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作者：Fineberg, Harvey V.
作者单位：Harvard University; Harvard T.H. Chan School of Public Health
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作者：Kamat, Varun; Grumbine, Matthew K.; Bao, Khang; Tsumura, Lui; Lim, Rayne; Wang, Shari; Hermansson, James; Kramlich, John; den Hartigh, Laura J.; Chao, Jennifer R.; Hurley, James B.; Sweet, Ian R.
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Vascular endothelial growth factor-A (VEGF) is a critical determinant of retinopathy due to vascular complications. Its expression is chronically regulated by transcription factors notably hypoxia-inducible factor-1 alpha (HIF-1 alpha) in response to decreased availability of oxygen [O2]. We considered whether there is a distinct rapid response component of VEGF secretion in response to low O2, faster than could be achieved by HIF-1 alpha. To investigate this possibility, we measured real time...
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作者：Chongloi, Grace Lhaineikim; Meir, Zohar; Amsellem, Ziva; Aviezer, Iris; Ben-Kiki, Oren; Mukamel, Zohar; Wahl, Vanessa; Eshed, Yuval
作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; James Hutton Institute; Austrian Academy of Sciences; Vienna Biocenter (VBC); Gregor Mendel Institute of Molecular Plant Biology (GMI)
摘要：Shoot branching patterns and their diversity arise from variable activities of axillary meristems (AMs). A common feature of flowering plants is delayed AM initiation and growth during the vegetative phase, followed by a sudden and rapid acceleration of apical AM initiation during the reproductive phase. The mechanisms underlying this pronounced developmental shift are poorly understood. During tomato floral transition, the primary shoot meristem (PSM) terminates in a flower after producing tw...
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作者：Liu, Qianghui; Chen, Peiran; He, Chunyan; Qiu, Zuocheng; Zhang, Yubo; Wang, Jia; Xu, Lingxiao; Xu, Yong; Pan, Mingyu
作者单位：Nanjing Medical University; City University of Hong Kong; Jinan University; Jinan University; Jinan University; Nanjing Medical University; Nanjing Medical University
摘要：RNA viruses, major pathogens of humans and animals, are responsible for numerous inflammatory diseases. Commonly, mild RNA virus infection fails to trigger inflammatory diseases due to host immune homeostasis. However, severe RNA virus infection destroys immune homeostasis and causes hyperinflammation. The detail mechanism is still unclear. Here, we reported that SESN1 acts as a critical negative regulator of mitochondrial antiviral signaling protein (MAVS), a central hub protein in RNA-trigge...
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作者：Nemati, Hossein; Suijkerbuijk, Saskia Jacoba Elisabeth; de Graaf, Joost
作者单位：Utrecht University; Utrecht University
摘要：Cell competition in multicellular organisms has been shown to play a critical role during the development of organisms, cancer progression, and in the establishment and maintenance of tissue homeostasis. Various mechanisms of cell competition have been identified, including active elimination via mechanical forces or induced apoptosis, as well as competition for nutrients and other beneficial factors. A recent experiment demonstrated hallmarks of cell competition, associated with cell cycle dy...
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作者：Panfoli, Isabella; Candiano, Giovanni; Bruschi, Maurizio
作者单位：University of Genoa; University of Genoa; IRCCS Istituto Giannina Gaslini; University of Genoa
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作者：Johnson, Catherine L.; Plattner, Alain M.; Cicchetti, Filippo; Miljkovic, Katarina
作者单位：University of British Columbia; University of Alabama System; University of Alabama Tuscaloosa; Curtin University
摘要：Mercury is the only planet other than Earth to possess both a global magnetic field that arises from a core dynamo, and a crustal magnetic field that arises from magnetized rocks. Crustal fields provide unique records of a planet's interior state and evolution because magnetizations depend on the magnetizing field and the magnetic minerals present. A major unresolved issue for Mercury is the relative contributions of present-day (induced) and ancient (remanent) magnetizations-both are expected...
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作者：Narrett, Isaac S.; Weiss, Benjamin P.; Steele, Sarah C.; Biersteker, John B.
作者单位：Massachusetts Institute of Technology (MIT); Harvard University
摘要：Mercury is the only terrestrial planet in the solar system other than Earth with an active dynamo magnetic field (similar to 200 nT at the equatorial surface). Furthermore, Mercury's similar to 3.9-to 3.7-billion-year-old (Ga) crust is strongly magnetized (similar to 10 nT at similar to 30-km altitude), indicating the presence of a past dynamo. However, the strength of the past dynamo field and the mechanism that generated it are unknown. To address this, we performed three-dimensional magneto...
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作者：Nickodem, Colette A.; Tran, Patricia Q.; Neeno-Eckwall, Eric; Naing, Naing; Sanford, Gregg R.; Silva, Erin M.; Hite, Jessica L.
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：Agricultural soils are critical hotspots of antimicrobial resistance genes (ARGs). Yet, the environmental factors shaping these reservoirs and the hazards they pose to humans and livestock remain poorly understood. Because management practices introduce antibiotics, heavy metals, and nonantibiotic biocides, they can rapidly select for resistance. Most studies have examined components of management practices in isolation, overlooking the multiple stressors of modern industrial agriculture. Here...
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作者：Ravindran, Sandeep
