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作者：Abe, Chikara; Fujita, Shin-ichiro; Shiba, Dai; Tanaka, Kunihiko; Fujimoto, Chisato; Tokunaga, Shigeto; Iwasaki, Shinichi; Takahashi, Satoru; Muratani, Masafumi; Morita, Hironobu
作者单位：Gifu University; University of Fukui; University of Tsukuba; University of Tsukuba; Northwestern University; University of Tokyo; University of Tsukuba; University of Tsukuba
摘要：Long-duration exposure to microgravity disrupts human balance and spatial orientation, yet the molecular mechanisms underlying vestibular adaptation to spaceflight remain poorly understood. Here, we tested the hypothesis that the saccule, the primary gravity-sensing otolith organ, undergoes selective remodeling during spaceflight and contributes to transient postflight postural instability. Using a cross-species approach, we combined transcriptomic analysis of mouse otolith organs with physiol...
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作者：Bailey, Joe; Sukhachov, Pavlo; Baumgaertl, Korbinian; Finizio, Simone; Wintz, Sebastian; Dubs, Carsten; Raabe, Jorg; Grundler, Dirk; Balatsky, Alexander; Aeppli, Gabriel
作者单位：Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Royal Institute of Technology; Nordic Institute for Theoretical Physics; Stockholm University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Helmholtz Association; Helmholtz-Zentrum fuer Materialien und Energie GmbH (HZB); University of Connecticut; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia
摘要：Wavelike bosonic particles can accumulate in a single mode characterized by a particular wavelength, and such condensates are at the heart of phenomena such as superconductivity and superfluidity where usually a single complex number describes their state. If there are several flavors of excitations or particles, a vector containing several complex numbers can characterize multicomponent condensation, thus opening new possibilities for textures, dynamics, and devices. Thus far, multicomponent ...
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作者：Chen, Yu-Chi; Bollu, Vishnu Sravan; Kheirabadi, Sina; LaPenna, Kyle; Berg, Arthur; He, Pingnian; Schell, Todd D.; Sheikhi, Amir; Tabdanov, Erdem D.; Robertson, Gavin P.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health
摘要：Melanoma, particularly in its advanced forms, remains one of the most lethal skin cancers, with limited effective treatments for both common cutaneous subtypes and rarer variants such as acral melanoma. The effects of the extracellular matrix (ECM) and other cancer-cell extrinsic processes on melanoma development remain underexplored. This study identifies growth differentiation factor-15 (GDF-15) as a mechanosensing-regulated driver of melanoma pathogenesis across melanoma types. GDF-15 is sh...
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作者：Sharp, Zachary; Wostbrock, Jordan; Gargano, Anthony; Hare, Vincent; Johnson, Jessica; Cerling, Thure; Banerjee, Payal; Peshek, Catherine; Knutson, Cloe; Hartzell, Lauren; Cano, Erick; Stiles, Elena; Bassett, Kelley R.; Holland, Kira; Dowd, Michael H.; Sae-Lim, Jarunetr (Nadia); Dominguez, Teresa; Bryant, Dalton; Di Marcantonio, Eduardo; Wainwright, Jensen; Horsford, Maxwell; Botte, Paul; Gagnon, Catherine; Rudall, Paula J.; Ehleringer, James
作者单位：University of New Mexico; Yale University; University of Cape Town; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; University of California System; University of California Santa Cruz; University of Washington; University of Washington Seattle; Swedish University of Agricultural Sciences; University of Alberta; University of Hawaii System; University of Hawaii Manoa; University of California System; University of California Irvine; University of Alabama System; University of Alabama Tuscaloosa; Sapienza University Rome; University of Oregon; State University of New York (SUNY) System; University at Albany, SUNY; State University of New York (SUNY) College of Environmental Science & Forestry; Brown University; Texas A&M University System; Texas A&M University College Station; Royal Botanic Gardens, Kew
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作者：Cai, Yanjun; Cheng, Hai; Breitenbach, Sebastian F. M.; Shukurov, Nosir; Petrov, Maxim; Shukurov, Shukhrat; Lei, Jing; Yang, Yingjie; Xue, Gang; Ma, Le; Huang, Shouyi; Li, Ruoxin; He, Mei; Shi, Zhengguo; Li, Hanying; Ning, Youfeng; Jia, Xuexue; Hao, Yifei; Osinzev, Alexander; Edwards, R. Lawrence; An, Zhisheng
作者单位：Xi'an Jiaotong University; Chinese Academy of Sciences; Institute of Earth Environment, CAS; Yunnan Normal University; Northumbria University; University of Minnesota System; University of Minnesota Twin Cities
摘要：Water resources are crucial for the survival and development of human societies in arid Central Asia. However, our understanding of regional hydroclimate variability and moisture dynamics remains limited. Here, we present a precisely dated, high-resolution speleothem delta 18O record from caves in northern Uzbekistan that reconstructs changes in precipitation delta 18O over the last 47,000 years. During the glacial interval, relatively low speleothem delta 18O values align with precipitation i...
