Nutrient- derived signals regulate eosinophil adaptation to the small intestine

• 成果类型: Article
• 署名作者: Kutyavin, Vassily I.; Korn, Lisa L.; Medzhitov, Ruslan
• 署名单位: Yale University; Yale University; Howard Hughes Medical Institute; Yale University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-14712
• DOI: 10.1073/pnas.2316446121
• 发表日期: 2024-01-30
• 关键词: innate lymphoid-cells; retinoic acid; gastrointestinal eosinophils; immune-response; amino-acids; macrophages; expression; tolerance; eotaxin; SYSTEM

摘要

Eosinophils are well recognized as effector cells of type 2 immunity, yet they also accumuWe observed that eosinophils gradually migrate along the crypt-villus axis, giving rise to a villus- resident subpopulation with a distinct transcriptional signature. Retinoic acid signaling was specifically required for maintenance of this subpopulation, while IL- 5 was largely dispensable outside of its canonical role in eosinophil production. Surprisingly, we found that a high- protein diet suppressed the accumulation of villus- resident eosinophils. Purified amino acids were sufficient for this effect, which was a consequence of accelerated eosinophil turnover within the tissue microenvironment and was not due to altered development in the bone marrow. Our study provides insight into the process of eosinophil adaptation to the SI, highlighting its reliance on nutrient- derived signals.