3期

最新文章

• Network physics of attractive colloidal gels: Resilience, rigidity, and phase diagram AI翻译
  作者：Nabizadeh, Mohammad; Nasirian, Farzaneh; Li, Xinzhi; Saraswat, Yug; Waheibid, Rony; Hsiao, Lilian C.; Bi, Dapeng; Ravandi, Babak; Jamali, Safa
  作者单位：Northeastern University; Northeastern University; Northeastern University; Carnegie Mellon University
  摘要：Colloidal gals exhibit solid-like behavior at vanishingly small fractions of solids, owing to ramified space-spanning networks that form due to particle-particle interactions. These networks give the gel its rigidity, and with stronger attractions the elasticity grows as well. The emergence of rigidity can be described through a mean field approach; nonetheless fundamental understanding of how rigidity varies in gels of different attractions is lacking. Moreover, recovering an accurate gelatio...
• Defected twisted ring topology for autonomous periodic flip-spin-orbit soft robot AI翻译
  作者：Qi, Fangjie; Li, Yanbin; Hong, Yaoye; Zhao, Yao; Qing, Haitao; Yin, Jie
  作者单位：North Carolina State University
  摘要：Periodic spin-orbit motion is ubiquitous in nature, observed from electrons orbiting nuclei to spinning planets orbiting the Sun. Achieving autonomous periodic orbiting motions, along circular and noncircular paths, in soft mobile robotics is crucial for adaptive and intelligent exploration of unknown environments-a grand challenge yet to be accomplished. Here, we report leveraging a closed-loop twisted ring topology with a defect for an autonomous soft robot capable of achieving periodic spin...
• Bridging and breaking silos: Transformational governance of the migration-sustainability nexus AI翻译
  作者：Zickgraf, Caroline; Jolivet, Dominique; Fry, Claudia; Boyd, Emily; Fabos, Anita
  作者单位：University of Liege; University of Amsterdam; Lund University; Clark University
  摘要：Sustainability and migration are typically treated as discrete policy spheres in inter-national, national, and local fora, separated in governance structures and institutions. This results in policy incoherence that hinders just transitions toward more sustainable societies cognizant of mobile realities. This explorative effort identifies the (dis)connec-tions between policy domains using data collected on how the sustainability-migration nexus is governed in four countries with a special emph...
• Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents Infection of Omicron lineages AI翻译
  作者：Marcotte, Harold; Cao, Yunlong; Zuo, Fanglei; Simonelli, Luca; Sammartino, Jose Camilla; Pedotti, Mattia; Sun, Rui; Cassaniti, Irene; Hagbom, Marie; Piralla, Antonio; Yang, Jinxuan; Du, Likun; Percivalle, Elena; Bertoglio, Federico; Schubert, Maren; Abolhassani, Hassan; Sherina, Natalia; Guerra, Concetta; Borte, Stephan; Rezaei, Nima; Kumagai-Braesch, Makiko; Xue, Yintong; Su, Chen; Yan, Qihong; He, Ping; Groenwall, Caroline; Klareskog, Lars; Calzolai, Luigi; Cavalli, Andrea; Wang, Qiao; Robbiani, Davide F.; Hust, Michael; Shi, Zhengli; Feng, Liqiang; Svensson, Lennart; Chen, Ling; Bao, Linlin; Baldanti, Fausto; Xiao, Junyu; Qin, Chuan; Hammarstrom, Lennart; Yang, Xinglou; Varani, Luca; Xie, Xiaoliang Sunney; Pan-Hammarstrom, Qiang
  作者单位：Karolinska Institutet; Changping Laboratory; Peking University; Universita della Svizzera Italiana; IRCCS Fondazione San Matteo; Linkoping University; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Braunschweig University of Technology; Tehran University of Medical Sciences; Karolinska Institutet; Peking University; Peking University; Chinese Academy of Sciences; Guangzhou Institute of Biomedicine & Health, CAS; State Key Laboratory of Respiratory Disease; Karolinska Institutet; Karolinska University Hospital; Karolinska Institutet; Karolinska University Hospital; European Commission Joint Research Centre; EC JRC ISPRA Site; Fudan University; Chinese Academy of Sciences; Wuhan Institute of Virology, CAS; Karolinska Institutet; Guangzhou Laboratory; Chinese Academy of Medical Sciences - Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; University of Pavia
  摘要：The emergence of Omicron lineages and descendent subvariants continues to present a severe threat to the effectiveness of vaccines and therapeutic antibodies. We have previ- ously suggested that an insufficient mucosal immunoglobulin A (IgA) response induced by the mRNA vaccines is associated with a surge in breakthrough infections. Here, we further show that the intramuscular mRNA and/or inactivated vaccines cannot suffi- ciently boost the mucosal secretory IgA response in uninfected individu...
