35期

最新文章

• Cerebellar microcircuits enable robust evidence-based decisions through cortico-cerebellar coupling AI翻译
  作者：Bao, Yeyao; Yu, Liao; Lu, Liangfu; Yang, Zhuoqin; Zang, Yunliang
  作者单位：Tianjin University; Tianjin University; Beihang University
  摘要：The cerebellum is increasingly implicated in perceptual decision-making, yet it remains unclear how the cerebellar cortex can support sparse evidence accumulation over behavioral time scales without assuming cortical-style dense local excitatory recurrence. We present a biologically constrained modeling framework showing that cerebellar microcircuits can implement graded accumulation and competition in the absence of such recurrence. In our model, type-II Purkinje-neuron excitability generates...
• Synthetic DNA fragments as ultra-high-resolution multitracers to quantify transport behavior of micro- and nanoplastics in plant systems AI翻译
  作者：Duan, Zhaofei; Wang, Changxi; Liao, Renkuan; Liao, Yanling; Li, Xinlin; Shen, Chongyang; Xiong, Yunwu; Yang, Dayong; Simunek, Jirka; Luo, Dan
  作者单位：China Agricultural University; China Agricultural University; Fudan University; University of California System; University of California Riverside; Cornell University
  摘要：Although plant uptake of micro- and nanoplastics (MNPs) has been well documented, accurately identifying MNP sources and tracking their transport within plants remain major challenges, primarily due to the lack of effective multisource tracing technologies. To fill this gap, we established an ultra-high-resolution multisource tracing approach by encapsulating sequence-specific synthetic DNA fragments into MNPs, followed by quantification of their transport using quantitative real-time PCR (qPC...
• Bright monomeric fluorescent protein elite-niRFP704 for two-channel near-infrared STED nanoscopy AI翻译
  作者：Habenstein, Florian; Jensen, Nickels; Stumpf, Daniel; Chizhik, Alexey I.; Leutenegger, Marcel; Chang, Jin; Fognini, Andreas; Qin-Dregely, Jessie; Zadeh, Iman Esmaeil; Kirck, Laura L.; Enderlein, Jorg; Inamdar, Kaushik; Hell, Stefan W.; Jakobs, Stefan
  作者单位：University of Gottingen; Delft University of Technology; University of Gottingen; University of Gottingen; Max Planck Society
  摘要：The near-infrared (NIR) spectral region is attractive for live-cell imaging, due to low autofluorescence and reduced phototoxicity. Some phytochrome-derived fluorescent proteins absorb and emit fluorescence in the NIR, but have short fluorescence lifetimes and relatively low quantum yields, requiring higher laser powers thus limiting their usefulness for live-cell superresolution microscopy. Using the bacterial phytochrome miRFP703 as a template, we screened for variants with longer fluorescen...
• Mechanisms behind facilitation-competition transition along rainfall gradients AI翻译
  作者：Hollander, Oded; Mau, Yair; DeMalach, Niv
  作者单位：Hebrew University of Jerusalem; Hebrew University of Jerusalem
  摘要：Woody cover is rapidly changing due to mortality, shrub encroachment, and afforestation, reshaping herbaceous communities and ecosystem functioning worldwide. Trees and shrubs often facilitate herb growth in dry sites but suppress it in wetter environments. Explanations for this facilitation-to-competition transition lack a clear link to resource competition theory, despite being a fundamental aspect of the broader Stress Gradient Hypothesis. While recent quantitative frameworks exist, explana...
• Lysophospholipid-TRPV1 interactions in chemotherapy-induced neuropathy AI翻译
  作者：Wedel, Saskia; Cabezudo, Ainara Claveras; Rauh, Oliver; Olkhova, Elena; Mueller, Christian; Hahnefeld, Lisa; Gurke, Robert; Geisslinger, Gerd; Hummer, Gerhard; Sisignano, Marco
  作者单位：Goethe University Frankfurt; Max Planck Society; Hochschule Bonn Rhein Sieg; Goethe University Frankfurt
  摘要：Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting side effect of first-line chemotherapeutics such as paclitaxel, for which effective treatments are currently unavailable. We found that plasma collected 24 h after paclitaxel administration enhanced sensory neuron activation. To identify potential mediators of this effect, we applied a broad LC-HRMS-based lipidomics approach to quantify plasma lipids in breast cancer patients before and 24 h after treatment. We obs...
