5期

最新文章

• miR-137 regulates PTP61F, affecting insulin signaling, metabolic homeostasis, and starvation resistance in Drosophila AI翻译
  作者：Saedi, Hana; Waro, Girma; Giacchetta, Lea; Tsunoda, Susan
  作者单位：Colorado State University System; Colorado State University Fort Collins
  摘要：miR-137is a highly conserved brain- enriched microRNA (miRNA) that has been associated with neuronal function and proliferation. Here, we show that Drosophila miR-137 null mutants display increased body weight with enhanced triglyceride content and decreased locomotor activity. In addition, when challenged by nutrient deprivation, miR-137 mutants exhibit reduced motivation to feed and prolonged survival. We show through genetic epistasis and rescue experiments that this starvation resistance i...
• Siglec-15/sialic acid axis as a central glyco- immune checkpoint in breast cancer bone metastasis AI翻译
  作者：Wang, Yixian; Xu, Zhan; Yu, Liqun; Wang, Chenhang; Ding, Haoxue; Gao, Yang; Sun, Han; Xia, Meng; Chen, Yuda; Wu, Kuan- Lin; Wu, Yi-Hsuan; Xiao, Han
  作者单位：Rice University; Baylor College of Medicine; Rice University; Rice University
  摘要：Immunotherapy is a promising approach for treating metastatic breast cancer (MBC), offering new possibilities for therapy. While checkpoint inhibitors have shown great progress in the treatment of metastatic breast cancer, their effectiveness in patients with bone metastases has been disappointing. This lack of efficacy seems to be specific to the bone environment, which exhibits immunosuppressive features. In this study, we elucidate the multiple roles of the sialic acid-binding Ig-like lecti...
• Synonymous edits in the Escherichia coli genome have substantial and condition- dependent effects on fitness AI翻译
  作者：Yang, Dong-Dong; Rusch, Leo M.; Widney, Karl A.; Morgenthaler, Andrew B.; Copley, Shelley D.
  作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder
  摘要：CRISPR-Cas-based genome editing is widely used in bacteria at scales ranging from construction of individual mutants to massively parallel libraries. This procedure relies on guide RNA- directed cleavage of the genome followed by repair with a template that introduces a desired mutation along with synonymous immunizing mutations to prevent re- cleavage of the genome after editing. Because the immunizing mutations do not change the protein sequence, they are often assumed to be neutral. However...
• A disinhibitory circuit mechanism explains a general principle of peak performance during mid- level arousal AI翻译
  作者：Beerendonk, Lola; Mejias, Jorge F.; Nuiten, Stijn A.; de Gee, Jan Willem; Fahrenfort, Johannes J.; van Gaal, Simon
  作者单位：University of Amsterdam; University of Amsterdam; University of Amsterdam; University of Basel; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
  摘要：Perceptual decision- making is highly dependent on the momentary arousal state of the brain, which fluctuates over time on a scale of hours, minutes, and even seconds. The textbook relationship between momentary arousal and task performance is captured by an inverted U- shape, as put forward in the Yerkes-Dodson law. This law suggests optimal performance at moderate levels of arousal and impaired performance at low or high arousal levels. However, despite its popularity, the evidence for this ...