35期

最新文章

• Plasmodium thiamine pyrophosphokinase is essential for sporozoite formation and activation of an antiplasmodial thiamine analogue AI翻译
  作者：Fathoni, Imam; Kina, Umit Y.; Chan, Alex H. Y.; Lee, Jiwon; Ho, Terence C. S.; Rauch, Manuel; Martin, Peer; Meissner, Emily A.; Stach, Thomas; Leeper, Finian J.; Rug, Melanie; Matuschewski, Kai; Saliba, Kevin J.
  作者单位：Australian National University; Humboldt University of Berlin; University of Cambridge; Australian National University; Adelaide University; University of Adelaide
  摘要：Oxythiamine, a thiamine analogue, inhibits Plasmodium falciparum proliferation by acting as an antimetabolite of vitamin B1. To elucidate in more detail its underlying mechanism of action, in vitro drug pressure was employed to generate oxythiamine-resistant P. falciparum lines. Whole-genome sequencing revealed that resistance was conferred by a single-point mutation in the thiamine pyrophosphokinase (TPK) gene. The mutated TPK has reduced activity, thereby likely limiting the conversion of ox...
• Interactive representations of power and status signals in learning social hierarchies AI翻译
  作者：Feng, Chunliang; Liu, Feilong; Yang, Binjie; Derrington, Edmund; Luo, Yuejia; Qu, Chen; Dreher, Jean-Claude
  作者单位：South China Normal University; South China Normal University; South China Normal University; South China Normal University; South China Normal University; Centre National de la Recherche Scientifique (CNRS); Universite Lyon 1; Beijing Normal University; University of Health & Rehabilitation Sciences; Shenzhen University
  摘要：Social hierarchies, which organize our social relationships, have heterogeneous effects on choice behavior. Two central dimensions of social hierarchies, status, which is earned through recognition of competence, and power, which is the capacity to control the outcomes of others, may contribute to different behavioral profiles. Yet, the neurocomputational processes by which status- and power-related signals are learned based on social feedback, and influence subsequent decision-making, remain ...
• YBX1 regulates RNA polymerase III transcripts to prevent inflammation AI翻译
  作者：Strilets, Tania I.; Dremel, Sarah E.; Garcia-Blanco, Mariano A.
  作者单位：University of Texas System; University of Texas Medical Branch Galveston; University of Virginia; University of Virginia
  摘要：Tolerance of endogenous nucleic acids is crucial for cellular homeostasis and when perturbed can lead to immune dysregulation. RNA-binding proteins (RBPs) bind, modify, and compartmentalize endogenous RNAs to prevent their recognition by the innate immune system. We found that loss of a highly abundant RBP, the cold shock domain containing Y-box binding protein 1 (YBX1), results in the spontaneous induction of an IL6/STAT3 inflammatory response and the upregulation of interferon-stimulated gen...
• Inner ear deficits complicate interpretation of depression-like behaviors in Gpr156 mutant mice AI翻译
  作者：Tarchini, Basile; Eatock, Ruth Anne; Kindt, Katie S.; Orlandi, Cesare; Cullen, Kathleen E.
  作者单位：Jackson Laboratory; University of Chicago; National Institutes of Health (NIH) - USA; University of Rochester; Johns Hopkins University
• Multilevel sex-influenced neurobiological signatures of early life adversity AI翻译
  作者：Narayan, Sowmya; Beer, Christina; Kovarova, Veronika; Castoldi, Carlo; Stark, Tibor; Bianco, Beatrice Dal; Roh, Simone; Sauer, Susann; Bordes, Joeri; Karamihalev, Stoyo; Mitra, Shiladitya; Miguel, Patricia Maidana; Alberry, Bonnie; Czamara, Darina; Silveira, Patricia P.; Czisch, Michael; Silva, Bianca; Binder, Elisabeth B.; Schmidt, Mathias V.
  作者单位：Max Planck Society; Max Planck Society; Centre National de la Recherche Scientifique (CNRS); Universite Cote d'Azur; CNRS - National Institute for Biology (INSB); Max Planck Society; Max Planck Society
  摘要：Stress exposure early in life is an established risk factor for adult psychiatric illness, yet these disorders-including anxiety disorders and depression-show significant sex differences in prevalence, symptomatology, and treatment response. The biology underlying these differences remains largely unexplored and may contribute to the clinical heterogeneity in anxiety and depression. Here, we characterize the lasting impact of developmental stress on adulthood neurobiology and behavior in mice ...
