2026

最新文章

• DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality AI翻译
  作者：Tomaskovic, Ines; Prieto-Garcia, Cristian; Boskovic, Maria; Glumac, Mateo; Tsai, Tsung-Lin; Mosler, Thorsten; Kazi, Rubina; Rathore, Rajeshwari; Andrade, Jorge; Hoffmann, Marina; Giuliani, Giulio; Jacomin, Anne-Claire; Pereira, Raquel S.; Knop, Elias; Wachsmuth, Laurens; Beli, Petra; Husnjak, Koraljka; Pasparakis, Manolis; Ablasser, Andrea; Krause, Daniela S.; Potente, Michael; Papathanasiou, Stamatis; Terzic, Janos; Dikic, Ivan
  作者单位：Goethe University Frankfurt; Goethe University Frankfurt Hospital; University of Split; Institute of Molecular Biology (IMB); Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Goethe University Frankfurt; Goethe University Frankfurt; University of Cologne; University of Cologne; University of Cologne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ)
  摘要：DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease SPRTN in preventing DPC-driven immunity and its pathological consequences. Loss of SPRTN activity during replication and mitosis lead to unresolved DNA damage, chromosome segregation errors, micronuclei formation, and cytosolic DNA release that activates the cyclic GMP-AMP synthase (cGAS)-stimula...
• Robust perovskite nanocrystal emitters AI翻译
  作者：Wei, Keyu; Yuan, Mingjian
  作者单位：Nankai University
• A plea for public health support for war-torn El Obeid, Sudan AI翻译
  作者：Siddig, Emmanuel Edwar
  作者单位：University of Khartoum
• The lab that learns AI翻译
  作者：Abolhasani, Milad
  作者单位：North Carolina State University
• In Other Journals AI翻译
  作者：Nusinovich, Yevgeniya; Sirois, Cheri; Osorio, Joana; Vignieri, Sacha; Jin, Sumin; Yeston, Jake S.; Hessler, Angela
• The Rise and Fall of the Artificial State AI翻译
  作者：Veliz, Carissa
  作者单位：University of Oxford
• A CDK1 phospho-switch reprograms TRAIP to unload replisomes in mitosis AI翻译
  作者：Can, Geylani; Shyian, Maksym; Krishnamoorthy, Archana; Ahmed, Samreen; Lim, Yang; Wu, Alex; Pavani, Raphael; Zaher, Manal S.; Nussenzweig, Andre; Raschle, Markus; Wilson, Thomas E.; Glover, Thomas W.; Walter, Johannes C.; Pellman, David
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); RPTU University Kaiserslautern; Howard Hughes Medical Institute; Washington University (WUSTL)
  摘要：Cells entering mitosis with incompletely replicated DNA face catastrophic chromosome segregation failure. During interphase, the replisome-associated E3 ubiquitin ligase TRAIP ubiquitylates barriers in front of the fork to allow replisome progression. In mitosis, TRAIP is reprogrammed from a trans-acting to a cis-acting ligase that can ubiquitylate the replisome itself. This enables the processing of unreplicated DNA by promoting replisome disassembly, fork breakage, and joining of the broken ...
• Forest canopy decline under elevated CO2 during the Paleocene-Eocene Thermal Maximum AI翻译
  作者：Dunn, Regan E.; Dechesne, Marieke; Foreman, Brady Z.; Nace, Keifer; West, Jenna M.; Currano, Ellen D.
  作者单位：United States Department of the Interior; United States Geological Survey; Western Washington University; Whitman College; University of Wyoming
  摘要：Uncertainty remains regarding the impact of rapid anthropogenic warming on forest ecosystem structure, biodiversity, and function. As an analog, we reconstruct forest canopy density and compositional change in Wyoming, USA, through the Paleocene-Eocene Thermal Maximum (PETM), an interval of abrupt carbon increase and warming similar to 56 million years ago. We develop a proxy to quantify leaf area index and assess shifts in floral composition using palynomorphs. Forest canopies opened abruptly...
• Dengue vaccines need long-term surveillance AI翻译
  作者：Aguiar, Maira
  作者单位：Basque Center for Applied Mathematics (BCAM); Basque Foundation for Science
• The fungal pathogen Candida auris exposes chitin to trigger IFNγ and persist in hair follicles AI翻译
  作者：Merrill, Eric Dean; Prudent, Victoria; Basso, Pauline; Rapp, Emilie; Moghadam, Parna; Rodriguez, Abram; Hung, Ethan; Hurabielle, Charlotte; Cheng, Jeffrey; Cho, Raymond Jaihyun; Abegaze, Brook; Buck, Amanda; Pyper, Kennedi; Veinbachs, Alessandra; Wells, Elina K. C.; Scharschmidt, Tiffany C.; Rosenblum, Michael D.; Molofsky, Ari B.; Noble, Suzanne M.
  作者单位：University of California System; University of California San Francisco; US Department of Veterans Affairs; Veterans Health Administration (VHA); University of California System; University of California San Francisco; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Saint-Louis - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Candida auris is a multidrug-resistant fungus of major public health concern whose mechanisms for persistence on skin, a major risk factor for deadly outbreaks, remain unclear. In this study, we compared skin colonization by C. auris versus C. albicans to illuminate distinct fungal-immune interactions in mice. C. auris exhibited enhanced skin persistence, hair follicle tropism, and direct hair binding. Whereas C. albicans triggered a type 3/17-skewed sterilizing antifungal immune response, C. ...