5期

最新文章

• Single- particle imaging of nanomedicine entering the brain AI翻译
  作者：Wei, Mian; Qian, Naixin; Gao, Xin; Lang, Xiaoqi; Song, Donghui; Min, Wei
  作者单位：Columbia University; Columbia University; Columbia University
  摘要：Nanomedicine has emerged as a revolutionary strategy of drug delivery. However, fundamentals of the nano-neuro interaction are elusive. In particular, whether nanocarriers can cross the blood-brain barrier (BBB) and release the drug cargo inside the brain, a basic process depicted in numerous books and reviews, remains controversial. Here, we develop an optical method, based on stimulated Raman scattering, for imaging nanocarriers in tissues. Our method achieves a suite of capabilities-single-...
• How to recycle an EV battery AI翻译
  作者：Ornes, Stephen
• The probability of epidemic burnout in the stochastic SIR model with vital dynamics AI翻译
  作者：Parsons, Todd L.; Bolker, Benjamin M.; Dushoff, Jonathan; Earn, David J. D.
  作者单位：Universite Paris Cite; Sorbonne Universite; McMaster University; McMaster University; McMaster University
  摘要：We present an approach to computing the probability of epidemic burnout, i.e., the probability that a newly emergent pathogen will go extinct after a major epidemic. Our analysis is based on the standard stochastic formulation of the Susceptible -InfectiousRemoved (SIR) epidemic model including host demography (births and deaths) and corresponds to the standard SIR ordinary differential equations (ODEs) in the infinite population limit. Exploiting a boundary layer approximation to the ODEs and...
• Amino acid and protein specificity of protein fatty acylation in Caenorhabditis elegans AI翻译
  作者：Zhang, Bingsen; Yu, Yan; Fox, Bennett W.; Liu, Yinong; Thirumalaikumar, Venkatesh P.; Skirycz, Aleksandra; Lin, Hening; Schroedera, Frank C.
  作者单位：Cornell University; Boyce Thompson Institute for Plant Research; Cornell University; Howard Hughes Medical Institute; Cornell University; Cornell University
  摘要：Protein lipidation plays critical roles in regulating protein function and localization. However, the chemical diversity and specificity of fatty acyl group utilization have not been investigated using untargeted approaches, and it is unclear to what extent structures and biosynthetic origins of S-acyl moieties differ from N- and O - fatty acylation. Here, we show that fatty acylation patterns in Caenorhabditis elegans differ markedly between different amino acid residues. Hydroxylamine captur...
• Spectrally refined unbiased Monte Carlo estimate of the Earth's global radiative cooling AI翻译
  作者：Nyffenegger-Pere, Yaniss; Armante, Raymond; Bati, Megane; Blanco, Stephane; Dufresne, Jean-Louis; El Hafi, Mouna; Eymet, Vincent; Forest, Vincent; Fournier, Richard; Gautrais, Jacques; Lebrun, Raphael; Mellado, Nicolas; Mourtaday, Nada; Paulin, Mathias
  作者单位：Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Astrofisica de Andalucia (IAA); Universite PSL; Ecole Normale Superieure (ENS); Ecole Normale Superieure de Lyon (ENS de LYON); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Institut Polytechnique de Paris; Ecole Polytechnique; Universite de Toulouse; Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite Toulouse III - Paul Sabatier; Institut National Polytechnique de Toulouse; Universite Toulouse 1 Capitole; Universite de Toulouse - Jean Jaures; Centre National de la Recherche Scientifique (CNRS); IMT - Institut Mines-Telecom; Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite de Toulouse; IMT Mines Albi; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS)
  摘要：The Earth's radiative cooling is a key driver of climate. Determining how it is affected by greenhouse gas concentration is a core question in climate -change sciences. Due to the complexity of radiative transfer processes, current practices to estimate this cooling require the development and use of a suite of radiative transfer models whose accuracy diminishes as we move from local, instantaneous estimates to global estimates over the whole globe and over long periods of time (decades). Here...
• Structural phase purification of bulk HfO2:Y through pressure cycling AI翻译
  作者：Musfeldt, J. L.; Singh, Sobhit; Fan, Shiyu; Gu, Yanhong; Xu, Xianghan; Cheong, S. -W.; Liu, Z.; Vanderbilt, David; Rabe, Karin M.