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作者：Huang, Dong'e; Dong, Junqing
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作者：Su, Yuming; Ye, Zi; Chen, Yuanyuan; Wu, Guoyi; Zhang, Yue; Liu, Wangjun; Luo, Ting; Jiang, Jialiang; Zhang, Kaka
作者单位：Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Institute of Organic Chemistry, CAS; Chinese Academy of Sciences
摘要：We pioneered a strategy based on low-frequency vibronic coupling to design narrowband room-temperature phosphorescent (RTP) materials. Here we select coronene derivative (CoDe) system and report that attaching aroyl group to the coronene core disrupts its intrinsic symmetry and introduces abundant low-frequency vibrational modes, thereby affording efficient room-temperature phosphorescence with a full width at half maximum (FWHM) of approximately 25 nm or narrower. In CoDe systems functionaliz...
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作者：Wang, Jing; Ni, Zegui; Zhang, Xinxin; He, Linling; Zhang, Xinyue; Cheng, Xu; Wang, Haimo; Sun, Guoying; Lu, Zhenwei; Liu, Chengxu; Qian, Hongjie; Lu, Youli; Liu, Gangyi; Jia, Jingying; Ye, Jian; Huang, Linzhang; Ye, Haobin; Li, Rong; Tao, Wufan; Li, Peng; Zhao, Tong-Jin; Du, Xingrong
作者单位：Fudan University; City of Hope; Fudan University; Fudan University; Fudan University; Shanghai Qi Zhi Institute; Zhengzhou University
摘要：Amino acid sufficiency is critical for T cell metabolic reprogramming, yet how T cells maintain amino acid homeostasis remains poorly defined. Here, we identify the CORVET and HOPS (CORVET/HOPS) tethering complexes as essential upstream regulators. In activated T cells, they sustain intracellular amino acid levels by promoting macropinocytosis to acquire extracellular nutrients. This function enables dual signaling outcomes: suppression of the integrated stress response (ISR) and activation of...
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作者：Caballero, Madison; Koren, Amnon
作者单位：Roswell Park Comprehensive Cancer Center
摘要：Mutations are the source of evolutionary novelty but also the cause of genetic diseases and cancer. Mutation rates are known to be heterogeneous along the genome, however the extent to which local mutation rates vary among individuals in a population and are genetically determined is unknown. To test this, we analyzed the chromosomal distribution of somatic mutations in cell lines from 1,662 individuals, controlling for the confounding effects of DNA replication timing on local mutation rates ...
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作者：Grubmuller, Eric; Meier, Dimitri V.; Kreil, Melina; Schmit, Lynn; Scharl, Elena; Takata, Mamoru; Weig, Alfons; Steiger, Sandra
作者单位：University of Bayreuth; University of Bayreuth; Kyoto University; University of Bayreuth
摘要：Parents across diverse taxa modify the biotic or abiotic environments of their offspring. Such modifications may constitute ecological inheritance and are central to developmental niche construction, whereby organisms shape developmental conditions and selective pressures experienced by the next generation. Despite its theoretical importance, parental niche construction is often studied under simplified conditions or by focusing on single components of care, limiting our understanding of how m...
