Cellular survivorship bias as a mechanistic driver of muscle stem cell aging
成果类型：
Article
署名作者：
Kang, Jengmin; Benjamin, Daniel I.; Guo, Qiqi; Evangelista, Chauncey; Kim, Soochi; Arjona, Marina; Both, Pieter; Chung, Mingyu; Krishnan, Ananya K.; Dhaliwal, Gurkamal; Lam, Richard; Rando, Thomas A.
署名单位：
Stanford University; Stanford Medicine; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Stanford University
刊物名称：
SCIENCE
ISSN/ISSBN：
0036-8075; 1095-9203
DOI：
10.1126/science.ads9175
发表日期：
2026-01-29
页码：
517-521
关键词：
摘要：
Aging is characterized by a decline in the ability of tissue repair and regeneration after injury. In skeletal muscle, this decline is largely driven by impaired function of muscle stem cells (MuSCs) to efficiently contribute to muscle regeneration. We uncovered a cause of this aging-associated dysfunction: a cellular survivorship bias that prioritizes stem cell persistence at the expense of functionality. With age, MuSCs increased expression of a tumor suppressor, N-myc down-regulated gene 1 (NDRG1), which, by suppressing the mammalian target of rapamycin (mTOR) pathway, increased their long-term survival potential but at the cost of their ability to promptly activate and contribute to muscle regeneration. This delayed muscle regeneration with age may result from a trade-off that favors long-term stem cell survival over immediate regenerative capacity.
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