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作者:Majdzadeh, Reza; Farzanegan, Mohammad Reza
作者单位:University of Essex; Philipps University Marburg
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作者:Ikegami, Shin; Mutterlose, Jorg; Sugiura, Kanta; Takeda, Yusuke; Derin, Mehmet Oguz; Kubota, Aya; Tainaka, Kazuki; Harada, Takahiro; Nishida, Harufumi; Iba, Yasuhiro
作者单位:Hokkaido University; Ruhr University Bochum; Japan Synchrotron Radiation Research Institute; Osaka Metropolitan University; Niigata University; Chuo University
摘要:Top predators drive changes in ecosystem structure. For the last similar to 370 million years, large-sized vertebrates have dominated the apex of the marine food chain, while invertebrates have served as smaller prey. Here we describe invertebrate top predators from this age of vertebrates, the earliest finned octopuses (Cirrata) from Late Cretaceous sediments (similar to 100 to 72 million years ago), as identified based on huge, exceptionally well-preserved fossil jaws and their wear. This ex...
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作者:Packin, Nizan Geslevich; Rabinovitz, Sharon
作者单位:City University of New York (CUNY) System; Baruch College (CUNY); University of Haifa; University of Haifa; University of Haifa; University of Haifa
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作者:Righi, Laurie; Stutzmann, Sandrine; Bader, Loriane; Lemopoulos, Alexandre; Blokesch, Melanie
作者单位:Swiss Federal Institutes of Technology Domain; Swiss School of Public Health (SSPH+); Ecole Polytechnique Federale de Lausanne
摘要:Bacteria often survive viral attack and environmental stress by sharing genes that enhance their defenses. The cholera pathogen Vibrio cholerae carries a sedentary chromosomal integron (SCI), a genetic element containing hundreds of mostly promoterless gene cassettes, about 10% of which encode antiviral systems. Cassettes are thought to reshuffle under stress to the favorable first array position, yet the SCI in pandemic V. cholerae has remained static for more than 60 years. In this study, we...
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作者:Cohen, Jon
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作者:Miranda, Marie Lynn
作者单位:University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
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作者:Sullivan-Allsop, Sam; Clark, Nick; Wang, Wendong; Cai, Rongsheng; Thornley, William; Hopkinson, David G.; Mchugh, James G.; Davies, Ben; Pattisson, Samuel; Dummer, Nicholas F.; Zhang, Rui; Lindley, Matthew; Tainton, Gareth; Harrison, Jack; De Latour, Hugo; Parker, Joseph; Swindell, Joshua; Castanon, Eli G.; Carl, Amy; Lewis, David J.; Martsinovich, Natalia; Allen, Christopher S.; Danaie, Mohsen; Logsdail, Andrew J.; Fal'ko, Vladimir; Hutchings, Graham J.; Summerfield, Alex; Gorbachev, Roman; Haigh, Sarah J.
作者单位:University of Manchester; University of Manchester; University of Manchester; Diamond Light Source; Cardiff University; Cardiff University; University of Sheffield; University of Oxford; University of Manchester
摘要:The structure and dynamics of adsorbed atoms (adatoms) at solid-liquid interfaces determine the performance of advanced catalysts, electrochemical devices, molecular separation technologies, and metal extraction from waste streams. However, in situ investigations of atomically dispersed metals in various chemical environments have been prevented by insufficient imaging resolution and solvent incompatibility. In this study, we combined a specimen design that provides atomic resolution in liquid...
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作者:van den Ameele, Jelle; Prudent, Julien
作者单位:University of Cambridge; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge
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作者:Goldman, Michael A.
作者单位:California State University System; San Francisco State University
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作者:Wang, Qin; Chen, Ziqi; Zhang, Guorong; Yang, Jiale; Hu, Runfan; Yao, Tongyue; Zeng, Cici; Zhang, Shugeng; Jiang, Wei; Zhu, Shu; Wang, Yucai
作者单位:Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要:In vivo delivery systems (IDSs) are designed to protect and transport therapeutics, but their clinical applications are hindered by low delivery efficiency. We identified gut microbiota as key regulators of efficacy of IDS-based therapies and that disrupting commensal-host interactions markedly improves drug and gene delivery. Intestinal epithelial cells sense microbial stimulation and remotely activate Kupffer cells through serotonin production, thereby driving hepatic IDS clearance. Transien...