35期

最新文章

• Structural insights into fosfomycin efflux by a streptococcal ABC transporter AI翻译
  作者：Taguchi, Atsushi; Fujita, Junso; Tanabe, Mikio; Takaya, Daisuke; Harada, Kazuo; Moriya, Toshio; Fukuzawa, Kaori; Namba, Keiichi; Nishino, Kunihiko
  作者单位：University of Osaka; University of Osaka; University of Osaka; University of Osaka; University of Osaka; High Energy Accelerator Research Organization (KEK)
  摘要：Gram-positive bacteria encode a broad array of ABC transporters that mediate substrate translocation across the cell membrane, with some contributing to their survival under environmental stresses such as antimicrobial exposure. While several of these transporters have been shown to exhibit multidrug efflux activity, the functional roles of many others remain unknown. Here, using an efflux pump screen in the opportunistic human pathogen Streptococcus pneumoniae, we identified a previously unch...
• Reconciling strange metal transport in CeCoIn5 through the difference of optical and cyclotron effective masses AI翻译
  作者：Wang, Jingyuan; Tagay, Zhenisbek; Shi, Liyu; Liang, Jiahao; Duong, Nghiep Khoan; Wu, Yi; Vianez, Pedro Manuel Trocado; Ronning, Filip; Rickel, Dwight G.; Schlom, Darrell G.; Shen, Kyle M.; Crooker, Scott A.; Armitage, N. P.
  作者单位：United States Department of Energy (DOE); Los Alamos National Laboratory; Johns Hopkins University; Cornell University; United States Department of Energy (DOE); Los Alamos National Laboratory; Cornell University; Leibniz Association; Leibniz Institut fur Kristallzuchtung (IKZ); Canadian Institute for Advanced Research (CIFAR)
  摘要：The strange metal behavior in cuprate superconductors-characterized by linear in temperature resistivity and anomalous Hall transport-stands in stark contrast to the expectation of conventional Fermi liquid (FL) theory. Remarkably, the similar transport behavior has also been observed in the heavy fermion metal CeCoIn5, whose d-wave superconducting ground state and strong antiferromagnetic fluctuations draw parallels to the cuprates. Here we have investigated the optical conductivity of the st...
• Quantitative nanoscale imaging shows peptide-MHC I complexes are monomeric and spatially regulated in human dendritic cells AI翻译
  作者：Jacobs, Olivia; Menche, Tanja; Hoper, Cindy; Gerhards, Frederic; Fucek, Ivica; Vascotto, Fulvia; Dietz, Marina S.; Heilemann, Mike; Tampe, Robert
  作者单位：Goethe University Frankfurt; Goethe University Frankfurt; Johannes Gutenberg University of Mainz; Goethe University Frankfurt
  摘要：Major histocompatibility complex class I (MHC I) molecules present antigenic peptides to cytotoxic T cells, a process central to immune surveillance. However, the nanoscale spatial organization of peptide-MHC I (pMHC I) on human dendritic cells (DCs), key initiators of cytotoxic T cell responses, remains largely unexplored. Here, we combine high-affinity soluble T cell receptors with DNA-based point accumulation for imaging in nanoscale topography (DNA-PAINT) to quantitatively map and count de...
• Uncovering dynamic human brain phase coherence networks AI翻译
  作者：Olsen, Anders S.; Brammer, Anders; Fisher, Patrick M.; Morup, Morten
  作者单位：Technical University of Denmark; University of Copenhagen; Rigshospitalet; Copenhagen University Hospital; University of Copenhagen
  摘要：Complex cognitive functions rely on coordinated communication between distributed brain regions, yet capturing these interactions as they evolve over time remains challenging. Traditional analyses of functional brain connectivity largely rely on correlations in signal amplitude, which are sensitive to noise and artifacts such as head motion. Here, we introduce a mixture modeling approach that focuses on the phase of brain signals, allowing dynamic patterns of large-scale synchronization in bra...
• Advances in small area population estimation in the absence of national census data AI翻译
  作者：Tatem, Andrew J.; Boo, Gianluca; Chamberlain, Heather R.; Nnanatu, Christopher C.; Darin, Edith; Leasure, Douglas R.; Yankey, Ortis; Gadiaga, Assane; Juran, Sabrina; Rodriguez, Luis de la Rua; Espey, Jessica; Lazar, Attila N.
  作者单位：University of Southampton; University of Oxford; United Nations Population Fund
  摘要：Population data at small area scales are essential for effective decision-making, influencing public health, disaster response, and resource allocation, among others. While national censuses remain the cornerstone of population data, they are often constrained by high costs, infrequent collection cycles, and coverage gaps, which can hinder timely data availability. To address these challenges, geospatial statistical approaches using limited microcensus surveys have been demonstrated as a relia...
