3期

最新文章

• Platform-independent estimation of human physiological time from single blood samples AI翻译
  作者：Huang, Yitong; Braun, Rosemary
  作者单位：Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; The Santa Fe Institute
  摘要：Abundant epidemiological evidence links circadian rhythms to human health, from heart disease to neurodegeneration. Accurate determination of an individual's circadian phase is critical for precision diagnostics and personalized timing of therapeutic interventions. To date, however, we still lack an assay for physiological time that is accurate, minimally burdensome to the patient, and readily generalizable to new data. Here, we present Time Machine, an algorithm to predict the human circadian...
• Spartin-mediated lipid transfer facilitates lipid droplet turnover AI翻译
  作者：Wan, Neng; Hong, Zhouping; Parson, Matthew A. H.; Korfhage, Justin L.; Burke, John E.; Melia, Thomas J.; Reinisch, Karin M.
  作者单位：Yale University; University of Victoria; University of British Columbia
  摘要：Lipid droplets (LDs) are organelles critical for energy storage and membrane lipid homeostasis, whose number and size are carefully regulated in response to cellular conditions. The molecular mechanisms underlying lipid droplet biogenesis and degradation, however, are not well understood. The Troyer syndrome protein spartin (SPG20) supports LD delivery to autophagosomes for turnover via lipophagy. Here, we characterize spartin as a lipid transfer protein whose transfer ability is required for ...
• Rapid single- particle chemical imaging of nanoplastics by SRS microscopy AI翻译
  作者：Qiana, Naixin; Gaoa, Xin; Lang, Xiaoqi; Deng, Huiping; Bratu, Teodora Maria; Chen, Qixuan; Stapleton, Phoebe; Yan, Beizhan; Min, Wei
  作者单位：Columbia University; Columbia University; Columbia University; Rutgers University System; Rutgers University New Brunswick; Columbia University
  摘要：Plastics are now omnipresent in our daily lives. The existence of microplastics (1 mu m to 5 mm in length) and possibly even nanoplastics (<1 mu m) has recently raised health concerns. In particular, nanoplastics are believed to be more toxic since their smaller size renders them much more amenable, compared to microplastics, to enter the human body. However, detecting nanoplastics imposes tremendous analytical challenges on both the nano- level sensitivity and the plastic- identifying specifi...
• Fenton-like activity and pathway modulation via single-atom sites and pollutants comediates the electron transfer process AI翻译
  作者：Guo, Jirui; Wang, Yujie; Shang, Yanan; Yin, Kexin; Li, Qian; Gao, Baoyu; Li, Yanwei; Duan, Xiaoguang; Xu, Xing
  作者单位：Shandong University; Shandong University of Science & Technology; Shandong University; University of Adelaide
  摘要：The studies on the origin of versatile oxidation pathways toward targeted pollutants in the single-atom catalysts (SACs)/peroxymonosulfate (PMS) systems were always associated with the coordination structures rather than the perspective of pollutant characteristics, and the analysis of mechanism commonality is lacking. In this work, a variety of single-atom catalysts (M-SACs, M: Fe, Co, and Cu) were fabricated via a pyrolysis process using lignin as the complexation agent and substrate precurs...
• The immunoglobulin J chain is an evolutionarily co-opted chemokine AI翻译
  作者：Kawasakia, Kazuhiko; Ohtab, Yuko; Castroc, Caitlin D.; Flajnikb, Martin F.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University System of Maryland; University of Maryland Baltimore; University of Chicago
  摘要：The joining (J) chain regulates polymerization of multimeric Immunoglobulin(Ig)M and IgA, forming a disulfide bond to the C termini of their Ig heavy chains, and it controls IgM/IgA transport across mucosal epithelia. Like Ig itself and human-like adaptive immunity, J chain emerged in jawed vertebrates (gnathostomes), but its origin has remained mysterious since its discovery over 50 y ago. Here, we show unexpectedly that J chain is a member of the CXCL chemokine family. The J chain gene (JCHA...