• The rod bipolar cell pathway contributes to surround responses in OFF retinal ganglion cells AI翻译
  作者：Spampinato, Giulia; Trapani, Francesco; Calbiague-Garcia, Victor; Buffet, Thomas; Orendorff, Elaine; Sermet, B. Semihcan; Glaziou, Guilhem; Dalkara, Deniz; Ronzitti, Emiliano; Papagiakoumou, Eirini; Emiliani, Valentina; Marre, Olivier
  作者单位：Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Fondation Adolphe de Rothschild
  摘要：Sensory neurons can be influenced by stimuli beyond their receptive field center, yet the mechanisms underlying this surround modulation remain poorly understood. In the retina, many OFF ganglion cells exhibit responses to ON stimulation outside their receptive field center. However, disentangling the pathways and cell types contributing to these responses has been challenging with traditional experimental approaches. Here, we combined optogenetics, two-photon holographic stimulation, and mult...
• Co-option of ancestral stem regulators drove recurrent evolution of underground storage organs AI翻译
  作者：Brose, Julia; Martin, Dionne; Wang, Yi-Wen; Wood, Joshua C.; Vaillancourt, Brieanne; Hamilton, John P.; Mailloux, Kathrine; Edger, Patrick P.; Buell, C. Robin
  作者单位：University System of Georgia; University of Georgia; Michigan State University; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; Michigan State University; University System of Georgia; University of Georgia
  摘要：Geophytes are plants that produce underground storage organs such as tubers, rhizomes, and bulbs, to facilitate asexual reproduction and withstand a myriad of environmental challenges. While the potato (Solanum tuberosum L.) serves as the primary model for studying tuberization, the genetic mechanisms encoding this trait across diverse angiosperm lineages remains unclear. This study utilized a phylogenomic-transcriptomic approach to compare tuber development across nine tuberizing species with...
• HLA class I escape drives the evolution of SARS-CoV-2 in human populations AI翻译
  作者：Riumina, Ekaterina D.; Alekseeva, Evgeniia I.; Klink, Galya V.; Feigin, Stepan; Vinogradova, Iaroslava; Ivanova, Natalia; Dianov, Dmitry; Zornikova, Ksenia; Davydova, Vassa; Bogolyubova, Apollinariya; Bazykin, Georgii A.
  作者单位：Lomonosov Moscow State University; Russian Academy of Sciences
  摘要：The role of escape from the cytotoxic T cell (CTL) response in Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the human leukocyte antigen (HLA) class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of concern, and 39% of all subsequent viral mutations, facilitate escape of viral epi...
• Large-scale brain network reinstatement supports recognition memory AI翻译
  作者：Sheng, Jintao; Li, Junle; Zeng, Xiangli; Wang, Jinhui
  作者单位：Stanford University; Stanford University; Stanford University; South China Normal University; South China Normal University; South China Normal University; South China Normal University; South China Normal University
  摘要：Remembering past experiences requires the reinstatement of neural activity patterns, yet whether and how this process unfolds across large-scale brain networks remains unclear. Here, we developed an approach to construct dynamic large-scale brain networks from trial-wise activation maps in the Natural Scenes Dataset. We identified robust network-level item-specific representations at whole-brain, subsystem, and regional scales. Network-level reinstatement, particularly for connections involvin...
• Enterochromaffin cells as a cellular integration hub for cooperative microbial signaling to modulate gut serotonin and motility AI翻译
  作者：Xiao, Yang; Louwies, Tijs; Mars, Ruben A. T.; Till, Lisa M.; Gupta, Yash; Mercado-Perez, Arnaldo; Bhagwate, Aditya V.; Bellampalli, Shreya S.; Stark Quiroz, Alejandro; Sekhon, Prabhjot K.; Singh, Vaidhvi; Liu, Rongfang; Heitman, Laura H.; Tienter, Dennis; Thompson, Michael A.; Kossick, Kimberlee F.; Krueger, Eugene W.; Kalari, Krishna R.; Hawkins, Kaitlyn R.; Lee, Jeong-Heon; Edwards, Brian S.; van der Es, Daan; Alcaino, Constanza; Willett, Julia L. E.; Wongkrasant, Preedajit; Guo, Chun-Jun; Prakash, Y. S.; Druliner, Brooke R.; Ordog, Tamas; Farrugia, Gianrico; Beyder, Arthur; Smith-Edwards, Kristen M.; Kashyap, Purna C.
  作者单位：Mayo Clinic; Mayo Clinic; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Minnesota System; University of Minnesota Twin Cities; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine
  摘要：The intestinal epithelium is exposed to diverse combinations of microbiota-derived compounds; however, the mechanisms by which the host integrates these signals remain poorly defined. Studying two highly abundant microbial metabolites, we identified the purine metabolite hypoxanthine as an effector metabolite that directly drives signaling and the short-chain fatty acid butyrate as a regulatory metabolite that conditions host responsiveness. Specifically, hypoxanthine activates the adenosine A...