35期

最新文章

• SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation AI翻译
  作者：Hill, Kaeden K.; Barry, Ashley P.; Reinoso-Vizcaino, Nicolas M.; Haynes, Lauren E.; Bonglack, Emmanuela N.; Ferreira, Davis F.; Miller, Sara E.; Hirschey, Matthew D.; Chiang, Lillian W.; Remiszewski, Stacy; Luftig, Micah A.
  作者单位：Duke University; University of Cambridge; Duke University; Duke University; National University of Singapore
  摘要：Sirtuin-2 (SIRT2) is a cellular deacylase, regulating cell cycle progression and metabolic homeostasis. Recently, SIRT2 has emerged as a target with both anticancer and antiviral potential. However, the role and targetability of SIRT2 in viral-driven cancers remains unexplored. Epstein-Barr virus (EBV) is a ubiquitous herpesvirus with oncogenic potential that establishes latency in B lymphocytes and is typically controlled by a robust T cell immune response. In settings that compromise this re...
• Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals AI翻译
  作者：Mirsch, Johanna; Cordoni, Ratna N.; Schmitt, Cornelia; Dehnert, Melina I.; Schulze, Alicia; Galetzka, Danuta; Zahnreich, Sebastian; Scholz-Kreisel, Peter; Hankeln, Thomas; Marron, Manuela; Blettner, Maria; Ronckers, Cecile M.; Schmidberger, Heinz; Lobrich, Markus
  作者单位：Technical University of Darmstadt; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; Leibniz Association; Leibniz Institute for Prevention Research & Epidemiology (BIPS); Johannes Gutenberg University of Mainz
  摘要：DNA double-strand breaks (DSBs) which arise in G1- or G0-phase normal human cells are repaired by nonhomologous end-joining (NHEJ), a pathway which is important for cell survival but can cause mutations at the break sites. DSB repair by NHEJ is very efficient at high damage levels of 1 or more DSBs per cell, much less efficient at lower damage levels and almost absent if only similar to 0.05 DSBs per cell are induced. Here, we have analyzed the repair of high and low levels of radiation-induce...
• The role of chloride ions in serotonin transport AI翻译
  作者：Huang, Jiahui; Backer, Annika; Uchendu, Stacy; Bekele, Bethlehem; Li, Chan; Chen, Qingyang; Orabi, Esam A.; Stix, Robyn; Shide, Jasper D.; Zhang, Yuan-Wei; Rudnick, Gary; Hellsberg, Eva; Forrest, Lucy R.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); University of Vienna; Yale University; Guangzhou University; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
  摘要：The human serotonin (5-HT+) transporter SERT facilitates 5-HT+ transport into cells by coupling it to Na+ symport and K+ antiport. Although extracellular Cl- is also essential for transport, Cl- cotransport has been disputed, raising questions about the role of Cl- ions and why they are required. We show that Cl- gradients do not impact 5-HT+ accumulation, indicating that Cl- does not provide a driving force for uptake and arguing against stoichiometric Cl- symport. The presence of Cl- had onl...
• Barcoded mutant library enables high-throughput functional genomics in a filamentous fungus AI翻译
  作者：Huberman, Lori B.; Villalobos-Escobedo, Jose M.; Skerker, Jeffrey M.; Shi, Ran; Rico-Ramirez, Adriana M.; Adams, Catharine A.; Arkin, Adam P.; Deutschbauer, Adam M.; Glass, N. Louise
  作者单位：Cornell University; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Tecnologico de Monterrey; University of California System; University of California Berkeley
  摘要：Advances in sequencing technology enabling rapid and inexpensive whole-genome sequencing highlight how few genes are functionally characterized. This problem is particularly acute in filamentous fungi, where even in the best studied organisms upward of half of genes are poorly characterized or unannotated. High-throughput tools to identify gene function exist for single-celled organisms, like yeast and bacteria. However, filamentous fungi present challenges to high-throughput gene characteriza...
• Pelagic food web realignment supports resilient larvae of Southern Bluefin Tuna in a warming ocean AI翻译
  作者：Landry, Michael R.; Laiz-Carrion, Raul; Malca, Estrella; Swalethorp, Rasmus; Decima, Moira; Quintanilla, Jose M.; Borrego-Santos, Ricardo; Davies, Claire H.; Kranz, Sven A.; Selph, Karen E.; Stukel, Michael R.; Die, David; Beckley, Lynnath E.; Muhling, Barbara A.; Shiroza, Akihiro; Kim, Lindsey E.; Cawley, Grace F.; Traboni, Claudia; Walsh, Kamran; Jivanjee, Alejandro; Matisons, Luke
  作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; University of Miami; Universidad de Malaga; Rice University; University of Hawaii System; University of Hawaii Manoa; State University System of Florida; Florida State University; Murdoch University; University of California System; University of California Santa Cruz; Japan Fisheries Research & Education Agency (FRA); Stazione Zoologica Anton Dohrn; University of New South Wales Sydney
  摘要：Many of the oceans' top predatory fishes at low to mid latitudes face an uncertain future as their vulnerable larvae deal with higher environmental temperature and reduced productivity associated with climate change. However, ocean ecosystem models that predict a general decline of zooplankton prey with warming and stratification hardly ever account for complexities in pelagic food webs that might make them resilient in providing food resources for larvae. We illustrate such complexities in co...