• In-patient evolution of a high-persister Escherichia coli strain with reduced in vivo antibiotic susceptibility AI翻译
  作者：Parsons, Joshua B.; Sidders, Ashelyn E.; Velez, Amanda Z.; Hanson, Blake M.; Angeles-Solano, Michelle; Ruffin, Felicia; Rowe, Sarah E.; Arias, Cesar A.; Fowler, Vance G., Jr.; Thaden, Joshua T.; Conlon, Brian P.
  作者单位：Duke University; University of North Carolina; University of North Carolina Chapel Hill; University of Texas System; University of Texas Health Science Center Houston; Houston Methodist; Houston Methodist; Cornell University; Weill Cornell Medicine
  摘要：Gram-negative bacterial bloodstream infections (GNB-BSI) are common and frequently lethal. Despite appropriate antibiotic treatment, relapse of GNB-BSI with the same bacterial strain is common and associated with poor clinical outcomes and high healthcare costs. The role of persister cells, which are sub-populations of bacteria that survive for prolonged periods in the presence of bactericidal antibiotics, in relapse of GNB-BSI is unclear. Using a cohort of patients with relapsed GNB-BSI, we a...
• Minimal requirements for the epigenetic inheritance of engineered silent chromatin domains AI翻译
  作者：Yuan, Andy H.; Moazed, Danesh
  作者单位：Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Harvard Medical School
  摘要：Mechanisms enabling genetically identical cells to differentially regulate gene expression are complex and central to organismal development and evolution. While gene silencing pathways involving DNA sequence-specific recruitment of histone- modifying enzymes are prevalent in nature, examples of sequence-independent heritable gene silencing are scarce. Studies of the fission yeast Schizosaccharomyces pombe indicate that sequence- independent propagation of heterochromatin can occur but require...
• Conformity to continuous and discrete ordered traits AI翻译
  作者：Mora, Elisa Heinrich; Denton, Kaleda K.; Palmer, Michael E.; Feldman, Marcus W.
  作者单位：Stanford University; The Santa Fe Institute
  摘要：Models of conformity and anticonformity have typically focused on cultural traits with unordered variants, such as baby names, strategies (cooperate/defect), or the presence/absence of an innovation. There have been fewer studies of conformity to cultural traits with ordered variants, such as level of cooperation (low, medium, high) or proportion of time spent on a task (0% to 100%). In these studies of ordered cultural traits, conformity is defined as a preference for the mean trait value in ...
• Toward the quantification of α-synuclein aggregates with digital seed amplification assays AI翻译
  作者：Gilboa, Tal; Swank, Zoe; Thakur, Rohan; Gould, Russell A.; Ooi, Kean Hean; Norman, Maia; Flynn, Elizabeth A.; Deveney, Brendan T.; Chen, Anqi; Borberg, Ella; Kuzkina, Anastasia; Ndayisaba, Alain; Khurana, Vikram; Weitz, David A.; Walt, David R.
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University; Harvard Medical School; Harvard University; Harvard University; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University
  摘要：The quantification and characterization of aggregated alpha-synuclein in clinical samples offer immense potential toward diagnosing, treating, and better understanding neuro-degenerative synucleinopathies. Here, we developed digital seed amplification assays to detect single alpha-synuclein aggregates by partitioning the reaction into microcompartments. Using pre-formed alpha-synuclein fibrils as reaction seeds, we measured aggregate concentrations as low as 4 pg/mL. To improve our sensitivity...
• Sexual selection and the evolution of dinosaur flight AI翻译
  作者：Brusatte, Stephen L.
  作者单位：University of Edinburgh
• Fault roughness controls injection-induced seismicity AI翻译
  作者：Wang, Lei; Kwiatek, Grzegorz; Renard, Francois; Guerin-Marthe, Simon; Rybacki, Erik; Bohnhoff, Marco; Naumann, Michael; Dresen, Georg
  作者单位：Helmholtz Association; Helmholtz-Center Potsdam GFZ German Research Center for Geosciences; University of Oslo; University of Oslo; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Gustave-Eiffel; Universite Savoie Mont Blanc; Institut National Polytechnique de Grenoble; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Free University of Berlin; University of Potsdam
  摘要：Surface roughness ubiquitously prevails in natural faults across various length scales. Despite extensive studies highlighting the important role of fault geometry in the dynamics of tectonic earthquakes, whether and how fault roughness affects fluid-induced seismicity remains elusive. Here, we investigate the effects of fault geometry and stress heterogeneity on fluid-induced fault slip and associated seismicity characteristics using laboratory experiments and numerical modeling. We perform f...