• A kinematic convergence in ape and monkey vertical climbing informs debates on early hominin arborealism AI翻译
  作者：Fannin, Luke D.; Pape, Carmen; McGraw, W. Scott
  作者单位：Dartmouth College; University of St Andrews; University System of Ohio; Ohio State University
  摘要：Recent debates on early hominin arborealism center around interpretations of fossilized foot bones as being either African ape- or monkey- like in their morphology. These dueling interpretations fuel competing locomotor reconstructions of the last common ancestor of chimpanzees and humans (LCA), including disagreements about the prevalence of vertical climbing behaviors. Yet it remains unclear if possessing an ape- or monkey-like foot impacts the safety and efficiency of climbing, in part beca...
• Hidden global diversity and sampling gaps in Orthoptera insects revealed through distribution data AI翻译
  作者：Scattolini, M. Celeste; Lira-Noriega, Andres; Pocco, Martina E.; Pereira, Hernan L.; Cabrera, Maria Belen; Cigliano, Maria Marta
  作者单位：Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); National University of La Plata; Museo La Plata; Instituto de Ecologia - Mexico
  摘要：Insects are essential to terrestrial ecosystems but remain underrepresented in global biodiversity assessments. This macroecological study presents a global analysis of diversity patterns in Orthoptera (grasshoppers, locusts, crickets, and katydids), using over 830,000 georeferenced records, species distribution models, and environmental data. The analysis revealed hotspots of diversity and endemism in tropical and subtropical regions of Asia, South America, and Africa. Biome-level comparisons...
• Reply to Panfoli et al.: From O2 consumption in myelin to gap junctional ATP delivery in axons: An energy link needing further scrutiny AI翻译
  作者：Witschas, Katja; Ghysels, An; Leybaert, Luc
  作者单位：Tampere University; Ghent University; Ghent University
• Calbindin stratifies midbrain dopaminergic neurons governing distinct aspects of locomotion AI翻译
  作者：Bolduc, Cyril; Oram, Cameron; Donovan, Skylar; Bach, Haleigh; Liu, Martha; Marier, Rafaelle; Sharpe, Morgan; Liu, Siqi; Campeau, Cedric; Spencer, Carl Duncan; Martin, Sarah A.; Awatramani, Rajeshwar; Poulin, Jean-Francois
  作者单位：McGill University; Northwestern University; Feinberg School of Medicine
  摘要：Despite advances in delineating the molecular diversity and projection patterns of midbrain dopamine (DA) neurons, subtype-specific contributions to motor learning and movement execution remain poorly defined. Here, we applied intersectional ablation and inhibitory chemogenetics to dissect the roles of calbindin-expressing (CALB1+) and nonexpressing (CALB1-) DA neurons in locomotion. Using newly engineered intersectional autocleavable Caspase3 constructs, we ablated CALB1+ or CALB1- DA neurons...
• A dominant mutation in tomato DNA POLYMERASE DELTA 1 causes geminivirus DNA replication catastrophe AI翻译
  作者：Gustian, Deri; Yu, Chen-Hsin; Jan, Fuh-Jyh; Gruissem, Wilhelm
  作者单位：National Chung Hsing University; Academia Sinica - Taiwan; National Chung Hsing University
  摘要：Geminiviruses pose a severe threat to grain and vegetable crops worldwide, often resulting in significant economic losses. In cultivated tomato (Solanum lycopersicum), Ty resistance alleles have been introduced from wild tomato relatives, providing partial to strong resistance to geminivirus infections. The Ty-6 resistance locus from Solanum chilense was previously mapped to chromosome 10. It was recently shown to contain a mutant allele of the DNA POLYMERASE DELTA 1 (POLD1) gene that provides...