-
作者：Tang, Yao; Zhang, Tianren; Yang, Dai-Bei; Schwartz, Jacob; Kloxin, Christopher J.; Saven, Jeffery G.; Pochan, Darrin J.
作者单位：University of Delaware; University of Pennsylvania; University of Delaware
摘要：Programmable control of protein or colloidal nanoparticle self-assembly into targeted nanostructures, while maintaining stability across extreme pH conditions, remains a major challenge. We designed coiled-coil bundlemer peptide nanoparticles that form ordered, hierarchical materials across an unusually broad pH range (1, 7, and 14) dependent on patchy surface charge display. Nematic liquid crystal formation was observed at low concentration (similar to 0.5 to 4 weight %) at pH 1 and pH 14, wh...
-
作者：Gao, Lei; Qiu, Xiang; Yang, Jun; Hu, Kangdelong; Li, Peilin; Li, Wei; Gao, Feng; Gallou, Fabrice; Kleinbeck, Florian; Lei, Xiaoguang
作者单位：Peking University; Wuhan University; Peking University; Novartis
摘要：Amide bond formation is widely used in pharmaceutical synthesis, typically involving stoichiometric coupling reagents to activate carboxylic acid substrates for a condensation reaction. As an alternative approach, we repurposed aldehyde dehydrogenases into oxidative amidases by creating a more hydrophobic and spacious catalytic pocket for amines to capture the thioester intermediate. This biocatalyst efficiently facilitates the formation of amide bonds between diverse aldehydes and amines. We ...
-
作者：Guo, Jason; Liang, Roger; Chung, Andrew; Li, Zhijie; Li, Boyuan; Chen, Eric; Li, Lin; Wang, Jingjing; Hsieh, Meng-Hsiung; Fang, Ivy Xiangyi; Kroger, Benjamin; Wang, Yunguan; Zhu, Min; Ren, Xiongzhao; Mannino, Greg; Jia, Yuemeng; Wei, Yonglong; Moore, Stephen; Siegwart, Daniel J.; Chung, Stephen S.; Wang, Zixi; Sharma, Tripti; Komjeti, Suman; Han, Yi; Gopal, Purva; Xiao, Guanghua; Wang, Tao; Zhu, Hao
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University System of Ohio; Cincinnati Children's Hospital Medical Center; University of Cincinnati; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
摘要：The origin of cancer is poorly understood because premalignant cells are rarely followed in their native environments. Although the spatial compartmentalization of metabolic functions is critical for proper liver function, it is unknown whether cancers arise from some zones but not others and whether there are metabolic determinants of cancer risk. Zone-specific, mosaic introduction of Ctnnb1 (catenin beta 1) and Arid2 (AT-rich interaction domain 2) mutations, commonly co-mutated genes in hepa...
-
作者：Berkowitz, Rachel
-
作者：Hashim, Bassim Mohammed; Yaseen, Zaher Mundher
作者单位：Scientific Research Commission; King Fahd University of Petroleum & Minerals
-
作者：Koenen, Mascha; Becher, Tobias; Pagano, Giulia; Del Gaudio, Ilaria; Barrero, Jorge A.; Montezano, Augusto C.; Ortiz, Jenelys Ruiz; Lin, Zeran; Gomez-Banoy, Nicolas; Amblard, Rose; Schriever, Daniel; Kars, Meltem E.; Rubinelli, Luisa; Halix, Sarah J.; Cao, Zhen Fang Huang; Zeng, Xing; Butler, Scott D.; Itan, Yuval; Touyz, Rhian M.; Di Lorenzo, Annarita; Cohen, Paul
作者单位：Rockefeller University; Ruprecht Karls University Heidelberg; Cornell University; Weill Cornell Medicine; Universidad Nacional de Colombia; McGill University; Rockefeller University; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; Heinrich Heine University Dusseldorf; Icahn School of Medicine at Mount Sinai; University of Texas System; University of Texas Southwestern Medical Center; Cornell University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
摘要：Excess adiposity is a major risk factor for hypertension and heart disease. Brown fat is associated with protection from cardiovascular pathology, but whether this relationship is causal remains unknown. In this work, we investigate the role of mouse beige fat, as a model of human inducible brown fat, in adipocyte-vascular cross-talk. Using adipocyte-specific Prdm16 knockout mice with a loss of beige adipocyte identity, we discovered marked remodeling of perivascular adipose tissue, increased ...
-
作者：Mousazadehgavan, Milad; Madani, Kaveh
作者单位：Liverpool John Moores University
-
作者：Shin, June-Chul; Kim, Jeehwan
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
-
作者：Wang, Belinda; Vartak, Rasika; Hennick, Kelsey M.; Zaltsman, Yefim; Naing, Zun Zar Chi; Polacco, Benjamin J.; Bashir, Ali; Eckhardt, Manon; Bouhaddou, Mehdi; Xu, Jiewei; Sun, Nawei; Lasser, Micaela C.; Zhou, Yuan; McKetney, Justin; Guiley, Keelan Z.; Gniewek, Pawel; Chan, Una; Amirani, Naufa; Griffiths, Owen; Chadha, Nishant; Tognatta, Reshmi; Cakir, Merve; Gordon, Martin; Khare, Prachi; Drake, Sam; Drury, Vanessa; Burke, David F.; Gonzalez, Silvano; Alkhairy, Sahar; Thomas, Reuben; Lam, Stephanie; Morris, Montana; Bader, Ethel; Dos Santos, Melanie; Komarova, Anastassia V.; Bennett, Maxwell; Ennis, Craig; Castillo, Octavio; Lim, Yvonne; Martin, Robert; Seyler, Meghan; Baum, Tierney; Krasnoff, Rebecca; Wang, George; Middya, Sagnik; Wang, Sheng; Pham, Presley; Arbelaez, Juan; Pratt, Dexter; Bali, Sofia; Chag, Shivali; Kaye, Julia A.; Mahmood, Nadir; Spraggon, Lee; Rolland, Thomas; Hervey-Jumper, Shawn; Fraser, James S.; Bourgeron, Thomas; Finkbeiner, Steven; Demeret, Caroline; Swaney, Danielle L.; Bandyopadhyay, Sourav; Ideker, Trey; Beltrao, Pedro; Willsey, Helen Rankin; Huttenhain, Ruth; Obernier, Kirsten; Nowakowski, Tomasz J.; State, Matthew W.; Willsey, A. Jeremy; Krogan, Nevan J.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; University of California System; University of California San Diego; Universite Paris Cite; Pasteur Network; Institut Pasteur Paris; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; Universite Paris Cite; Pasteur Network; Institut Pasteur Paris; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of California System; University of California San Francisco; University of California System; University of California San Francisco; AstraZeneca; University of California System; University of California Los Angeles; Columbia University; New York University; Vanderbilt University; New York University; Stanford University
摘要：Systematic mapping of protein-protein interaction (PPI) networks and determining how causal mutations rewire them in autism spectrum disorder (ASD) provide a powerful framework for uncovering disease mechanisms and therapeutic opportunities. Using affinity purification-mass spectrometry, we systematically mapped PPIs for 100 high-confidence ASD genes, uncovering more than 1800 interactions. By assessing the impact of pathogenic missense mutations, leveraging AlphaFold, and validating key findi...
-
作者：Cozzolino, Alessio
