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作者：Radulovic, Maja; Stenmark, Harald
作者单位：University of Oslo
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作者：Tazai, Rina; Yamakawa, Youichi; Kontani, Hiroshi
作者单位：Kyoto University; Nagoya University
摘要：In kagome metals, the chiral current order parameter eta with time-reversal-symmetry-breaking is the source of various exotic electronic states, while the method of controlling the current order and its interplay with the star-of-David bond order phi are still unsolved. Here, we reveal that tiny uniform orbital magnetization M-orb[eta, phi] is induced by the chiral current order, and its magnitude is prominently enlarged under the presence of the bond order. Importantly, we derive the magnetic...
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作者：Ulschmid, Caden M.; Sun, Miranda R.; Jabbarpour, Christopher R.; Steward, Austin C.; Rivera-Gonzalez, Kenneth S.; Cao, Jocelyn; Martin, Alexander A.; Barnes, Macy; Wicklund, Lorena; Madrid, Andy; Papale, Ligia A.; Joseph, Diya B.; Vezina, Chad M.; Alisch, Reid S.; Lipinski, Robert J.
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：Orofacial clefts of the lip and palate are widely recognized to result from complex gene-environment interactions, but inadequate understanding of environmental risk factors has stymied development of prevention strategies. We interrogated the role of DNA methylation, an environmentally malleable epigenetic mechanism, in orofacial devel-opment. Expression of the key DNA methyltransferase enzyme DNMT1 was detected throughout palate morphogenesis in the epithelium and underlying cranial neural c...
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作者：Zhou, Chuan-Miao; Li, Jian-Xu; Zhang, Tian-Qi; Xu, Zhou-Geng; Ma, Miao-Lian; Zhang, Peng; Wang, Jia-Wei
作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; Shanghai Chenshan Botanical Garden; Chinese Academy of Sciences; ShanghaiTech University
摘要：The phytohormone cytokinin has various roles in plant development, including meristem maintenance, vascular differentiation, leaf senescence, and regeneration. Prior investiga- tions have revealed that cytokinin acts via a phosphorelay similar to the two-component system by which bacteria sense and respond to external stimuli. The eventual tar- gets of this phosphorelay are type-B ARABIDOPSIS RESPONSE REGULATORS (B-ARRs), containing the conserved N-terminal receiver domain (RD), middle DNA bin...
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作者：Bennett, Neal K.; Lee, Megan; Orr, Adam L.; Nakamura, Ken
作者单位：University of California System; University of California San Francisco; The J David Gladstone Institutes; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：Respiratory chain dysfunction can decrease ATP and increase reactive oxygen species (ROS) levels. Despite the importance of these metabolic parameters to a wide range of cellular functions and disease, we lack an integrated understanding of how they are differentially regulated. To address this question, we adapted a CRISPRi- and FACS-based platform to compare the effects of respiratory gene knockdown on ROS to their effects on ATP. Focusing on genes whose knockdown is known to decrease mitoch...
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作者：Graham, Kristin; Chandrasekaran, Aravind; Wang, Liping; Yang, Noel; Lafer, Eileen M.; Rangamani, Padmini; Stachowiak, Jeanne C.
作者单位：University of Texas System; University of Texas Austin; University of California System; University of California San Diego; University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas Austin
摘要：Cellular remodeling of actin networks underlies cell motility during key morphological events, from embryogenesis to metastasis. In these transformations, there is an inherent competition between actin branching and bundling, because steric clashes among branches create a mechanical barrier to bundling. Recently, liquid-like condensates consisting purely of proteins involved in either branching or bundling of the cytoskeleton have been found to catalyze their respective functions. Yet in the c...
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作者：Hueer, Janina; Saxena, Pankhuri; Treue, Stefan
作者单位：Leibniz Association; Deutsches Primatenzentrum (DPZ); Max Planck Society
摘要：Spatial attention represents a powerful top-down influence on sensory responses in primate visual cortical areas. The frontal eye field (FEF) has emerged as a key candidate area for the source of this modulation. However, it is unclear whether the FEF exerts its effects via its direct axonal projections to visual areas or indirectly through other brain areas and whether the FEF affects both the enhancement of attended and the suppression of unattended sensory responses. We used pathway-selecti...
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作者：Puthusseryppady, Vaisakh; Cossio, Daniela; Chrastil, Elizabeth R.
作者单位：University of California System; University of California Irvine
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作者：Ao, Hong; Ruan, Jiaoyang; Martinon-Torres, Maria; Krapp, Mario; Liebrand, Diederik; Dekkers, Mark J.; Caley, Thibaut; Jonell, Tara N.; Zhu, Zongmin; Huang, Chunju; Li, Xinxia; Zhang, Ziyun; Sun, Qiang; Yang, Pingguo; Jiang, Jiali; Li, Xinzhou; Xie, Xiaoxun; Song, Yougui; Qiang, Xiaoke; Zhang, Peng; An, Zhisheng
作者单位：Chinese Academy of Sciences; Institute of Earth Environment, CAS; Laoshan Laboratory; Institute for Basic Science - Korea (IBS); Pusan National University; Centro Nacional de Investigacion de La Evolucion Humana (CENIEH); University of London; University College London; University of Cambridge; University of Manchester; Utrecht University; Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); University of Glasgow; China University of Geosciences; Xi'an University of Science & Technology; Shanxi Normal University; Xi'an Jiaotong University; Beijing Normal University
摘要：The relationship between initial Homo sapiens dispersal from Africa to East Asia and the orbitally paced evolution of the Asian summer monsoon (ASM)-currently the largest monsoon system-remains underexplored due to lack of coordinated synthesis of both Asian paleoanthropological and paleoclimatic data. Here, we investigate orbital-scale ASM dynamics during the last 280 thousand years (kyr) and their likely influences on early H. sapiens dispersal to East Asia, through a unique integration of i...
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作者：Dee, Thomas S.
作者单位：Stanford University
摘要：The broad and substantial educational harm caused by the COVID-19 pandemic has motivated large federal, state, and local investments in academic recovery. However, the success of these efforts depends in part on students' regular school attendance. Using state-level data, I show that the rate of chronic absenteeism among US public-school students grew substantially as students returned to in-person instruction. Specifically, between the 2018-2019 and 2021-2022 school years, the share of studen...
