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作者：Oxley, Adam; Ye, Chunchun; Han, Seok Ju; Zhao, Guoke; Guo, Yihao; Shi, Xin; Liu, Jie; Smith, Keenan; Sarter, Mona; Upadhyaya, Lakshmeesha; Hong, Shanshan; Samaras, Vasilios G.; Qian, Qin; Liu, Yanan; Nichol, Gary S.; Liu, Yiqun; Nunes, Suzana P.; Foglia, Fabrizia; Jiang, Jianwen; Wang, Anqi; McKeown, Neil B.; Livingston, Andrew G.; Jiang, Zhiwei
作者单位：University of London; Queen Mary University London; University of Edinburgh; Sinopec; King Abdullah University of Science & Technology; Wuhan Institute of Technology; University of London; University College London; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; King Abdullah University of Science & Technology; King Abdullah University of Science & Technology; Hainan University; King Abdullah University of Science & Technology; National University of Singapore; Nanyang Technological University; Nanyang Technological University
摘要：Membrane technologies offer an energy-efficient alternative to conventional distillation for hydrocarbon fractionation, but they suffer from a trade-off between fast liquid transport and high molecular selectivity. We report a scalable approach to fabricate polymer membranes with stable interconnected pathways by locking in their intrinsic microporosity. This locking strategy reduces polymer swelling and preserves the subnanometer pore structure in hydrocarbon liquids, resulting in 10-fold hig...
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作者：Ryu, Jeongeun; Colombani, Mathieu; Mollier, Corentin; Marthelot, Joel; Forterre, Yoel
作者单位：Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; CNRS - Institute for Engineering & Systems Sciences (INSIS); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); UNICANCER; Universite PSL; CNRS - National Institute for Biology (INSB); Institut Curie
摘要：Plants can move rapidly without muscles, as seen in the Venus flytrap's snapping lobes-a long-standing puzzle in plant biomechanics. Trap closure involves an elastic instability, but the active mechanical driver has remained elusive. Using in situ hydraulic and mechanical measurements, we identified the motor driving this transition. Closure occurs too quickly to be explained by water transport, revealing a distinct, nonhydraulic mechanism: a rapid (about one second) softening of the epidermal...
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作者：Kuang, Yuyan; Xia, Ziqian
作者单位：University of California System; University of California Davis; Stanford University
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作者：Conde, Joao
作者单位：Universidade Nova de Lisboa
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作者：Rodriguez, Grayson E.; Zhao, Yang; Nishiga, Yoko; Peprah, Frank; Shen, Jiao; Abhiraman, Gita C.; Ogishi, Masato; Zhang, Chenyu; Saco, Justin; Waghray, Deepa; Serasanambati, Mamatha; Torres, Leonel; Simone, Brandon W.; Su, Leon; Wilson, Steven C.; Yang, Aerin; Sun, Qinli; Picton, Lora; Saxton, Robert A.; Bhandarkar, Vidit; Lee, Madeline J.; Andrews, Elizabeth; Jiang, Hua; Obenaus, Matthias; Yen, Michelle; Atajanova, Tavus; Blish, Catherine A.; Spranger, Stefani; Wherry, E. John; Kirane, Amanda; Ribas, Antoni; Raulet, David H.; Kalbasi, Anusha; Dougan, Stephanie K.; Dougan, Michael; Sage, Julien; Garcia, K. Christopher
作者单位：Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford Medicine; Stanford University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; University of California System; University of California Berkeley; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Stanford Medicine; Stanford University; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; Massachusetts Institute of Technology (MIT); Stanford Medicine; Stanford University; Chan Zuckerberg Initiative (CZI); University of Pennsylvania; Pennsylvania Medicine; University of California System; UCLA Jonsson Comprehensive Cancer Center; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford Cancer Institute; Harvard University; Harvard Medical School; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Howard Hughes Medical Institute
摘要：Cytokines dimerize two receptor chains to activate Janus kinases and signal transducer and activator of transcription (STAT) transcription factors that regulate immune cells, but they have therapeutic liabilities. We engineered Trikines to compel cis formation of three-chain cytokine receptor complexes at the cell surface that induce bespoke STAT transcriptional signaling programs. Trikines coactivated phosphorylation of STAT5 (pSTAT5) and pSTAT3 signatures distinct from natural cytokines by a...
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作者：Cohen, Jon
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作者：Trethewey, Laura
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作者：Hirano, Hisato; Tsuji, Naoko; Chiba, Shinobu; Nureki, Osamu
作者单位：University of Tokyo; Kyoto Sangyo University
摘要：Natural transformation is one of the major pathways of horizontal gene transfer in bacteria, enabling the acquisition of extracellular DNA and its integration into the host genome. ComEC is a membrane protein responsible for DNA translocation in this process, yet its precise function and structure have remained elusive. Here, we report cryo-electron microscopy structures of ComEC in DNA-free, single-stranded DNA (ssDNA)-bound, and double-stranded DNA (dsDNA)-bound forms, together with biochemi...
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作者：Zhang, Yue; Ouadah, Youcef; Liu, Yin; Kumar, Maya E.; Morck, Makenna M.; Krasnow, Mark A.
作者单位：Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Howard Hughes Medical Institute; Stanford University; Stanford University; Stanford Medicine; Stanford Medicine; Stanford University; California Institute of Technology; Howard Hughes Medical Institute
摘要：Stem cells proliferate after injury to repair damaged tissue, and chronic injury can promote cancer. However, the injury-activated signals and regulatory mechanisms, and their relationship to cancer, are poorly understood. Here, we identified insulin-like growth factor 2 (Igf2) as an injury-activated mitogen for lung neuroendocrine stem cells, which are facultative airway progenitors and a cell of origin of small-cell lung cancer in mice. Igf2 was constitutively produced by the stem cells but ...
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作者：Cao, Zebin; Liu, Lijun; Wan, Bo; Chen, Ling; Lundstrom, Craig
作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Geology & Geophysics, CAS; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Yellowstone is widely recognized for its crustal magma reservoirs replenished by asthenospheric melts. However, how primary melts traverse the rigid lithosphere and evolve into bimodal volcanism remains unclear. By leveraging multidisciplinary observations and a data-oriented geodynamic modeling approach, we demonstrate that magma generation and migration in the Yellowstone region are primarily governed by lithospheric tectonics, with negligible contribution from the mantle plume. Below Yellow...
