Louise T.; Banerjee, N. Sanjib
  作者单位：University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Virginia; University of Alabama System; University of Alabama Birmingham
  摘要：High-risk human papillomaviruses (HR-HPVs) cause 95% of cervical cancers (CaCx) and a significant fraction of other anogenital and oropharyngeal cancers. Transcriptomic analyses have revealed that HR-HPVs differentially induce RNA binding proteins (RBPs) associated with cancer-related pathways. One of them, ELAVL2/HuB, is related to the ubiquitous, well-studied ELAVL1/HuR. But the role of either RBP in HPV pathobiology is unclear. In this study, we examined SRI-42127, an inhibitor of HuR, for ...
• A self-resetting soft ring for autonomous, continuous leaping in unstructured environments AI翻译
  作者：Qi, Fangjie; Zhou, Caizhi; Qing, Haitao; Sun, Haoze; Hong, Yaoye; Yin, Jie
  作者单位：North Carolina State University
  摘要：Continuous leaping is an effective locomotion strategy for traversing cluttered and unstructured environments. However, achieving autonomous continuous leaping in soft machines remains challenging because it requires recyclable energy storage and release, reliable self-resetting for relaunch, aerial stability, and adaptability across diverse terrains. Here, we report a self-resetting soft ring jumper capable of autonomous, continuous, and stable horizontal leaping under constant infrared illum...
• Auditory ecology of sound localization: Hunting bats maximize forward sensitivity at the expense of interaural location cues AI翻译
  作者：Traer, James A.
  作者单位：University of Iowa
• Insights into Neanderthal development, childbirth, and locomotion from the Palomas and Dederiyeh pelves AI翻译
  作者：Zollikofer, Christoph P. E.; Ponce de Leon, Marcia S.; Uriarte, Maria Haber; Lopez, Mariano V.; Ortega, Jon; Kondo, Osamu; Akazawa, Takeru; Walker, Michael J.
  作者单位：University of Zurich; Institute for Basic Science - Korea (IBS); University of Tokyo; Kochi University Technology
  摘要：The human pelvis reflects evolutionary compromises among childbirth, bipedal locomotion, and other factors such as pelvic floor stability and thermoregulation. However, limited fossil evidence has hindered understanding of how these factors shaped pelvic morphology in Neanderthals, our closest extinct relatives. Here, we present new virtual reconstructions and morphometric analyses of nearly complete Neanderthal pelves from Sima de las Palomas del Cabezo Gordo (Spain) and Dederiyeh Cave (Syria...
• SET7-mediated methylation of IRF3 at lysine 98 attenuates antiviral innate immunity AI翻译
  作者：Deng, Hongyan; Sun, Xueyi; Zha, Huangyuan; Wang, Zixuan; Tang, Jinhua; Chen, Xiaoyun; Zhu, Chunchun; Hua, Jiale; Liu, Wen; Jia, Shuke; Luo, Yiman; Xiang, Yuhan; Li, Wenhua; Liu, Xing; Xiao, Wuhan
  作者单位：Chinese Academy of Sciences; Institute of Hydrobiology, CAS; Hubei Hongshan Laboratory; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Wuhan University
  摘要：SET7 belongs to the SET domain (SETD) methyltransferase family, which catalyzes the monomethylation of lysine residues in histones and nonhistone proteins. This process can either enhance or suppress gene activation. Interferon regulatory factor 3 (IRF3) is a key transcription factor in the type I interferon (IFN) signaling pathway. This pathway is controlled by multiple posttranslational modifications that finely tune IRF3's function. Here, we identify SET7 as a negative regulator of IRF3. SE...
• RNF213-dependent lytic destruction of Chlamydia-containing vacuoles activates host cell death pathways AI翻译
  作者：Dickinson, Mary S.; Walsh, Stephen C.; Bastidas, Robert J.; Valdivia, Raphael H.; Coers, Jorn
  作者单位：Duke University; Duke University
  摘要：The cytokine gamma-interferon promotes antimicrobial cell-autonomous immunity by inducing hundreds of interferon-stimulated genes (ISGs). Among these ISGs is the ubiquitin E3 ligase RNF213 which protects host cells from a wide range of intracellular pathogens including the obligate intracellular bacterium Chlamydia. The human pathogen Chlamydia trachomatis normally employs its secreted virulence effector GarD to evade RNF213-mediated killing. However, in the absence of GarD, RNF213 is recruite...
• Structural basis of GSDME pore formation and its regulation by S-palmitoylation AI翻译
  作者：Du, Gang; Ehrmann, Julian F.; Lieberman, Judy; Wu, Hao
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard University; Harvard Medical School
  摘要：Pyroptosis is defined as gasdermin-mediated lytic programmed cell death. Gasdermin E (GSDME), a substrate of the apoptotic caspase-3, can convert apoptosis into pyroptosis, with critical roles in antitumor immunity and chemotherapy-induced tissue damage. Despite its importance, the structural mechanism of GSDME pore formation and its regulation by posttranslational modifications remain largely unknown. Here, we present the cryo-electron microscopy (cryo-EM) structure at 3.16 & Aring; resolutio...
• WNK-dependent phosphorylation of gephyrin tunes GABAA receptors at inhibitory synapses and modulates anxiety behavior AI翻译
  作者：Merlaud, Zaha; Delhaye, Celia; Nabais, Margarida; Pol, Erwan; Lima, Tania; Verdier, Yann; Imani, Zahra; Russeau, Marion; Samba, Nalia; Tostain, Maelys; Gouhier, Juliette; Rahir, Romane; Vinh, Joelle; Le Magueresse, Corentin; Nosten-Bertrand, Marika; Levi, Sabine
  作者单位：Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS)
  摘要：The role of the chloride-sensitive kinase WNK1 and its effector SPAK in the brain remains poorly understood. Here, we identify a WNK-dependent regulatory mechanism that directly controls the synaptic diffusion and clustering of inhibitory GABAA receptors (GABAARs), as well as their membrane stability and endocytosis. We show that activation of WNK signaling stabilizes GABAARs at inhibitory synapses, while inhibition enhances receptor internalization. This regulation depends on the phosphorylat...