• Gut microbiome-metabolome interactions during varied low-carbohydrate food consumption AI翻译
  作者：Nearing, Jacob T.; Kuntz, Thomas; Perdomo, Veronica; Nickols, William A.; Branck, Tobyn; Bhosle, Amrisha; Badri, Dayakar V.; Huttenhower, Curtis; Jackson, Matthew; Thompson, Kelsey N.
  作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Colgate-Palmolive Company; Hill's Pet Nutrition, Inc.; Harvard University; Harvard T.H. Chan School of Public Health
  摘要：Low-carbohydrate (LC) foods have been associated with weight loss, insulin resistance, and reduced inflammation. Gut microbes may drive these effects by changing the host's immune and metabolic state, yet the optimal replacement strategies (e.g., protein vs. fat) and the biochemical impacts are still uncertain. Thus, we conducted a randomized cross-over study in canines (n = 35) using a high-carbohydrate food for 4 wk, followed by two 5-wk intervals of LC foods replacing carbohydrates with fat...
• Site-specific phosphorylation affects the structure and interactions of the Ycf1p R region AI翻译
  作者：Quail, Sarah E. S.; Bickers, Sarah C.; Tymczak, Agatha; Eid, Maya Michelle; Kanelis, Voula
  作者单位：University of Toronto; University of Toronto; University Toronto Mississauga; University of Toronto
  摘要：Many ATP-binding cassette (ABC) proteins function in active transport of solutes across biological membranes. At minimum, ABC proteins contain two repeats of a transmembrane domain (TMD) and a nucleotide binding domain (NBD). In many ABC proteins, the TMD-NBD halves are connected by an intrinsically disordered linker that regulates the activity of the ABC protein through phosphorylation. These regulatory (R) regions are often invisible or at low-resolution in cryo-EM maps. Thus, information ab...
• Stochasticity and probabilistic trajectory scoring are essential for data-driven closures of chaotic systems AI翻译
  作者：Brolly, Martin T.
  作者单位：Heriot Watt University; University of Edinburgh
  摘要：Coarse-grained models of chaotic systems neglect unresolved degrees of freedom, inducing structured model error that limits predictability and distorts long-term statistics. Typical data-driven closures are trained to minimize prediction error over a single time step, implicitly assuming Markovian dynamics and often failing to capture long-term behavior. Recent approaches instead optimize losses over finite trajectories. However, when such trajectory-based training is carried out with determin...
• Nociceptive sensitization and pain perception are dissociable in humans AI翻译
  作者：Cormie, Matthew A.; Mouseli, Pedram; Martini, Clizia; De Silva, Kavita; Lauric, Ioana; Khalil, Omar; Seminowicz, David A.; Moayedi, Massieh
  作者单位：University of Toronto; University of Toronto; Western University (University of Western Ontario); Krembil Research Institute; University of Toronto; University Health Network Toronto
  摘要：Although pain and nociception are conceptually distinct, whether nociceptive sensitization can occur without pain remains unknown. Here, we show that convergent innocuous thermal stimulation elicits primary mechanical and secondary hyperalgesia without pain perception. In a preregistered study, we compared thermal grill illusion (TGI) responders (n = 96) and nonresponders (n = 64) by quantifying primary mechanical and secondary hyperalgesia following thermal grill stimulation. In responders, w...
• Association between precentral gyrus morphology and modality-specific intentional communication in chimpanzees (Pan troglodytes) AI翻译
  作者：Foubet, Ophelie; Sun, Zhong Yi; Mangin, Jean-Francois; Sherwood, Chet C.; Hopkins, William D.
  作者单位：Centre National de la Recherche Scientifique (CNRS); George Washington University; George Washington University; University of Texas System; UTMD Anderson Cancer Center
  摘要：The precentral gyrus (preCG) is morphologically defined posteriorly by the central sulcus (CS) and anteriorly by the superior and inferior precentral sulci (preCS). Stimulation of the preCG along the dorsal-ventral plane elicits motor activation across the body in a topographic manner. In this study, we used postimage analyses to characterize the shape of the CS and preCS in a sample of 278 magnetic resonance image scans of chimpanzees. Using these data, we initially described the six most pro...