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作者：Grunig, Marc; Rammer, Werner; Senf, Cornelius; Albrich, Katharina; Andre, Frederic; Augustynczik, Andrey L. D.; Baumann, Martin; Bohn, Friedrich J.; Bouwman, Meike; Bugmann, Harald; Collalti, Alessio; Cristal, Irina; Dalmonech, Daniela; De Coligny, Francois; Dobor, Laura; Dollinger, Christina; Espelta, Josep Maria; Forrester, David I.; Garcia-Gonzalo, Jordi; Gonzalez-Olabarria, Jose Ramon; Hiltner, Ulrike; Hlasny, Tomas; Honkaniemi, Juha; Huber, Nica; Jonard, Mathieu; Jonsson, Anna Maria; Kunstler, Georges; Lagergren, Fredrik; Lindner, Marcus; Mina, Marco; Moos, Christine; Morin, Xavier; Muys, Bart; Nabuurs, Gert-Jan; Nieberg, Mats; Patacca, Marco; Peltoniemi, Mikko; Reyer, Christopher P. O.; Schelhaas, Mart-Jan; Storms, Ilie; Thom, Dominik; Toigo, Maude; Seidl, Rupert
作者单位：Technical University of Munich; University of Basel; Swiss Tropical & Public Health Institute; University of Basel; Technical University of Munich; Natural Resources Institute Finland (Luke); University of Eastern Finland; International Institute for Applied Systems Analysis (IIASA); Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Wageningen University & Research; Swiss Federal Institutes of Technology Domain; ETH Zurich; Consiglio Nazionale delle Ricerche (CNR); Istituto per i Sistemi Agricoli e Forestali del Mediterraneo (ISAFoM-CNR); National Biodiversity Future Center; Universitat de Girona; Institut de Recherche pour le Developpement (IRD); INRAE; CIRAD; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Czech University of Life Sciences Prague; Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Commonwealth Scientific & Industrial Research Organisation (CSIRO); CSIRO Environment; Swiss Ornithological Institute; Lund University; INRAE; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); European Academy of Bozen-Bolzano; Institut de Recherche pour le Developpement (IRD); Universite PSL; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Ecole Pratique des Hautes Etudes (EPHE); KU Leuven; Wageningen University & Research; Potsdam Institut fur Klimafolgenforschung; University of Vermont; Universite de Bordeaux; INRAE
摘要：Wildfires, insect outbreaks, and storms cause large pulses of tree mortality. Climate change amplifies these forest disturbances, yet their future magnitude and extent remain uncertain. Here, we simulated future forest disturbance regimes at 100-meter resolution across Europe using a deep learning-based simulation framework. Our results show that forest disturbances will continue to increase throughout the 21st century, with disturbed areas more than doubling relative to the recent past under ...
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作者：Machado, Carlos Jose Saldanha; Vilani, Rodrigo Machado; Fearnside, Philip M.
作者单位：Fundacao Oswaldo Cruz; Universidade Federal do Estado do Rio de Janeiro; Institute Nacional de Pesquisas da Amazonia
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作者：Peng, Lizeng; Jin, Chuan
作者单位：Shandong Academy of Agricultural Sciences; Hainan University
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作者：Nisbet, Euan G.; Manning, Martin R.
作者单位：University of London; Victoria University Wellington
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作者：Kang, Jengmin; Benjamin, Daniel I.; Guo, Qiqi; Evangelista, Chauncey; Kim, Soochi; Arjona, Marina; Both, Pieter; Chung, Mingyu; Krishnan, Ananya K.; Dhaliwal, Gurkamal; Lam, Richard; Rando, Thomas A.
作者单位：Stanford University; Stanford Medicine; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Stanford University
摘要：Aging is characterized by a decline in the ability of tissue repair and regeneration after injury. In skeletal muscle, this decline is largely driven by impaired function of muscle stem cells (MuSCs) to efficiently contribute to muscle regeneration. We uncovered a cause of this aging-associated dysfunction: a cellular survivorship bias that prioritizes stem cell persistence at the expense of functionality. With age, MuSCs increased expression of a tumor suppressor, N-myc down-regulated gene 1 ...
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作者：Liu, Lei; Wang, Yushu; Dong, Ruikang; Fan, Dongxu; Meng, Si; Wu, Lang; Wu, Shengqiang; Xu, Wei; Feng, Mingwei; Zou, Ningmu; Yan, Qingyu; Hu, Zehua; Lu, Fei; Zhu, Shitong; Gao, Yuan; Ma, Liang; Shi, Yi; Li, Taotao; Wang, Jinlan; Wang, Xinran
作者单位：Suzhou Laboratory; Nanjing University; Nanjing University; Nanjing University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University; Southeast University - China
摘要：Kinetics determine the growth behavior of thin films, particularly for atomically thin transition-metal dichalcogenides. Metal-organic (MO) chemical vapor deposition (CVD) offers promise for scalable growth, but the reactions are kinetically limited, leading to nanometer-scale domain size and carbon contaminations. Here, we unveil the fundamental kinetic limitations and overcome them by introducing oxygen-assisted MOCVD (oxy-MOCVD) technology. By tuning reactions with oxygen, MO precursors are...
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作者：Travis, John
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作者：Kupferschmidt, Kai
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作者：Park, Jung Won; Kwak, Jiehoon; Kim, Keon-Woo; Jung, Saehoon; Nam, Chang Hyun; Kim, Hyun Jung; Lee, Sang Mee; Choi, Chanho; Ahn, Yongjin; Park, Ji-Hyung; Yoo, Jihwan; Shim, Jin-Kyoung; Cho, Hye Joung; Kim, Eui-Hyun; Kim, Chungyeul; Ahn, Sangjeong; Pusch, Stefan; von Deimling, Andreas; Chang, Jong Hee; Kim, Se Hoon; Kim, Hoon; Ju, Young Seok; Kang, Seok-Gu; Lee, Jeong Ho
作者单位：Korea Advanced Institute of Science & Technology (KAIST); Korea University; Korea University Medicine (KU Medicine); Yonsei University; Severance Hospital; Yonsei University Health System; Yonsei University; Severance Hospital; Yonsei University Health System; Yonsei University; Severance Hospital; Yonsei University Health System; Korea University; Korea University Medicine (KU Medicine); Korea University; Korea University Medicine (KU Medicine); Korea University; Korea University Medicine (KU Medicine); Korea University; Korea University Medicine (KU Medicine); Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System; Sungkyunkwan University (SKKU); Yonsei University; Yonsei University Health System
摘要：Identifying the cell of origin that harbors an initial driver mutation is key to understanding tumor evolution and for the development of new treatments. For isocitrate dehydrogenase (IDH)-mutant gliomas, the most common malignant primary brain tumor in young adults, the cell of origin is currently poorly understood. We conducted deep sequencing on 142 tissues from 70 individuals comprising tumors, peritumoral cortex or subventricular zones, and blood. Low-level IDH mutations were found in the...
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作者：Zhai, Di; Williams, Benedict A.; Pantaine, Loic R. E.; Chen, Yiding; Willis, Michael C.
作者单位：University of Oxford
摘要：Synthetic transformations that advance through excited states proceed by unconventional mechanistic pathways and deliver products not accessible using ground-state chemistry. The breadth of these synthetically valuable transformations is constrained by the range of molecules-and particularly the functional groups-that can deliver productive excited states, with most methods using the same functional groups that were defined more than 100 years ago. In this work, we show that N-silyl sulfinylam...