• High-resolution map of the Fc functions mediated by COVID-19-neutralizing antibodies AI翻译
  作者：Paciello, Ida; Maccari, Giuseppe; Pantano, Elisa; Andreano, Emanuele; Rappuoli, Rino
  作者单位：University of Siena
  摘要：A growing body of evidence shows that fragment crystallizable (Fc)-dependent antibody effector functions play an important role in protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To unravel the mechanisms that drive these responses, we analyzed the phagocytosis and complement deposition mediated by a panel of 482 human monoclonal antibodies (nAbs) neutralizing the original Wuhan virus, expressed as recombinant IgG1. Our study confirmed that nAbs no longe...
• Sm complex assembly and 5′ cap trimethylation promote selective processing of snRNAs by the 3′ exonuclease TOE1 AI翻译
  作者：Ma, Tiantai; Xiong, Erica S.; Lardelli, Rea M.; Lykke- Andersen, Jens
  作者单位：University of California System; University of California San Diego
  摘要：Competing exonucleases that promote 3 ' end maturation or degradation direct quality control of small non- coding RNAs, but how these enzymes distinguish normal from aberrant RNAs is poorly understood. The Pontocerebellar Hypoplasia 7 (PCH7)-associated 3 ' exonuclease TOE1 promotes maturation of canonical small nuclear RNAs (snRNAs). Here, we demonstrate that TOE1 achieves specificity toward canonical snRNAs through their Sm complex assembly and cap trimethylation, two features that distinguis...
• LHFPL5 is a key element in force transmission from the tip link to the hair cell mechanotransducer channel AI翻译
  作者：Beurga, Maryline; Schwalbacha, Evan Travis; Fettiplace, Robert
  作者单位：University of Wisconsin System; University of Wisconsin Madison
  摘要：During auditory transduction, sound- evoked vibrations of the hair cell stereociliary bundles open mechanotransducer (MET) ion channels via tip links extending from one stereocilium to its neighbor. How tension in the tip link is delivered to the channel is not fully understood. The MET channel comprises a pore- forming subunit, transmembrane channel- like protein (TMC1 or TMC2), aided by several accessory proteins, including LHFPL5 (lipoma HMGIC fusion partner- like 5). We investigated the ro...
• Climate migration amplifies demographic change and population aging AI翻译
  作者：Hauer, Mathew E.; Jacobs, Sunshine A.; Kulp, Scott A.
  作者单位：State University System of Florida; Florida State University; State University System of Florida; Florida State University
  摘要：The warnings of potential climate migration first appeared in the scientific literature in the late 1970s when increased recognition that disintegrating ice sheets could drive people to migrate from coastal cities. Since that time, scientists have modeled potential climate migration without integrating other population processes, potentially obscuring the demographic amplification of this migration. Climate migration could amplify demographic change-enhancing migration to destinations and supp...
• The ergodicity question when imaging DNA conformation using liquid cell electron microscopy AI翻译
  作者：Li, Jia- Ye; Liu, Fan; Xu, Jing; Kim, Ye-Jin; Kwon, Oh-Hoon; Xia, Bin; Wang, Huan; Granick, Steve
  作者单位：Peking University; Peking University; Ulsan National Institute of Science & Technology (UNIST); Institute for Basic Science - Korea (IBS); University of Massachusetts System; University of Massachusetts Amherst
  摘要：Assessing the ergodicity of graphene liquid cell electron microscope measurements, we report that loop states of circular DNA interconvert reversibly and that loop numbers fol-low the Boltzmann distribution expected for this molecule in bulk solution, provided that the electron dose is low (80- keV electron energy and electron dose rate 1-20 e(-) angstrom(-2) s(-1)). This imaging technique appears to act as a slow motion camera that reveals equilibrated distributions by imaging the time averag...