  作者单位：University of Tennessee System; University of Tennessee Knoxville; University of Tennessee System; University of Tennessee Knoxville; University of Rochester; University of Rochester; United States Department of Energy (DOE); Brookhaven National Laboratory; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
  摘要：We combine synchrotron -based infrared absorption and Raman scattering spectroscopies with diamond anvil cell techniques and first -principles calculations to explore the properties of hafnia under compression. We find that pressure drives HfO2:7%Y from the mixed monoclinic (P21/c) + antipolar orthorhombic (Pbca) phase to pure antipolar orthorhombic (Pbca) phase at approximately 6.3 GPa. This transformation is irreversible, meaning that upon release, the material is kinetically trapped in the ...
• Viruses traverse the human proteome through peptide interfaces that can be biomimetically leveraged for drug discovery AI翻译
  作者：Schickin, Laurene Meyniel; Amaudrut, Jerome; Mallinjoud, Pierre; Guillier, Fabrice; Mangeot, Philippe E.; Lines, Laetitia; Aublin-Gex, Anne; Scholtes, Caroline; Punginelli, Claire; Joly, Stephane; Vasseur, Florence; Manet, Evelyne; Gruffat, Henri; Henry, Thomas; Halitim, Fares; Paparin, Jean-Laurent; Machin, Peter; Darteil, Raphael; Sampson, Diane; Mikaelian, Ivan; Lane, Lydie; Navratil, Vincent; Golinelli-Coher, Marie-Pierre; Terzi, Fabiola; Andre, Patrice; Lotteau, Vincent; Vonderscher, Jacky; Meldrum, Eric C.; de Chassey, Benoit
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); UNICANCER; Centre Leon Berard; Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Swiss Institute of Bioinformatics; Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS)
  摘要：We present a drug design strategy based on structural knowledge of protein-protein interfaces selected through virus-host coevolution and translated into highly potential small molecules. This approach is grounded on Vinland, the most comprehensive atlas of virus-human protein-protein interactions with annotation of interacting domains. From this inspiration, we identified small viral protein domains responsible for interaction with human proteins. These peptides form a library of new chemical...
• Manifold fitting with CycleGAN AI翻译
  作者：Yao, Zhigang; Su, Jiaji; Yau, Shing-Tung
  作者单位：National University of Singapore; Tsinghua University; Harvard University
  摘要：Manifold fitting, which offers substantial potential for efficient and accurate modeling, poses a critical challenge in nonlinear data analysis. This study presents an approach that employs neural networks to fit the latent manifold. Leveraging the generative adversarial framework, this method learns smooth mappings between low-dimensional latent space and high-dimensional ambient space, echoing the Riemannian exponential and logarithmic maps. The well-trained neural networks provide estimatio...
• Atomic observation and structural evolution of covalent organic framework rotamers AI翻译
  作者：Zeng, Tengwu; Ling, Yang; Jiang, Wentao; Yao, Xuan; Tao, Yu; Liu, Shan; Liu, Huiyu; Yang, Tieying; Wen, Wen; Jiang, Shan; Zhao, Yingbo; Ma, Yanhang; Zhang, Yue - Biao
  作者单位：ShanghaiTech University; ShanghaiTech University; Chinese Academy of Sciences; Shanghai Advanced Research Institute, CAS; ShanghaiTech University
  摘要：Dynamic 3D covalent organic frameworks (COFs) have shown concerted structural transformation and adaptive gas adsorption due to the conformational diversity of organic linkers. However, the isolation and observation of COF rotamers constitute undergoing challenges due to their comparable free energy and subtle rotational energy barrier. Here, we report the atomic-level observation and structural evolution of COF rotamers by cryo-3D electron diffraction and synchrotron powder X-ray diffraction....
• Nutrient- derived signals regulate eosinophil adaptation to the small intestine AI翻译
  作者：Kutyavin, Vassily I.; Korn, Lisa L.; Medzhitov, Ruslan
  作者单位：Yale University; Yale University; Howard Hughes Medical Institute; Yale University
  摘要：Eosinophils are well recognized as effector cells of type 2 immunity, yet they also accumuWe observed that eosinophils gradually migrate along the crypt-villus axis, giving rise to a villus- resident subpopulation with a distinct transcriptional signature. Retinoic acid signaling was specifically required for maintenance of this subpopulation, while IL- 5 was largely dispensable outside of its canonical role in eosinophil production. Surprisingly, we found that a high- protein diet suppressed ...