• Reshaping pathogen ecology in the Anthropocene AI翻译
  作者：Hoskisson, Paul A.
  作者单位：University of Strathclyde
• Structural evolution beyond carbon fullerenes: A family of metal-oxo clusters AI翻译
  作者：Zhang, Di; Zhao, Xiao-Kun; Duan, Feng-Xue; Lei, Peng; Zhen, Ni; Xu, Cong-Qiao; Chi, Yingnan; Lan, Ya-Qian; Li, Jun; Hu, Changwen
  作者单位：Beijing Institute of Technology; Qingdao University; Chinese Academy of Sciences; Ganjiang Innovation Academy, CAS; Southern University of Science & Technology; Southern University of Science & Technology; South China Normal University; Tsinghua University; Tsinghua University
  摘要：Fullerenes are a unique class of stable molecular clusters whose structural evolution is constrained by the geometry and topology of pentagon-hexagon arrangements of sp2-hybridized carbons with (p-p)pi conjugation. However, extending this geometry- and topology-driven structural evolution to other inorganic systems remains exceedingly rare, because it is highly challenging to achieve controlled assembly of distinct building units and precisely tune their numbers. Here, we report a family of me...
• Loss of epitranscriptomic mitochondrial RNA surveillance drives epithelial type I interferon and inflammation in autoimmunity AI翻译
  作者：Arco-Hierves, Alejandro; Pamboukas, Konstantina; Bilonda Mutala, Linda; Borowski, Lukasz S.; Mayet, Celine; Mazet, Paul; Silva-Saffar, Sacha E.; Vergallo, Dory; Paszek, Anna; Dilling, Marta M.; Askenatzis, Laurie; Pascaud, Juliette; Labrot, Philippe; Lasgi, Charlene; Spelbrink, Johannes N.; Navickas, Albertas; Naninck, Thibaut; Seddiki, Nabila; Tete, Arnaud; Szczesny, Roman J.; Nocturne, Gaetane; Mariette, Xavier; Bechara, Rami
  作者单位：University of Warsaw; Polish Academy of Sciences; Institute of Biochemistry & Biophysics - Polish Academy of Sciences; Universite Paris Saclay; Radboud University Nijmegen; Radboud University Nijmegen; Centre National de la Recherche Scientifique (CNRS); Nantes Universite; CHU de Nantes; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); UNICANCER; Universite PSL; CNRS - National Institute for Biology (INSB); Institut Curie; University of New South Wales Sydney; Kirby Institute; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Bicetre - APHP
  摘要：Chronic interferon (IFN) activation is a hallmark of autoimmune diseases such as systemic lupus erythematosus and Sj & ouml;gren's disease (SjD), where epithelial cells are key contributors. Although viral and retroelement triggers have been proposed as triggers, direct evidence in patient tissues is limited, and endogenous mechanisms of epithelial IFN dysregulation remain unclear. Mitochondrial double-stranded RNA (mt-dsRNA) is a potent type I IFN (IFN-I) inducer, but its regulation in epithe...
• Indirect reciprocity with dual private assessment AI翻译
  作者：Tham, Yukari Jessica; Hilbe, Christian; Murase, Yohsuke
  作者单位：Kobe University; RIKEN; RIKEN; Saitama University
  摘要：People often cooperate out of concern for their reputation. The corresponding theory of indirect reciprocity predicts that such cooperation can only evolve if people's opinions of each other are sufficiently correlated. This correlation, however, can be difficult to achieve when individuals form their opinions independently from one another, as in private assessment models. In that case, errors can generate disagreements that propagate throughout a population. Here, we identify a simple mechan...
• ST6GAL1-mediated sialyl linkage switching drives cancer-promoting α2,6-sialo-protrusions radiating from anti-inflammatory TAMs AI翻译
  作者：Dipta, Priya; Bansal, Naaz; Chien, Arthur; Sumer-Bayraktar, Zeynep; Onizuka, Hironoshin; Kasugai, Daisuke; Marando, Dominique; Anugraham, Merrina; Ahn, Seong Beom; Kolarich, Daniel; Tirosh, Boaz; Kawahara, Rebeca; Everest-Dass, Arun; Thaysen-Andersen, Morten
  作者单位：Macquarie University; Hebrew University of Jerusalem; Nagoya University; Griffith University; Macquarie University; Griffith University; University System of Ohio; Case Western Reserve University
  摘要：Tumor-associated macrophages (TAMs) are functionally diverse effector cells in the tumor microenvironment (TME). Pro- and anti-inflammatory TAMs are central to cancer progression by shaping inflammation and immune homeostasis, but it remains unknown if polarization-induced remodeling of the TAM glycocalyx critical for cellular communication and interactions occurs within the TME. Taking a systems glycobiology approach, we first used cell surface-focused glycomics and lectin flow cytometry of e...